Iron in PDB 6zke: Complex I During Turnover, OPEN2

All present enzymatic activity of Complex I During Turnover, OPEN2:
1.6.99.3; 7.1.1.2;

The structure of Complex I During Turnover, OPEN2 also contains other interesting chemical elements:

Potassium	(K)	1 atom
Zinc	(Zn)	1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Iron atom in the Complex I During Turnover, OPEN2 (pdb code 6zke). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 28 binding sites of Iron where determined in the Complex I During Turnover, OPEN2, PDB code: 6zke:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 1:Fe501 b:29.3 occ:1.00 FE1 1:SF4501 0.0 29.3 1.0 S2 1:SF4501 2.3 27.1 1.0 S3 1:SF4501 2.3 39.6 1.0 S4 1:SF4501 2.3 70.5 1.0 SG 1:CYS365 2.3 25.7 1.0 FE2 1:SF4501 2.7 44.9 1.0 FE3 1:SF4501 2.7 34.6 1.0 CB 1:CYS365 2.8 18.6 1.0 FE4 1:SF4501 2.8 39.4 1.0 OG 1:SER358 3.3 30.5 1.0 S1 1:SF4501 4.2 56.9 1.0 CD2 1:LEU407 4.2 41.0 1.0 CA 1:CYS365 4.3 28.4 1.0 N 1:CYS359 4.3 30.2 1.0 CB 1:SER358 4.4 32.0 1.0 CA 1:SER358 4.6 35.3 1.0 C 1:CYS365 4.7 31.0 1.0 CB 1:LEU407 4.7 27.9 1.0 N 1:ARG366 4.8 29.8 1.0 N 1:GLY360 4.8 27.2 1.0 C 1:SER358 4.8 40.4 1.0 SG 1:CYS362 4.9 40.1 1.0 CG 1:LEU407 5.0 38.1 1.0

Iron binding site 2 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 1:Fe501 b:44.9 occ:1.00 FE2 1:SF4501 0.0 44.9 1.0 S3 1:SF4501 2.3 39.6 1.0 S1 1:SF4501 2.3 56.9 1.0 S4 1:SF4501 2.4 70.5 1.0 FE3 1:SF4501 2.5 34.6 1.0 FE4 1:SF4501 2.5 39.4 1.0 FE1 1:SF4501 2.7 29.3 1.0 SG 1:CYS362 3.0 40.1 1.0 N 1:CYS362 3.3 27.5 1.0 CB 1:CYS362 3.7 34.3 1.0 S2 1:SF4501 3.8 27.1 1.0 CA 1:CYS362 4.0 23.4 1.0 CB 1:CYS365 4.1 18.6 1.0 CB 1:GLN361 4.1 25.9 1.0 O 1:CYS362 4.2 21.3 1.0 N 1:GLN361 4.2 27.9 1.0 C 1:GLN361 4.3 28.5 1.0 CA 1:GLN361 4.4 48.3 1.0 C 1:CYS362 4.5 19.0 1.0 SG 1:CYS365 4.6 25.7 1.0 CB 1:ILE404 4.6 34.4 1.0 N 1:ILE404 4.6 34.1 1.0 CD1 1:ILE404 4.7 25.6 1.0 CG1 1:ILE404 4.9 29.9 1.0 SG 1:CYS359 4.9 42.9 1.0

Iron binding site 3 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 1:Fe501 b:34.6 occ:1.00 FE3 1:SF4501 0.0 34.6 1.0 S4 1:SF4501 2.3 70.5 1.0 S1 1:SF4501 2.3 56.9 1.0 S2 1:SF4501 2.4 27.1 1.0 FE4 1:SF4501 2.4 39.4 1.0 FE2 1:SF4501 2.5 44.9 1.0 FE1 1:SF4501 2.7 29.3 1.0 SG 1:CYS359 2.9 42.9 1.0 S3 1:SF4501 3.7 39.6 1.0 N 1:CYS359 3.8 30.2 1.0 CD 1:PRO203 3.9 27.2 1.0 CB 1:CYS359 3.9 28.3 1.0 CB 1:GLN361 4.1 25.9 1.0 N 1:GLN361 4.1 27.9 1.0 CG 1:PRO203 4.3 32.0 1.0 CA 1:CYS359 4.3 33.3 1.0 N 1:GLY360 4.4 27.2 1.0 C 1:CYS359 4.5 30.4 1.0 OE1 1:GLN361 4.6 29.1 1.0 CG1 1:ILE185 4.6 32.9 1.0 CA 1:GLN361 4.7 48.3 1.0 SG 1:CYS405 4.8 37.4 1.0 N 1:CYS362 4.8 27.5 1.0 CD1 1:ILE185 4.8 47.5 1.0 C 1:SER358 5.0 40.4 1.0 SG 1:CYS365 5.0 25.7 1.0 OG 1:SER358 5.0 30.5 1.0

Iron binding site 4 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 1:Fe501 b:39.4 occ:1.00 FE4 1:SF4501 0.0 39.4 1.0 S2 1:SF4501 2.3 27.1 1.0 S1 1:SF4501 2.3 56.9 1.0 S3 1:SF4501 2.3 39.6 1.0 FE3 1:SF4501 2.4 34.6 1.0 FE2 1:SF4501 2.5 44.9 1.0 FE1 1:SF4501 2.8 29.3 1.0 SG 1:CYS405 3.0 37.4 1.0 N 1:CYS405 3.7 29.4 1.0 S4 1:SF4501 3.9 70.5 1.0 CB 1:CYS405 3.9 28.4 1.0 CG 1:PRO203 4.2 32.0 1.0 CA 1:CYS405 4.2 30.4 1.0 O 1:CYS405 4.5 31.6 1.0 C 1:CYS405 4.5 28.4 1.0 CD 1:PRO203 4.6 27.2 1.0 CB 1:LEU407 4.6 27.9 1.0 CB 1:ILE404 4.6 34.4 1.0 N 1:ILE404 4.7 34.1 1.0 CD1 1:ILE185 4.7 47.5 1.0 C 1:ILE404 4.8 32.2 1.0 SG 1:CYS362 4.9 40.1 1.0 CB 1:PRO203 4.9 30.5 1.0 SG 1:CYS365 4.9 25.7 1.0 CA 1:ILE404 4.9 32.4 1.0 CB 1:CYS365 5.0 18.6 1.0 N 1:LEU407 5.0 31.8 1.0

Iron binding site 5 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 2:Fe300 b:0.6 occ:1.00 FE1 2:FES300 0.0 0.6 1.0 S1 2:FES300 2.2 58.5 1.0 S2 2:FES300 2.2 55.4 1.0 SG 2:CYS103 2.3 47.2 1.0 SG 2:CYS108 2.3 50.1 1.0 FE2 2:FES300 3.0 53.4 1.0 CB 2:CYS108 3.3 44.8 1.0 CB 2:CYS103 3.3 41.8 1.0 OG1 2:THR105 3.7 57.4 1.0 N 2:CYS108 4.2 45.4 1.0 CA 2:CYS144 4.3 40.2 1.0 CA 2:CYS108 4.3 46.8 1.0 N 2:LEU145 4.4 36.6 1.0 CA 2:CYS103 4.6 43.1 1.0 C 2:CYS103 4.6 36.9 1.0 SD 2:MET153 4.6 66.9 1.0 SG 2:CYS144 4.7 62.0 1.0 O 2:CYS103 4.7 45.5 1.0 CB 2:CYS144 4.7 55.5 1.0 N 2:THR105 4.9 41.5 1.0 C 2:CYS144 4.9 38.8 1.0 SG 2:CYS148 4.9 55.6 1.0 CG 2:MET153 4.9 62.5 1.0 CB 2:THR105 5.0 42.0 1.0

Iron binding site 6 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 2:Fe300 b:53.4 occ:1.00 FE2 2:FES300 0.0 53.4 1.0 S2 2:FES300 2.2 55.4 1.0 S1 2:FES300 2.2 58.5 1.0 SG 2:CYS148 2.3 55.6 1.0 SG 2:CYS144 2.3 62.0 1.0 FE1 2:FES300 3.0 0.6 1.0 CB 2:CYS144 3.4 55.5 1.0 CB 2:CYS148 3.7 58.9 1.0 N 2:GLY146 3.7 39.9 1.0 CA 2:CYS144 3.8 40.2 1.0 CA 2:CYS148 4.0 49.8 1.0 N 2:LEU145 4.0 36.6 1.0 N 2:CYS148 4.1 52.2 1.0 N 2:ALA147 4.1 47.9 1.0 CA 2:GLY146 4.2 39.1 1.0 C 2:CYS144 4.2 38.8 1.0 N 1:GLY103 4.2 42.0 1.0 OG1 2:THR105 4.3 57.4 1.0 CA 1:PRO102 4.3 47.6 1.0 SG 2:CYS103 4.6 47.2 1.0 C 2:GLY146 4.6 45.6 1.0 C 2:ALA147 4.7 53.2 1.0 C 2:LEU145 4.7 42.5 1.0 SG 2:CYS108 4.8 50.1 1.0 C 1:PRO102 4.9 45.5 1.0 CB 1:PRO102 4.9 53.1 1.0 CA 2:LEU145 5.0 38.1 1.0

Iron binding site 7 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 3:Fe801 b:82.8 occ:1.00 FE1 3:SF4801 0.0 82.8 1.0 S2 3:SF4801 2.3 82.8 1.0 S3 3:SF4801 2.3 82.8 1.0 S4 3:SF4801 2.3 82.8 1.0 SG 3:CYS114 2.3 32.5 1.0 FE4 3:SF4801 2.7 82.8 1.0 FE2 3:SF4801 2.7 82.8 1.0 FE3 3:SF4801 2.7 82.8 1.0 CB 3:CYS114 3.3 27.6 1.0 S1 3:SF4801 3.9 82.8 1.0 CG 3:GLN117 4.1 25.2 1.0 NE2 3:HIS101 4.2 54.0 1.0 CB 3:LEU116 4.4 22.0 1.0 CB 3:GLN110 4.4 21.5 1.0 CD 3:GLN117 4.5 25.2 1.0 N 3:GLN117 4.5 63.4 1.0 CG 3:GLN110 4.5 26.0 1.0 CD2 3:LEU116 4.7 16.4 1.0 N 3:GLY206 4.7 16.1 1.0 CA 3:CYS114 4.7 29.9 1.0 SG 3:CYS108 4.8 21.9 1.0 NE2 3:GLN117 4.8 27.5 1.0 SG 3:CYS105 4.8 36.3 1.0 CB 3:GLN117 4.8 36.0 1.0 CA 3:VAL205 4.8 21.7 1.0 CE1 3:HIS101 5.0 66.7 1.0 CG 3:LEU116 5.0 26.1 1.0

Iron binding site 8 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 3:Fe801 b:82.8 occ:1.00 FE2 3:SF4801 0.0 82.8 1.0 S4 3:SF4801 2.3 82.8 1.0 S1 3:SF4801 2.3 82.8 1.0 S3 3:SF4801 2.3 82.8 1.0 SG 3:CYS105 2.3 36.3 1.0 FE3 3:SF4801 2.7 82.8 1.0 FE1 3:SF4801 2.7 82.8 1.0 FE4 3:SF4801 2.7 82.8 1.0 CB 3:CYS105 3.3 16.6 1.0 CA 3:CYS105 3.5 13.2 1.0 NE2 3:GLN117 3.7 27.5 1.0 N 3:CYS105 3.7 18.4 1.0 S2 3:SF4801 3.9 82.8 1.0 CG 3:GLN117 4.0 25.2 1.0 CE 4:MET342 4.1 23.2 1.0 CD 3:GLN117 4.2 25.2 1.0 NE2 3:HIS101 4.3 54.0 1.0 C 3:ASP104 4.6 19.9 1.0 CD2 3:HIS101 4.7 48.9 1.0 SG 3:CYS108 4.8 21.9 1.0 SG 3:CYS114 4.8 32.5 1.0 CB 3:CYS108 4.8 12.4 1.0 C 3:CYS105 4.8 22.7 1.0 CG1 4:ILE346 4.9 25.5 1.0

Iron binding site 9 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 3:Fe801 b:82.8 occ:1.00 FE3 3:SF4801 0.0 82.8 1.0 NE2 3:HIS101 1.8 54.0 1.0 S2 3:SF4801 2.3 82.8 1.0 S1 3:SF4801 2.3 82.8 1.0 S4 3:SF4801 2.3 82.8 1.0 FE2 3:SF4801 2.7 82.8 1.0 FE1 3:SF4801 2.7 82.8 1.0 FE4 3:SF4801 2.7 82.8 1.0 CE1 3:HIS101 2.8 66.7 1.0 CD2 3:HIS101 2.8 48.9 1.0 S3 3:SF4801 3.9 82.8 1.0 ND1 3:HIS101 3.9 41.6 1.0 CG 3:HIS101 4.0 59.7 1.0 CD2 3:LEU116 4.1 16.4 1.0 CE 4:MET342 4.4 23.2 1.0 O 3:PRO102 4.5 32.8 1.0 SG 3:CYS105 4.7 36.3 1.0 SG 3:CYS114 4.8 32.5 1.0 CG 3:ARG152 4.8 50.7 1.0 SG 3:CYS108 4.8 21.9 1.0 CB 3:ARG152 4.9 40.9 1.0

Iron binding site 10 out of 28 in the Complex I During Turnover, OPEN2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Complex I During Turnover, OPEN2 within 5.0Å range: probe atom residue distance (Å) B Occ 3:Fe801 b:82.8 occ:1.00 FE4 3:SF4801 0.0 82.8 1.0 S2 3:SF4801 2.3 82.8 1.0 S3 3:SF4801 2.3 82.8 1.0 S1 3:SF4801 2.3 82.8 1.0 SG 3:CYS108 2.3 21.9 1.0 FE1 3:SF4801 2.7 82.8 1.0 FE2 3:SF4801 2.7 82.8 1.0 FE3 3:SF4801 2.7 82.8 1.0 CB 3:CYS108 3.1 12.4 1.0 S4 3:SF4801 3.9 82.8 1.0 CB 3:GLN110 4.1 21.5 1.0 N 3:GLY206 4.3 16.1 1.0 CD 3:ARG152 4.4 68.8 1.0 NE2 3:HIS101 4.5 54.0 1.0 CA 3:CYS105 4.5 13.2 1.0 CA 3:CYS108 4.5 20.9 1.0 CA 3:GLY206 4.6 20.1 1.0 N 3:CYS105 4.7 18.4 1.0 NE 3:ARG152 4.7 58.6 1.0 SG 3:CYS114 4.7 32.5 1.0 N 3:GLY111 4.8 18.5 1.0 N 3:GLN110 4.8 21.9 1.0 SG 3:CYS105 4.8 36.3 1.0 CA 3:GLN110 4.9 23.3 1.0 C 3:ASP104 4.9 19.9 1.0 C 3:GLN110 5.0 22.4 1.0 C 3:CYS108 5.0 18.8 1.0 O 3:ASP104 5.0 22.8 1.0 CG 3:ARG152 5.0 50.7 1.0

D.Kampjut, L.A.Sazanov. The Coupling Mechanism of Mammalian Respiratory Complex I. Science V. 370 2020.
ISSN: ESSN 1095-9203
PubMed: 32972993
DOI: 10.1126/SCIENCE.ABC4209