Iron in PDB 5oqm: Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator

All present enzymatic activity of Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator:
2.7.7.6; 3.6.4.12;

The structure of Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	16 atoms

The binding sites of Iron atom in the Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator (pdb code 5oqm). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator, PDB code: 5oqm:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe901 b:0.0 occ:1.00 FE1 0:SF4901 0.0 0.0 1.0 SG 0:CYS115 2.2 0.0 1.0 S4 0:SF4901 2.3 0.0 1.0 S3 0:SF4901 2.3 0.0 1.0 S2 0:SF4901 2.3 0.0 1.0 FE3 0:SF4901 2.7 0.0 1.0 FE2 0:SF4901 2.7 0.0 1.0 FE4 0:SF4901 2.7 0.0 1.0 SG 0:CYS133 3.4 0.0 1.0 S1 0:SF4901 3.9 0.0 1.0 CB 0:CYS115 4.0 0.0 1.0 CB 0:HIS117 4.2 0.0 1.0 SG 0:CYS191 4.4 0.0 1.0 CD 0:PRO118 4.5 0.0 1.0 CB 0:CYS133 4.5 0.0 1.0 N 0:HIS117 4.7 0.0 1.0 SG 0:CYS156 4.7 0.0 1.0 CA 0:CYS133 4.8 0.0 1.0 CA 0:CYS115 4.9 0.0 1.0 N 0:LEU116 5.0 0.0 1.0

Iron binding site 2 out of 4 in the Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe901 b:0.0 occ:1.00 FE2 0:SF4901 0.0 0.0 1.0 SG 0:CYS156 2.2 0.0 1.0 S1 0:SF4901 2.3 0.0 1.0 S3 0:SF4901 2.3 0.0 1.0 S4 0:SF4901 2.3 0.0 1.0 FE4 0:SF4901 2.7 0.0 1.0 FE3 0:SF4901 2.7 0.0 1.0 FE1 0:SF4901 2.7 0.0 1.0 CB 0:CYS156 3.6 0.0 1.0 S2 0:SF4901 3.9 0.0 1.0 SG 0:CYS191 4.4 0.0 1.0 CB 0:MET136 4.4 0.0 1.0 CB 0:HIS117 4.5 0.0 1.0 SG 0:CYS133 4.5 0.0 1.0 SG 0:CYS115 4.8 0.0 1.0 N 0:GLU157 4.8 0.0 1.0 CA 0:CYS156 4.8 0.0 1.0

Iron binding site 3 out of 4 in the Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe901 b:0.0 occ:1.00 FE3 0:SF4901 0.0 0.0 1.0 SG 0:CYS133 2.0 0.0 1.0 S2 0:SF4901 2.3 0.0 1.0 S4 0:SF4901 2.3 0.0 1.0 S1 0:SF4901 2.3 0.0 1.0 FE4 0:SF4901 2.7 0.0 1.0 FE2 0:SF4901 2.7 0.0 1.0 FE1 0:SF4901 2.7 0.0 1.0 CB 0:CYS133 3.5 0.0 1.0 CA 0:CYS133 3.8 0.0 1.0 S3 0:SF4901 3.9 0.0 1.0 CE2 0:PHE194 4.2 0.0 1.0 O 0:CYS133 4.3 0.0 1.0 SG 0:CYS191 4.3 0.0 1.0 SG 0:CYS115 4.5 0.0 1.0 C 0:CYS133 4.5 0.0 1.0 SG 0:CYS156 4.6 0.0 1.0 CB 0:MET136 4.6 0.0 1.0 CD2 0:TYR193 4.8 0.0 1.0 CZ 0:PHE194 4.9 0.0 1.0

Iron binding site 4 out of 4 in the Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Structure of Yeast Transcription Pre-Initiation Complex with Tfiih and Core Mediator within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe901 b:0.0 occ:1.00 FE4 0:SF4901 0.0 0.0 1.0 SG 0:CYS191 1.9 0.0 1.0 S1 0:SF4901 2.3 0.0 1.0 S3 0:SF4901 2.3 0.0 1.0 S2 0:SF4901 2.3 0.0 1.0 FE2 0:SF4901 2.7 0.0 1.0 FE3 0:SF4901 2.7 0.0 1.0 FE1 0:SF4901 2.7 0.0 1.0 CB 0:CYS191 3.2 0.0 1.0 SG 0:CYS115 3.9 0.0 1.0 S4 0:SF4901 3.9 0.0 1.0 SG 0:CYS133 4.1 0.0 1.0 CA 0:CYS191 4.4 0.0 1.0 SG 0:CYS156 4.6 0.0 1.0 CB 0:TYR193 4.6 0.0 1.0 CE2 0:PHE194 4.7 0.0 1.0 CD2 0:PHE194 4.8 0.0 1.0

S.Schilbach, M.Hantsche, D.Tegunov, C.Dienemann, C.Wigge, H.Urlaub, P.Cramer. Structures of Transcription Pre-Initiation Complex with Tfiih and Mediator. Nature V. 551 204 2017.
ISSN: ESSN 1476-4687
PubMed: 29088706
DOI: 10.1038/NATURE24282