Iron in PDB 6wb6: 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta

The structure of 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta, PDB code: 6wb6 was solved by S.Lovell, M.M.Kashipathy, K.P.Battaile, J.J.Weber, M.J.Gorman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.05
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	64.493, 139.062, 146.696, 90.00, 90.00, 90.00
R / Rfree (%)	20.9 / 27.2

The binding sites of Iron atom in the 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta (pdb code 6wb6). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta, PDB code: 6wb6:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe701 b:13.9 occ:1.00 O3 A:CO3703 2.0 17.2 1.0 OH A:TYR204 2.1 17.6 1.0 O1 A:CO3703 2.1 18.0 1.0 OH A:TYR90 2.2 14.8 1.0 O3 A:CO3702 2.2 13.8 1.0 O2 A:CO3702 2.3 14.8 1.0 C A:CO3703 2.3 17.8 1.0 C A:CO3702 2.5 26.1 1.0 CZ A:TYR90 3.0 23.2 1.0 CZ A:TYR204 3.1 19.5 1.0 CE1 A:TYR204 3.5 20.6 1.0 O2 A:CO3703 3.6 18.0 1.0 CE2 A:TYR90 3.7 18.5 1.0 CE1 A:TYR90 3.7 17.1 1.0 NH1 A:ARG271 3.8 16.1 1.0 O A:HOH893 3.8 20.8 1.0 O1 A:CO3702 3.8 30.9 1.0 N A:ASN121 4.2 19.8 1.0 CE2 A:TYR204 4.2 22.4 1.0 CB A:ASN121 4.3 16.3 1.0 ND2 A:ASN121 4.4 14.3 1.0 NE A:ARG120 4.5 18.1 1.0 CB A:ARG120 4.7 16.4 1.0 NH2 A:ARG120 4.7 18.2 1.0 CD2 A:TYR90 4.8 20.1 1.0 CA A:ASN121 4.8 15.5 1.0 CD1 A:TYR90 4.8 21.2 1.0 N A:VAL122 4.9 14.1 1.0 CD1 A:TYR204 4.9 21.1 1.0 CG A:ASN121 5.0 18.4 1.0 CZ A:ARG271 5.0 19.0 1.0

Iron binding site 2 out of 2 in the 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of 2.05 A Resolution Structure of Transferrin 1 From Manduca Sexta within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe701 b:23.5 occ:1.00 OH B:TYR204 2.1 20.5 1.0 O2 B:CO3703 2.2 24.6 1.0 O3 B:CO3702 2.2 20.6 1.0 OH B:TYR90 2.2 23.6 1.0 O3 B:CO3703 2.3 26.2 1.0 O1 B:CO3702 2.5 29.4 1.0 C B:CO3703 2.5 27.0 1.0 C B:CO3702 2.7 25.0 1.0 CZ B:TYR90 2.9 21.0 1.0 CZ B:TYR204 3.0 30.9 1.0 CE1 B:TYR204 3.4 30.2 1.0 CE2 B:TYR90 3.5 24.2 1.0 CE1 B:TYR90 3.7 27.1 1.0 O1 B:CO3703 3.7 30.1 1.0 NH1 B:ARG271 3.8 24.1 1.0 O2 B:CO3702 3.8 21.2 1.0 CE2 B:TYR204 4.2 32.5 1.0 CB B:ASN121 4.3 21.9 1.0 N B:ASN121 4.3 22.6 1.0 NH2 B:ARG120 4.5 32.7 1.0 NE B:ARG120 4.6 26.3 1.0 ND2 B:ASN121 4.6 22.5 1.0 CD2 B:TYR90 4.6 27.9 1.0 CD1 B:TYR204 4.7 30.8 1.0 CD1 B:TYR90 4.8 29.6 1.0 N B:VAL122 4.8 23.1 1.0 CA B:ASN121 4.9 28.4 1.0 CB B:ARG120 5.0 25.3 1.0 CG B:ASN121 5.0 36.7 1.0

J.J.Weber, M.M.Kashipathy, K.P.Battaile, E.Go, H.Desaire, M.R.Kanost, S.Lovell, M.J.Gorman. Structural Insight Into the Novel Iron-Coordination and Domain Interactions of Transferrin-1 From A Model Insect, Manduca Sexta. Protein Sci. 2020.
ISSN: ESSN 1469-896X
PubMed: 33197096
DOI: 10.1002/PRO.3999