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Iron in PDB 6i8a: The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.

Enzymatic activity of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.

All present enzymatic activity of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.:
2.7.7.7;

Protein crystallography data

The structure of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution., PDB code: 6i8a was solved by V.Parkash, E.Johansson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.96 / 2.65
Space group P 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 154.466, 70.257, 159.335, 90.00, 112.85, 90.00
R / Rfree (%) 22.9 / 27.9

Other elements in 6i8a:

The structure of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Iron Binding Sites:

The binding sites of Iron atom in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. (pdb code 6i8a). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution., PDB code: 6i8a:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 6i8a

Go back to Iron Binding Sites List in 6i8a
Iron binding site 1 out of 2 in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1304

b:0.3
occ:0.80
 SG A:CYS763 2.3 71.7 1.0
SG A:CYS677 2.3 92.7 1.0
O A:CYS677 3.3 85.4 1.0
CB A:CYS763 3.5 73.7 1.0
CB A:CYS677 3.8 82.3 1.0
C A:CYS677 4.3 87.5 1.0
CA A:CYS763 4.3 69.9 1.0
CA A:CYS677 4.6 85.2 1.0

Iron binding site 2 out of 2 in 6i8a

Go back to Iron Binding Sites List in 6i8a
Iron binding site 2 out of 2 in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe1304

b:97.6
occ:0.80
 SG B:CYS677 2.3 94.7 1.0
SG B:CYS763 2.3 78.1 1.0
CB B:CYS763 3.4 73.3 1.0
O B:CYS677 3.6 90.2 1.0
CA B:CYS763 4.0 70.8 1.0
CB B:CYS677 4.0 93.7 1.0
C B:CYS677 4.3 92.6 1.0
CA B:CYS677 4.8 92.5 1.0
C B:CYS763 5.0 72.1 1.0
N B:CYS763 5.0 70.5 1.0

Reference:

V.Parkash, Y.Kulkarni, J.Ter Beek, P.V.Shcherbakova, S.C.L.Kamerlin, E.Johansson. Structural Consequence of the Most Frequently Recurring Cancer-Associated Substitution in Dna Polymerase Epsilon. Nat Commun V. 10 373 2019.
ISSN: ESSN 2041-1723
PubMed: 30670696
DOI: 10.1038/S41467-018-08114-9
Page generated: Sun Dec 13 16:29:52 2020

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