Iron in PDB 6vcd: Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex

The binding sites of Iron atom in the Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex (pdb code 6vcd). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex, PDB code: 6vcd:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe800 b:23.9 occ:1.00 FE1 B:FES800 0.0 23.9 1.0 S1 B:FES800 2.2 23.9 1.0 S2 B:FES800 2.2 23.9 1.0 SG B:CYS662 2.8 26.2 1.0 SG B:CYS687 3.0 16.0 1.0 FE2 B:FES800 3.1 23.9 1.0 CB B:CYS662 3.3 26.2 1.0 CB B:CYS687 3.4 16.0 1.0 CA B:CYS662 3.7 26.2 1.0 N B:CYS687 3.8 16.0 1.0 CB B:LEU637 3.9 19.8 1.0 N B:ASP663 4.1 21.4 1.0 CA B:CYS687 4.2 16.0 1.0 CA B:LEU637 4.4 19.8 1.0 C B:CYS662 4.4 26.2 1.0 N B:ASN664 4.9 20.7 1.0 N B:CYS662 4.9 26.2 1.0 C B:CYS686 5.0 16.9 1.0 CB B:CYS676 5.0 24.3 1.0

Iron binding site 2 out of 2 in the Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of IRP2-FBXL5-SKP1 Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe800 b:23.9 occ:1.00 FE2 B:FES800 0.0 23.9 1.0 S2 B:FES800 2.2 23.9 1.0 S1 B:FES800 2.2 23.9 1.0 SG B:CYS686 2.9 16.9 1.0 SG B:CYS676 2.9 24.3 1.0 CB B:CYS676 3.1 24.3 1.0 FE1 B:FES800 3.1 23.9 1.0 CD2 B:LEU679 3.8 14.6 1.0 N B:CYS687 4.2 16.0 1.0 CB B:CYS686 4.3 16.9 1.0 CG B:ARG688 4.3 16.2 1.0 SG B:CYS687 4.4 16.0 1.0 CA B:CYS686 4.5 16.9 1.0 N B:ASP663 4.6 21.4 1.0 CG B:LEU679 4.6 14.6 1.0 CA B:CYS676 4.6 24.3 1.0 N B:ARG688 4.7 16.2 1.0 C B:CYS686 4.8 16.9 1.0 NE B:ARG688 4.8 16.2 1.0 CA B:CYS662 4.9 26.2 1.0 CD B:ARG688 5.0 16.2 1.0

H.Wang, H.Shi, M.Rajan, E.R.Canarie, S.Hong, D.Simoneschi, M.Pagano, M.F.Bush, S.Stoll, E.A.Leibold, N.Zheng. FBXL5 Regulates IRP2 Stability in Iron Homeostasis Via An Oxygen-Responsive [2FE2S] Cluster. Mol.Cell V. 78 31 2020.
ISSN: ISSN 1097-2765
PubMed: 32126207
DOI: 10.1016/J.MOLCEL.2020.02.011