Iron in PDB 6y9b: Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments

The binding sites of Iron atom in the Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments (pdb code 6y9b). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 3 binding sites of Iron where determined in the Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments, PDB code: 6y9b:
Jump to Iron binding site number: 1; 2; 3;

Iron binding site 1 out of 3 in the Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe401 b:79.7 occ:1.00 FE C:HEM401 0.0 79.7 1.0 ND C:HEM401 1.9 79.7 1.0 NA C:HEM401 2.0 79.7 1.0 NE2 C:HIS175 2.0 76.3 1.0 NE2 C:HIS268 2.0 80.7 1.0 NC C:HEM401 2.1 79.7 1.0 NB C:HEM401 2.1 79.7 1.0 CD2 C:HIS268 2.8 80.7 1.0 C4D C:HEM401 2.9 79.7 1.0 C1D C:HEM401 2.9 79.7 1.0 C1A C:HEM401 2.9 79.7 1.0 CD2 C:HIS175 3.0 76.3 1.0 CE1 C:HIS175 3.0 76.3 1.0 C4C C:HEM401 3.0 79.7 1.0 C4A C:HEM401 3.0 79.7 1.0 C1B C:HEM401 3.1 79.7 1.0 C4B C:HEM401 3.1 79.7 1.0 C1C C:HEM401 3.1 79.7 1.0 CE1 C:HIS268 3.1 80.7 1.0 CHA C:HEM401 3.3 79.7 1.0 CHD C:HEM401 3.4 79.7 1.0 CHB C:HEM401 3.5 79.7 1.0 CHC C:HEM401 3.5 79.7 1.0 CG C:HIS268 4.0 80.7 1.0 ND1 C:HIS175 4.1 76.3 1.0 CG C:HIS175 4.1 76.3 1.0 C3D C:HEM401 4.1 79.7 1.0 C2D C:HEM401 4.1 79.7 1.0 ND1 C:HIS268 4.1 80.7 1.0 C2A C:HEM401 4.2 79.7 1.0 C3A C:HEM401 4.2 79.7 1.0 C3C C:HEM401 4.2 79.7 1.0 C2C C:HEM401 4.3 79.7 1.0 C2B C:HEM401 4.3 79.7 1.0 C3B C:HEM401 4.3 79.7 1.0 CB C:PRO119 4.9 84.5 1.0

Iron binding site 2 out of 3 in the Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe401 b:80.2 occ:1.00 FE A:HEM401 0.0 80.2 1.0 ND A:HEM401 1.9 80.2 1.0 NA A:HEM401 2.0 80.2 1.0 NE2 A:HIS175 2.0 76.2 1.0 NE2 A:HIS268 2.0 81.2 1.0 NC A:HEM401 2.1 80.2 1.0 NB A:HEM401 2.1 80.2 1.0 CD2 A:HIS268 2.8 81.2 1.0 C4D A:HEM401 2.9 80.2 1.0 C1D A:HEM401 2.9 80.2 1.0 C1A A:HEM401 2.9 80.2 1.0 CD2 A:HIS175 3.0 76.2 1.0 CE1 A:HIS175 3.0 76.2 1.0 C4C A:HEM401 3.0 80.2 1.0 C4A A:HEM401 3.0 80.2 1.0 C1B A:HEM401 3.1 80.2 1.0 C4B A:HEM401 3.1 80.2 1.0 C1C A:HEM401 3.1 80.2 1.0 CE1 A:HIS268 3.1 81.2 1.0 CHA A:HEM401 3.3 80.2 1.0 CHD A:HEM401 3.4 80.2 1.0 CHB A:HEM401 3.5 80.2 1.0 CHC A:HEM401 3.5 80.2 1.0 CG A:HIS268 4.0 81.2 1.0 ND1 A:HIS175 4.1 76.2 1.0 CG A:HIS175 4.1 76.2 1.0 C3D A:HEM401 4.1 80.2 1.0 C2D A:HEM401 4.1 80.2 1.0 ND1 A:HIS268 4.1 81.2 1.0 C2A A:HEM401 4.2 80.2 1.0 C3A A:HEM401 4.2 80.2 1.0 C3C A:HEM401 4.2 80.2 1.0 C2C A:HEM401 4.3 80.2 1.0 C2B A:HEM401 4.3 80.2 1.0 C3B A:HEM401 4.3 80.2 1.0 CB A:PRO119 4.9 83.6 1.0

Iron binding site 3 out of 3 in the Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Trimeric Human STEAP1 Bound to Three FAB120.545 Fragments within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe401 b:80.1 occ:1.00 FE B:HEM401 0.0 80.1 1.0 ND B:HEM401 1.9 80.1 1.0 NA B:HEM401 2.0 80.1 1.0 NE2 B:HIS175 2.0 76.8 1.0 NE2 B:HIS268 2.0 80.8 1.0 NC B:HEM401 2.1 80.1 1.0 NB B:HEM401 2.1 80.1 1.0 CD2 B:HIS268 2.8 80.8 1.0 C4D B:HEM401 2.9 80.1 1.0 C1D B:HEM401 2.9 80.1 1.0 C1A B:HEM401 2.9 80.1 1.0 CD2 B:HIS175 3.0 76.8 1.0 CE1 B:HIS175 3.0 76.8 1.0 C4C B:HEM401 3.0 80.1 1.0 C4A B:HEM401 3.0 80.1 1.0 C1B B:HEM401 3.1 80.1 1.0 C4B B:HEM401 3.1 80.1 1.0 C1C B:HEM401 3.1 80.1 1.0 CE1 B:HIS268 3.1 80.8 1.0 CHA B:HEM401 3.3 80.1 1.0 CHD B:HEM401 3.4 80.1 1.0 CHB B:HEM401 3.5 80.1 1.0 CHC B:HEM401 3.5 80.1 1.0 CG B:HIS268 4.0 80.8 1.0 ND1 B:HIS175 4.1 76.8 1.0 CG B:HIS175 4.1 76.8 1.0 C3D B:HEM401 4.1 80.1 1.0 C2D B:HEM401 4.1 80.1 1.0 ND1 B:HIS268 4.1 80.8 1.0 C2A B:HEM401 4.2 80.1 1.0 C3A B:HEM401 4.2 80.1 1.0 C3C B:HEM401 4.2 80.1 1.0 C2C B:HEM401 4.3 80.1 1.0 C2B B:HEM401 4.3 80.1 1.0 C3B B:HEM401 4.3 80.1 1.0 CB B:PRO119 4.9 84.0 1.0

W.Oosterheert, P.Gros. Structural Basis For Targeting Human Cancer Antigen STEAP1 with Antibodies J.Biol.Chem. 2020.
ISSN: ESSN 1083-351X