Iron in PDB 6alq: Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate

All present enzymatic activity of Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate:
1.14.11.41;

The structure of Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate, PDB code: 6alq was solved by N.P.Dunham, A.J.Mitchell, A.K.Boal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.10 / 1.67
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	80.844, 66.751, 62.922, 90.00, 109.27, 90.00
R / Rfree (%)	18.1 / 20

The binding sites of Iron atom in the Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate (pdb code 6alq). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate, PDB code: 6alq:

Iron binding site 1 out of 1 in the Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Vioc L-Arginine Hydroxylase Bound to Fe(II), L-Arginine, and Succinate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe401 b:15.8 occ:1.00 OE1 A:GLU170 2.1 15.4 1.0 O4 A:SIN402 2.2 20.1 1.0 NE2 A:HIS316 2.2 15.1 1.0 NE2 A:HIS168 2.3 15.3 1.0 O3 A:SIN402 2.3 21.9 1.0 C4 A:SIN402 2.6 20.1 1.0 CE1 A:HIS316 3.1 15.0 1.0 CD A:GLU170 3.1 15.6 1.0 CE1 A:HIS168 3.1 15.1 1.0 CD2 A:HIS316 3.2 14.8 1.0 CD2 A:HIS168 3.3 15.0 1.0 OE2 A:GLU170 3.4 16.3 1.0 C3 A:SIN402 4.1 19.6 1.0 N A:ARG403 4.1 25.1 1.0 ND1 A:HIS316 4.1 14.8 1.0 CG A:HIS316 4.2 14.4 1.0 ND1 A:HIS168 4.3 14.8 1.0 CG A:HIS168 4.4 14.6 1.0 CG A:GLU170 4.4 15.2 1.0 NH1 A:ARG334 4.5 20.7 1.0 CB A:ARG403 4.7 24.5 1.0 CB A:GLU170 4.7 14.8 1.0 CG A:ARG403 4.8 24.2 1.0 C2 A:SIN402 4.8 18.9 1.0 CD2 A:LEU165 4.9 16.1 1.0 CA A:ARG403 5.0 24.8 1.0 CA A:GLU170 5.0 14.6 1.0 O A:HIS316 5.0 13.2 1.0

A.J.Mitchell, N.P.Dunham, R.J.Martinie, J.A.Bergman, C.J.Pollock, K.Hu, B.D.Allen, W.C.Chang, A.Silakov, J.M.Bollinger, C.Krebs, A.K.Boal. Visualizing the Reaction Cycle in An Iron(II)- and 2-(Oxo)-Glutarate-Dependent Hydroxylase. J. Am. Chem. Soc. V. 139 13830 2017.
ISSN: ESSN 1520-5126
PubMed: 28823155
DOI: 10.1021/JACS.7B07374