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Iron in PDB 6vlt: Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Enzymatic activity of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
All present enzymatic activity of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan:
1.14.14.1; 1.14.14.51; 1.14.14.52; 1.14.14.53;
1.14.14.1; 1.14.14.51; 1.14.14.52; 1.14.14.53;
Protein crystallography data
The structure of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan, PDB code: 6vlt
was solved by
M.B.Shah,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.01 / 3.12 |
| Space group | P 31 |
| Cell size a, b, c (Å), α, β, γ (°) | 238.100, 238.100, 109.851, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 15.6 / 22.1 |
Other elements in 6vlt:
The structure of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan also contains other interesting chemical elements:
| Chlorine | (Cl) | 8 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
(pdb code 6vlt). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan, PDB code: 6vlt:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Iron where determined in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan, PDB code: 6vlt:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Iron binding site 1 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 1 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 2 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 2 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 3 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 3 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 4 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 4 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 5 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 5 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 6 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 6 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 7 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 7 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 7 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Iron binding site 8 out of 8 in 6vlt
Go back to
Iron Binding Sites List in 6vlt
Iron binding site 8 out
of 8 in the Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 8 of Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan within 5.0Å range:
|
Reference:
S.J.Parikh,
C.M.Evans,
J.O.Obi,
Q.Zhang,
K.Maekawa,
K.C.Glass,
M.B.Shah.
Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights Into the Effect of Genetic Polymorphism. Mol.Pharmacol. V. 98 529 2020.
ISSN: ESSN 1521-0111
PubMed: 32938720
DOI: 10.1124/MOLPHARM.120.000042
Page generated: Wed Aug 7 13:32:45 2024
ISSN: ESSN 1521-0111
PubMed: 32938720
DOI: 10.1124/MOLPHARM.120.000042
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