Iron in PDB 6s2f: Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
Enzymatic activity of Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
All present enzymatic activity of Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2):
2.7.7.7;
Iron Binding Sites:
The binding sites of Iron atom in the Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
(pdb code 6s2f). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the
Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2), PDB code: 6s2f:
Jump to Iron binding site number:
1;
2;
3;
4;
Iron binding site 1 out
of 4 in 6s2f
Go back to
Iron Binding Sites List in 6s2f
Iron binding site 1 out
of 4 in the Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1401
b:0.6
occ:1.00
|
FE1
|
A:SF41401
|
0.0
|
0.6
|
1.0
|
S4
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
SG
|
A:CYS677
|
2.1
|
0.1
|
1.0
|
S2
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S3
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
FE2
|
A:SF41401
|
2.4
|
0.6
|
1.0
|
FE3
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
FE4
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
CB
|
A:CYS677
|
2.9
|
0.1
|
1.0
|
S1
|
A:SF41401
|
3.6
|
0.6
|
1.0
|
NH1
|
A:ARG765
|
3.7
|
0.3
|
1.0
|
CB
|
A:CYS763
|
3.8
|
0.1
|
1.0
|
CA
|
A:CYS677
|
4.1
|
0.1
|
1.0
|
C
|
A:CYS677
|
4.1
|
0.1
|
1.0
|
CD
|
A:ARG765
|
4.1
|
0.3
|
1.0
|
SG
|
A:CYS665
|
4.2
|
0.4
|
1.0
|
SG
|
A:CYS763
|
4.2
|
0.1
|
1.0
|
O
|
A:CYS677
|
4.3
|
0.1
|
1.0
|
CA
|
A:CYS763
|
4.4
|
0.1
|
1.0
|
N
|
A:ALA678
|
4.6
|
0.6
|
1.0
|
SG
|
A:CYS668
|
4.6
|
0.8
|
1.0
|
O
|
A:ASP669
|
4.7
|
0.1
|
1.0
|
CZ
|
A:ARG765
|
4.7
|
0.3
|
1.0
|
CB
|
A:ARG765
|
4.7
|
0.3
|
1.0
|
N
|
A:GLN764
|
4.8
|
0.4
|
1.0
|
CG
|
A:ARG765
|
4.8
|
0.3
|
1.0
|
NE
|
A:ARG765
|
4.9
|
0.3
|
1.0
|
N
|
A:ARG765
|
5.0
|
0.3
|
1.0
|
C
|
A:CYS763
|
5.0
|
0.1
|
1.0
|
|
Iron binding site 2 out
of 4 in 6s2f
Go back to
Iron Binding Sites List in 6s2f
Iron binding site 2 out
of 4 in the Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1401
b:0.6
occ:1.00
|
FE2
|
A:SF41401
|
0.0
|
0.6
|
1.0
|
S3
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S1
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S4
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
SG
|
A:CYS668
|
2.2
|
0.8
|
1.0
|
FE1
|
A:SF41401
|
2.4
|
0.6
|
1.0
|
FE4
|
A:SF41401
|
2.4
|
0.6
|
1.0
|
FE3
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
NH1
|
A:ARG765
|
3.1
|
0.3
|
1.0
|
CB
|
A:CYS668
|
3.4
|
0.8
|
1.0
|
S2
|
A:SF41401
|
3.6
|
0.6
|
1.0
|
CD2
|
A:LEU181
|
3.8
|
0.6
|
1.0
|
CZ
|
A:ARG765
|
4.1
|
0.3
|
1.0
|
O
|
A:CYS668
|
4.1
|
0.8
|
1.0
|
C
|
A:CYS668
|
4.3
|
0.8
|
1.0
|
N
|
A:CYS665
|
4.3
|
0.4
|
1.0
|
SG
|
A:CYS677
|
4.3
|
0.1
|
1.0
|
CA
|
A:CYS668
|
4.3
|
0.8
|
1.0
|
CA
|
A:CYS665
|
4.4
|
0.4
|
1.0
|
SG
|
A:CYS665
|
4.6
|
0.4
|
1.0
|
SG
|
A:CYS763
|
4.7
|
0.1
|
1.0
|
CB
|
A:CYS763
|
4.7
|
0.1
|
1.0
|
CD
|
A:ARG765
|
4.7
|
0.3
|
1.0
|
NE
|
A:ARG765
|
4.8
|
0.3
|
1.0
|
NH2
|
A:ARG765
|
4.8
|
0.3
|
1.0
|
N
|
A:CYS668
|
4.8
|
0.8
|
1.0
|
O
|
A:ASP669
|
4.9
|
0.1
|
1.0
|
CB
|
A:CYS677
|
4.9
|
0.1
|
1.0
|
N
|
A:ASP669
|
5.0
|
0.1
|
1.0
|
|
Iron binding site 3 out
of 4 in 6s2f
Go back to
Iron Binding Sites List in 6s2f
Iron binding site 3 out
of 4 in the Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1401
b:0.6
occ:1.00
|
FE3
|
A:SF41401
|
0.0
|
0.6
|
1.0
|
S2
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S4
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S1
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
SG
|
A:CYS763
|
2.2
|
0.1
|
1.0
|
FE4
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
FE1
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
FE2
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
CB
|
A:CYS763
|
2.6
|
0.1
|
1.0
|
S3
|
A:SF41401
|
3.6
|
0.6
|
1.0
|
CA
|
A:CYS763
|
3.8
|
0.1
|
1.0
|
CB
|
A:ASP664
|
3.8
|
0.4
|
1.0
|
N
|
A:CYS665
|
4.3
|
0.4
|
1.0
|
SG
|
A:CYS668
|
4.4
|
0.8
|
1.0
|
SG
|
A:CYS665
|
4.4
|
0.4
|
1.0
|
OD2
|
A:ASP664
|
4.5
|
0.4
|
1.0
|
SG
|
A:CYS677
|
4.5
|
0.1
|
1.0
|
CG
|
A:ASP664
|
4.6
|
0.4
|
1.0
|
CA
|
A:ASP664
|
4.7
|
0.4
|
1.0
|
N
|
A:CYS763
|
4.7
|
0.1
|
1.0
|
C
|
A:CYS763
|
4.8
|
0.1
|
1.0
|
CG
|
A:GLU766
|
4.9
|
0.1
|
1.0
|
CD
|
A:GLU766
|
5.0
|
0.1
|
1.0
|
|
Iron binding site 4 out
of 4 in 6s2f
Go back to
Iron Binding Sites List in 6s2f
Iron binding site 4 out
of 4 in the Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2)
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Cryo-Em Structure of CTF18-1-8 in Complex with the Catalytic Domain of Dna Polymerase Epsilon (Class 2) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe1401
b:0.6
occ:1.00
|
FE4
|
A:SF41401
|
0.0
|
0.6
|
1.0
|
S2
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S3
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
S1
|
A:SF41401
|
2.1
|
0.6
|
1.0
|
SG
|
A:CYS665
|
2.2
|
0.4
|
1.0
|
FE2
|
A:SF41401
|
2.4
|
0.6
|
1.0
|
FE3
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
FE1
|
A:SF41401
|
2.5
|
0.6
|
1.0
|
N
|
A:CYS665
|
2.8
|
0.4
|
1.0
|
CA
|
A:CYS665
|
3.0
|
0.4
|
1.0
|
CB
|
A:CYS665
|
3.1
|
0.4
|
1.0
|
S4
|
A:SF41401
|
3.6
|
0.6
|
1.0
|
CB
|
A:ASP664
|
3.8
|
0.4
|
1.0
|
C
|
A:ASP664
|
3.8
|
0.4
|
1.0
|
SG
|
A:CYS668
|
4.0
|
0.8
|
1.0
|
CB
|
A:CYS677
|
4.0
|
0.1
|
1.0
|
O
|
A:CYS668
|
4.2
|
0.8
|
1.0
|
SG
|
A:CYS763
|
4.2
|
0.1
|
1.0
|
SG
|
A:CYS677
|
4.2
|
0.1
|
1.0
|
CA
|
A:ASP664
|
4.2
|
0.4
|
1.0
|
CG
|
A:ASP664
|
4.4
|
0.4
|
1.0
|
C
|
A:CYS665
|
4.5
|
0.4
|
1.0
|
OD2
|
A:ASP664
|
4.6
|
0.4
|
1.0
|
O
|
A:ASP664
|
4.7
|
0.4
|
1.0
|
CB
|
A:CYS763
|
4.8
|
0.1
|
1.0
|
NH1
|
A:ARG765
|
4.8
|
0.3
|
1.0
|
C
|
A:CYS668
|
5.0
|
0.8
|
1.0
|
CB
|
A:PHE670
|
5.0
|
1.0
|
1.0
|
|
Reference:
K.Stokes,
A.Winczura,
B.Song,
G.De Piccoli,
D.B.Grabarczyk.
The Leading Strand Clamp Loader CTF18-Rfc Assumes Distinct Roles in Cohesion Establishment and Dna Replication To Be Published.
Page generated: Wed Aug 7 09:29:19 2024
|