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Atomistry » Iron » PDB 5tia-5ufg » 5tz1 » |
Iron in PDB 5tz1: Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1)Enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1)
All present enzymatic activity of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1):
1.14.13.70; Protein crystallography data
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1), PDB code: 5tz1
was solved by
T.Hargrove,
Z.Wawrzak,
G.Lepesheva,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5tz1:
The structure of Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1) also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1)
(pdb code 5tz1). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1), PDB code: 5tz1: Jump to Iron binding site number: 1; 2; Iron binding site 1 out of 2 in 5tz1Go back to![]() ![]()
Iron binding site 1 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1)
![]() Mono view ![]() Stereo pair view
Iron binding site 2 out of 2 in 5tz1Go back to![]() ![]()
Iron binding site 2 out
of 2 in the Crystal Structure of Sterol 14-Alpha Demethylase (CYP51) From Candida Albicans in Complex with the Tetrazole-Based Antifungal Drug Candidate VT1161 (VT1)
![]() Mono view ![]() Stereo pair view
Reference:
T.Y.Hargrove,
L.Friggeri,
Z.Wawrzak,
A.Qi,
W.J.Hoekstra,
R.J.Schotzinger,
J.D.York,
F.P.Guengerich,
G.I.Lepesheva.
Structural Analyses of Candida Albicans Sterol 14 Alpha-Demethylase Complexed with Azole Drugs Address the Molecular Basis of Azole-Mediated Inhibition of Fungal Sterol Biosynthesis. J. Biol. Chem. V. 292 6728 2017.
Page generated: Sun Dec 13 16:12:54 2020
ISSN: ESSN 1083-351X PubMed: 28258218 DOI: 10.1074/JBC.M117.778308 |
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