Iron in PDB 6s1n: Human Polymerase Delta Holoenzyme Conformer 2
Enzymatic activity of Human Polymerase Delta Holoenzyme Conformer 2
All present enzymatic activity of Human Polymerase Delta Holoenzyme Conformer 2:
2.7.7.7;
Other elements in 6s1n:
The structure of Human Polymerase Delta Holoenzyme Conformer 2 also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Human Polymerase Delta Holoenzyme Conformer 2
(pdb code 6s1n). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the
Human Polymerase Delta Holoenzyme Conformer 2, PDB code: 6s1n:
Jump to Iron binding site number:
1;
2;
3;
4;
Iron binding site 1 out
of 4 in 6s1n
Go back to
Iron Binding Sites List in 6s1n
Iron binding site 1 out
of 4 in the Human Polymerase Delta Holoenzyme Conformer 2
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Human Polymerase Delta Holoenzyme Conformer 2 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1202
b:40.6
occ:1.00
|
FE1
|
A:SF41202
|
0.0
|
40.6
|
1.0
|
SG
|
A:CYS1071
|
2.3
|
40.6
|
1.0
|
S3
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S2
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S4
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
FE4
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE3
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE2
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
CB
|
A:CYS1071
|
3.3
|
40.6
|
1.0
|
O
|
A:CYS1071
|
3.9
|
40.6
|
1.0
|
S1
|
A:SF41202
|
3.9
|
40.6
|
1.0
|
CG2
|
A:ILE1078
|
4.0
|
40.6
|
1.0
|
C
|
A:CYS1071
|
4.4
|
40.6
|
1.0
|
SG
|
A:CYS1076
|
4.4
|
30.9
|
1.0
|
CA
|
A:CYS1071
|
4.4
|
40.6
|
1.0
|
CB
|
A:SER1073
|
4.5
|
35.8
|
1.0
|
CB
|
A:CYS1076
|
4.6
|
30.9
|
1.0
|
SG
|
A:CYS1058
|
4.6
|
40.6
|
1.0
|
SG
|
A:CYS1061
|
4.8
|
24.8
|
1.0
|
NH1
|
A:ARG1082
|
4.9
|
40.6
|
1.0
|
CB
|
A:ILE1078
|
4.9
|
40.6
|
1.0
|
N
|
A:SER1073
|
4.9
|
35.8
|
1.0
|
|
Iron binding site 2 out
of 4 in 6s1n
Go back to
Iron Binding Sites List in 6s1n
Iron binding site 2 out
of 4 in the Human Polymerase Delta Holoenzyme Conformer 2
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Human Polymerase Delta Holoenzyme Conformer 2 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1202
b:40.6
occ:1.00
|
FE2
|
A:SF41202
|
0.0
|
40.6
|
1.0
|
CG2
|
A:ILE1078
|
2.3
|
40.6
|
1.0
|
SG
|
A:CYS1076
|
2.3
|
30.9
|
1.0
|
S4
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S1
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S3
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
CB
|
A:ILE1078
|
2.4
|
40.6
|
1.0
|
FE3
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE1
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE4
|
A:SF41202
|
2.8
|
40.6
|
1.0
|
CG1
|
A:ILE1078
|
3.3
|
40.6
|
1.0
|
CB
|
A:CYS1076
|
3.3
|
30.9
|
1.0
|
CA
|
A:ILE1078
|
3.6
|
40.6
|
1.0
|
N
|
A:PHE1079
|
3.9
|
40.6
|
1.0
|
S2
|
A:SF41202
|
3.9
|
40.6
|
1.0
|
N
|
A:ILE1078
|
4.0
|
40.6
|
1.0
|
C
|
A:ILE1078
|
4.0
|
40.6
|
1.0
|
CD1
|
A:ILE1078
|
4.6
|
40.6
|
1.0
|
CA
|
A:CYS1076
|
4.7
|
30.9
|
1.0
|
SG
|
A:CYS1058
|
4.8
|
40.6
|
1.0
|
SG
|
A:CYS1071
|
4.9
|
40.6
|
1.0
|
C
|
A:CYS1076
|
4.9
|
30.9
|
1.0
|
CA
|
A:PHE1079
|
5.0
|
40.6
|
1.0
|
|
Iron binding site 3 out
of 4 in 6s1n
Go back to
Iron Binding Sites List in 6s1n
Iron binding site 3 out
of 4 in the Human Polymerase Delta Holoenzyme Conformer 2
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Human Polymerase Delta Holoenzyme Conformer 2 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1202
b:40.6
occ:1.00
|
FE3
|
A:SF41202
|
0.0
|
40.6
|
1.0
|
S1
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
SG
|
A:CYS1058
|
2.3
|
40.6
|
1.0
|
S4
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S2
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
CG2
|
A:ILE1078
|
2.3
|
40.6
|
1.0
|
FE2
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE4
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE1
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
CB
|
A:CYS1058
|
3.5
|
40.6
|
1.0
|
CA
|
A:CYS1058
|
3.7
|
40.6
|
1.0
|
CB
|
A:ILE1078
|
3.7
|
40.6
|
1.0
|
S3
|
A:SF41202
|
3.8
|
40.6
|
1.0
|
N
|
A:CYS1058
|
4.4
|
40.6
|
1.0
|
CG1
|
A:ILE1078
|
4.5
|
40.6
|
1.0
|
NE
|
A:ARG1082
|
4.5
|
40.6
|
1.0
|
SG
|
A:CYS1061
|
4.8
|
24.8
|
1.0
|
SG
|
A:CYS1071
|
4.8
|
40.6
|
1.0
|
C
|
A:CYS1058
|
4.9
|
40.6
|
1.0
|
SG
|
A:CYS1076
|
4.9
|
30.9
|
1.0
|
NH1
|
A:ARG1082
|
5.0
|
40.6
|
1.0
|
CB
|
A:CYS1061
|
5.0
|
24.8
|
1.0
|
CA
|
A:ILE1078
|
5.0
|
40.6
|
1.0
|
|
Iron binding site 4 out
of 4 in 6s1n
Go back to
Iron Binding Sites List in 6s1n
Iron binding site 4 out
of 4 in the Human Polymerase Delta Holoenzyme Conformer 2
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Human Polymerase Delta Holoenzyme Conformer 2 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1202
b:40.6
occ:1.00
|
FE4
|
A:SF41202
|
0.0
|
40.6
|
1.0
|
S2
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S3
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
S1
|
A:SF41202
|
2.3
|
40.6
|
1.0
|
SG
|
A:CYS1061
|
2.4
|
24.8
|
1.0
|
FE1
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE3
|
A:SF41202
|
2.7
|
40.6
|
1.0
|
FE2
|
A:SF41202
|
2.8
|
40.6
|
1.0
|
CB
|
A:CYS1061
|
3.4
|
24.8
|
1.0
|
S4
|
A:SF41202
|
3.9
|
40.6
|
1.0
|
SG
|
A:CYS1076
|
4.1
|
30.9
|
1.0
|
CG2
|
A:ILE1078
|
4.1
|
40.6
|
1.0
|
SG
|
A:CYS1071
|
4.4
|
40.6
|
1.0
|
CB
|
A:ILE1078
|
4.7
|
40.6
|
1.0
|
CA
|
A:CYS1061
|
4.8
|
24.8
|
1.0
|
SG
|
A:CYS1058
|
4.8
|
40.6
|
1.0
|
CA
|
A:CYS1058
|
5.0
|
40.6
|
1.0
|
|
Reference:
C.Lancey,
M.Tehseen,
V.S.Raducanu,
F.Rashid,
N.Merino,
T.J.Ragan,
C.Savva,
M.S.Zaher,
A.Shirbini,
F.J.Blanco,
S.M.Hamdan,
A.De Biasio.
Structure of the Processive Human Pol Delta Holoenzyme To Be Published.
Page generated: Wed Aug 7 09:26:42 2024
|