Iron in PDB 6hcy: Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta.

The binding sites of Iron atom in the Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta. (pdb code 6hcy). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 3 binding sites of Iron where determined in the Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta., PDB code: 6hcy:
Jump to Iron binding site number: 1; 2; 3;

Iron binding site 1 out of 3 in the Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta. within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe502 b:64.6 occ:1.00 FE C:HEM502 0.0 64.6 1.0 ND C:HEM502 1.9 64.6 1.0 NA C:HEM502 2.0 64.6 1.0 NE2 C:HIS397 2.0 64.0 1.0 NE2 C:HIS304 2.0 59.2 1.0 NC C:HEM502 2.1 64.6 1.0 NB C:HEM502 2.1 64.6 1.0 C4D C:HEM502 2.8 64.6 1.0 CD2 C:HIS397 2.9 64.0 1.0 C1D C:HEM502 2.9 64.6 1.0 C1A C:HEM502 2.9 64.6 1.0 CD2 C:HIS304 3.0 59.2 1.0 C4A C:HEM502 3.0 64.6 1.0 C4C C:HEM502 3.0 64.6 1.0 CE1 C:HIS304 3.0 59.2 1.0 C1B C:HEM502 3.1 64.6 1.0 C4B C:HEM502 3.1 64.6 1.0 CE1 C:HIS397 3.1 64.0 1.0 C1C C:HEM502 3.1 64.6 1.0 CHA C:HEM502 3.3 64.6 1.0 CHD C:HEM502 3.4 64.6 1.0 CHB C:HEM502 3.5 64.6 1.0 CHC C:HEM502 3.5 64.6 1.0 CG C:HIS397 4.1 64.0 1.0 C3D C:HEM502 4.1 64.6 1.0 C2D C:HEM502 4.1 64.6 1.0 CG C:HIS304 4.1 59.2 1.0 C2A C:HEM502 4.1 64.6 1.0 ND1 C:HIS304 4.1 59.2 1.0 ND1 C:HIS397 4.1 64.0 1.0 C3A C:HEM502 4.2 64.6 1.0 C3C C:HEM502 4.2 64.6 1.0 C2C C:HEM502 4.3 64.6 1.0 C2B C:HEM502 4.3 64.6 1.0 C3B C:HEM502 4.3 64.6 1.0 CB C:PRO248 4.9 62.7 1.0

Iron binding site 2 out of 3 in the Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta. within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe502 b:64.3 occ:1.00 FE A:HEM502 0.0 64.3 1.0 ND A:HEM502 1.9 64.3 1.0 NA A:HEM502 2.0 64.3 1.0 NE2 A:HIS397 2.0 63.3 1.0 NE2 A:HIS304 2.0 59.4 1.0 NC A:HEM502 2.1 64.3 1.0 NB A:HEM502 2.1 64.3 1.0 C4D A:HEM502 2.8 64.3 1.0 CD2 A:HIS397 2.9 63.3 1.0 C1D A:HEM502 2.9 64.3 1.0 C1A A:HEM502 2.9 64.3 1.0 CD2 A:HIS304 3.0 59.4 1.0 C4A A:HEM502 3.0 64.3 1.0 C4C A:HEM502 3.0 64.3 1.0 CE1 A:HIS304 3.0 59.4 1.0 C1B A:HEM502 3.1 64.3 1.0 C4B A:HEM502 3.1 64.3 1.0 CE1 A:HIS397 3.1 63.3 1.0 C1C A:HEM502 3.1 64.3 1.0 CHA A:HEM502 3.3 64.3 1.0 CHD A:HEM502 3.4 64.3 1.0 CHB A:HEM502 3.5 64.3 1.0 CHC A:HEM502 3.5 64.3 1.0 CG A:HIS397 4.1 63.3 1.0 C3D A:HEM502 4.1 64.3 1.0 C2D A:HEM502 4.1 64.3 1.0 CG A:HIS304 4.1 59.4 1.0 C2A A:HEM502 4.1 64.3 1.0 ND1 A:HIS304 4.1 59.4 1.0 ND1 A:HIS397 4.1 63.3 1.0 C3A A:HEM502 4.2 64.3 1.0 C3C A:HEM502 4.2 64.3 1.0 C2C A:HEM502 4.3 64.3 1.0 C2B A:HEM502 4.3 64.3 1.0 C3B A:HEM502 4.3 64.3 1.0 CB A:PRO248 4.9 62.3 1.0

Iron binding site 3 out of 3 in the Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human STEAP4 Bound to Nadp, Fad, Heme and Fe(III)-Nta. within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe502 b:63.7 occ:1.00 FE B:HEM502 0.0 63.7 1.0 ND B:HEM502 1.9 63.7 1.0 NA B:HEM502 2.0 63.7 1.0 NE2 B:HIS397 2.0 63.0 1.0 NE2 B:HIS304 2.0 59.0 1.0 NC B:HEM502 2.1 63.7 1.0 NB B:HEM502 2.1 63.7 1.0 C4D B:HEM502 2.8 63.7 1.0 CD2 B:HIS397 2.9 63.0 1.0 C1D B:HEM502 2.9 63.7 1.0 C1A B:HEM502 2.9 63.7 1.0 CD2 B:HIS304 3.0 59.0 1.0 C4A B:HEM502 3.0 63.7 1.0 C4C B:HEM502 3.0 63.7 1.0 CE1 B:HIS304 3.0 59.0 1.0 C1B B:HEM502 3.1 63.7 1.0 C4B B:HEM502 3.1 63.7 1.0 CE1 B:HIS397 3.1 63.0 1.0 C1C B:HEM502 3.1 63.7 1.0 CHA B:HEM502 3.3 63.7 1.0 CHD B:HEM502 3.4 63.7 1.0 CHB B:HEM502 3.5 63.7 1.0 CHC B:HEM502 3.5 63.7 1.0 CG B:HIS397 4.1 63.0 1.0 C3D B:HEM502 4.1 63.7 1.0 C2D B:HEM502 4.1 63.7 1.0 CG B:HIS304 4.1 59.0 1.0 C2A B:HEM502 4.1 63.7 1.0 ND1 B:HIS304 4.1 59.0 1.0 ND1 B:HIS397 4.1 63.0 1.0 C3A B:HEM502 4.2 63.7 1.0 C3C B:HEM502 4.2 63.7 1.0 C2C B:HEM502 4.3 63.7 1.0 C2B B:HEM502 4.3 63.7 1.0 C3B B:HEM502 4.3 63.7 1.0 CB B:PRO248 4.9 61.6 1.0

W.Oosterheert, L.S.Van Bezouwen, R.N.P.Rodenburg, J.Granneman, F.Forster, A.Mattevi, P.Gros. Cryo-Em Structures of Human STEAP4 Reveal Mechanism of Iron(III) Reduction. Nat Commun V. 9 4337 2018.
ISSN: ESSN 2041-1723
PubMed: 30337524
DOI: 10.1038/S41467-018-06817-7