Iron in PDB 6zr2: Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A

All present enzymatic activity of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A:
7.1.1.2;

The structure of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Iron atom in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A (pdb code 6zr2). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 28 binding sites of Iron where determined in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A, PDB code: 6zr2:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:19.5 occ:1.00 FE1 B:SF4201 0.0 19.5 1.0 SG B:CYS129 2.3 18.1 1.0 S2 B:SF4201 2.3 19.5 1.0 S3 B:SF4201 2.3 19.5 1.0 S4 B:SF4201 2.3 19.5 1.0 FE4 B:SF4201 2.7 19.5 1.0 FE3 B:SF4201 2.7 19.5 1.0 FE2 B:SF4201 2.8 19.5 1.0 CB B:CYS129 3.1 18.1 1.0 S1 B:SF4201 3.9 19.5 1.0 OG1 B:THR101 3.9 19.6 1.0 N B:CYS129 4.2 18.1 1.0 CA B:CYS129 4.2 18.1 1.0 SG B:CYS159 4.6 17.9 1.0 SG B:CYS64 4.9 20.0 1.0 SG B:CYS65 4.9 19.7 1.0 OG B:SER128 5.0 18.0 1.0 NH2 D:2MR85 5.0 19.9 1.0

Iron binding site 2 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:19.5 occ:1.00 FE2 B:SF4201 0.0 19.5 1.0 S1 B:SF4201 2.3 19.5 1.0 S3 B:SF4201 2.3 19.5 1.0 S4 B:SF4201 2.3 19.5 1.0 SG B:CYS65 2.3 19.7 1.0 FE4 B:SF4201 2.7 19.5 1.0 FE3 B:SF4201 2.8 19.5 1.0 FE1 B:SF4201 2.8 19.5 1.0 CB B:CYS65 3.5 19.7 1.0 S2 B:SF4201 3.9 19.5 1.0 N B:CYS65 3.9 19.7 1.0 CA B:CYS65 4.2 19.7 1.0 CA B:PRO160 4.3 19.1 1.0 CA B:CYS159 4.4 17.9 1.0 CA B:GLY127 4.5 18.4 1.0 CB B:PRO160 4.5 19.1 1.0 N B:PRO160 4.7 19.1 1.0 CB B:CYS64 4.7 20.0 1.0 SG B:CYS64 4.8 20.0 1.0 SG B:CYS129 4.8 18.1 1.0 SG B:CYS159 4.8 17.9 1.0 O B:GLY158 4.8 17.8 1.0 C B:CYS159 4.9 17.9 1.0 C B:CYS64 4.9 20.0 1.0 CB B:CYS129 4.9 18.1 1.0

Iron binding site 3 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:19.5 occ:1.00 FE3 B:SF4201 0.0 19.5 1.0 S2 B:SF4201 2.3 19.5 1.0 S4 B:SF4201 2.3 19.5 1.0 S1 B:SF4201 2.3 19.5 1.0 SG B:CYS64 2.3 20.0 1.0 FE4 B:SF4201 2.7 19.5 1.0 FE1 B:SF4201 2.7 19.5 1.0 FE2 B:SF4201 2.8 19.5 1.0 CB B:CYS64 3.1 20.0 1.0 CE1 D:HIS190 3.8 18.9 1.0 S3 B:SF4201 3.9 19.5 1.0 N B:CYS64 3.9 20.0 1.0 CA B:CYS64 4.1 20.0 1.0 CQ2 D:2MR85 4.2 19.9 1.0 N B:CYS65 4.2 19.7 1.0 CG D:ARG105 4.5 18.2 1.0 C B:CYS64 4.6 20.0 1.0 ND1 D:HIS190 4.6 18.9 1.0 NE2 D:HIS190 4.7 18.9 1.0 SG B:CYS65 4.8 19.7 1.0 CB B:ALA63 4.8 20.6 1.0 SG B:CYS129 4.8 18.1 1.0 SG B:CYS159 4.8 17.9 1.0 NH2 D:2MR85 5.0 19.9 1.0

Iron binding site 4 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:19.5 occ:1.00 FE4 B:SF4201 0.0 19.5 1.0 SG B:CYS159 2.3 17.9 1.0 S1 B:SF4201 2.3 19.5 1.0 S2 B:SF4201 2.3 19.5 1.0 S3 B:SF4201 2.3 19.5 1.0 FE1 B:SF4201 2.7 19.5 1.0 FE3 B:SF4201 2.7 19.5 1.0 FE2 B:SF4201 2.7 19.5 1.0 CB B:CYS159 3.3 17.9 1.0 CA B:CYS159 3.3 17.9 1.0 C B:CYS159 3.7 17.9 1.0 S4 B:SF4201 3.9 19.5 1.0 NE D:ARG105 4.0 18.2 1.0 O B:CYS159 4.1 17.9 1.0 N B:PRO160 4.2 19.1 1.0 CE1 D:HIS190 4.3 18.9 1.0 ND1 D:HIS190 4.4 18.9 1.0 OG B:SER128 4.6 18.0 1.0 CA B:PRO160 4.6 19.1 1.0 CD D:ARG105 4.6 18.2 1.0 SG B:CYS129 4.6 18.1 1.0 N B:CYS159 4.7 17.9 1.0 O B:GLY158 4.7 17.8 1.0 NH2 D:ARG105 4.7 18.2 1.0 CZ D:ARG105 4.8 18.2 1.0 SG B:CYS64 4.8 20.0 1.0 CG D:ARG105 4.8 18.2 1.0 SG B:CYS65 4.9 19.7 1.0 CD B:PRO160 5.0 19.1 1.0

Iron binding site 5 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:50.4 occ:1.00 FE1 E:FES301 0.0 50.4 1.0 S2 E:FES301 2.2 50.4 1.0 S1 E:FES301 2.2 50.4 1.0 SG E:CYS103 2.3 47.5 1.0 SG E:CYS108 2.3 49.6 1.0 FE2 E:FES301 2.7 50.4 1.0 CB E:CYS103 3.3 47.5 1.0 OG1 E:THR105 3.3 45.8 1.0 CB E:CYS108 3.4 49.6 1.0 CA E:CYS144 4.2 45.8 1.0 N E:CYS108 4.4 49.6 1.0 CA E:CYS148 4.5 49.9 1.0 CA E:CYS108 4.5 49.6 1.0 N E:LEU145 4.6 47.3 1.0 SG E:CYS144 4.6 45.8 1.0 O E:ALA151 4.6 51.5 1.0 SG E:CYS148 4.6 49.9 1.0 CB E:CYS144 4.7 45.8 1.0 CA E:CYS103 4.7 47.5 1.0 CB E:CYS148 4.7 49.9 1.0 CB E:THR105 4.8 45.8 1.0 C E:PRO107 4.8 47.4 1.0 CB E:PRO107 4.9 47.4 1.0 C E:CYS144 4.9 45.8 1.0 N E:CYS144 4.9 45.8 1.0

Iron binding site 6 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:50.4 occ:1.00 FE2 E:FES301 0.0 50.4 1.0 S2 E:FES301 2.2 50.4 1.0 S1 E:FES301 2.2 50.4 1.0 SG E:CYS148 2.3 49.9 1.0 SG E:CYS144 2.3 45.8 1.0 FE1 E:FES301 2.7 50.4 1.0 CB E:CYS148 3.2 49.9 1.0 CB E:CYS144 3.3 45.8 1.0 CA E:CYS148 3.6 49.9 1.0 CA E:CYS144 3.6 45.8 1.0 N E:LEU145 3.6 47.3 1.0 N E:CYS148 3.8 49.9 1.0 N E:GLY146 3.9 47.6 1.0 C E:CYS144 4.1 45.8 1.0 N F:GLY103 4.3 48.1 1.0 SG E:CYS103 4.3 47.5 1.0 OG1 E:THR105 4.4 45.8 1.0 SG E:CYS108 4.4 49.6 1.0 CA F:PRO102 4.5 44.5 1.0 N E:ALA147 4.6 49.6 1.0 C E:ALA147 4.6 49.6 1.0 CA E:LEU145 4.7 47.3 1.0 CA E:GLY146 4.7 47.6 1.0 C E:LEU145 4.7 47.3 1.0 N E:CYS144 4.8 45.8 1.0 C F:PRO102 4.9 44.5 1.0 C E:GLY146 5.0 47.6 1.0 CB E:PRO107 5.0 47.4 1.0 CG E:PRO107 5.0 47.4 1.0

Iron binding site 7 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:33.6 occ:1.00 FE1 F:SF4502 0.0 33.6 1.0 SG F:CYS362 2.3 30.0 1.0 S4 F:SF4502 2.3 33.6 1.0 S3 F:SF4502 2.3 33.6 1.0 S2 F:SF4502 2.3 33.6 1.0 FE2 F:SF4502 2.7 33.6 1.0 FE4 F:SF4502 2.7 33.6 1.0 FE3 F:SF4502 2.7 33.6 1.0 CB F:CYS362 3.4 30.0 1.0 S1 F:SF4502 3.9 33.6 1.0 O F:CYS362 4.0 30.0 1.0 CB F:CYS365 4.0 30.6 1.0 N F:CYS362 4.0 30.0 1.0 CA F:CYS362 4.1 30.0 1.0 C F:CYS362 4.4 30.0 1.0 N F:ILE404 4.4 31.2 1.0 SG F:CYS365 4.5 30.6 1.0 CB F:THR403 4.6 30.7 1.0 CG2 F:THR403 4.7 30.7 1.0 SG F:CYS359 4.7 32.8 1.0 N F:CYS405 4.8 34.5 1.0 CB F:ILE404 4.8 31.2 1.0 SG F:CYS405 4.8 34.5 1.0 N F:CYS365 5.0 30.6 1.0

Iron binding site 8 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:33.6 occ:1.00 FE2 F:SF4502 0.0 33.6 1.0 SG F:CYS365 2.2 30.6 1.0 S1 F:SF4502 2.3 33.6 1.0 S3 F:SF4502 2.3 33.6 1.0 S4 F:SF4502 2.3 33.6 1.0 FE1 F:SF4502 2.7 33.6 1.0 FE4 F:SF4502 2.7 33.6 1.0 FE3 F:SF4502 2.7 33.6 1.0 CB F:CYS365 2.8 30.6 1.0 OG F:SER358 3.2 33.9 1.0 S2 F:SF4502 3.9 33.6 1.0 CD2 F:LEU407 4.1 36.5 1.0 CA F:CYS365 4.2 30.6 1.0 CB F:SER358 4.3 33.9 1.0 N F:CYS359 4.3 32.8 1.0 CB F:LEU407 4.3 36.5 1.0 CA F:SER358 4.5 33.9 1.0 C F:CYS365 4.5 30.6 1.0 SG F:CYS362 4.6 30.0 1.0 SG F:CYS405 4.6 34.5 1.0 CG F:LEU407 4.7 36.5 1.0 SG F:CYS359 4.8 32.8 1.0 N F:GLY360 4.8 31.1 1.0 O F:CYS365 4.8 30.6 1.0 N F:GLY408 4.9 35.4 1.0 N F:CYS365 4.9 30.6 1.0 C F:SER358 4.9 33.9 1.0

Iron binding site 9 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:33.6 occ:1.00 FE3 F:SF4502 0.0 33.6 1.0 SG F:CYS405 2.3 34.5 1.0 S4 F:SF4502 2.3 33.6 1.0 S2 F:SF4502 2.3 33.6 1.0 S1 F:SF4502 2.3 33.6 1.0 FE2 F:SF4502 2.7 33.6 1.0 FE4 F:SF4502 2.7 33.6 1.0 FE1 F:SF4502 2.7 33.6 1.0 CB F:CYS405 3.3 34.5 1.0 S3 F:SF4502 3.9 33.6 1.0 CB F:LEU407 4.0 36.5 1.0 N F:CYS405 4.0 34.5 1.0 CA F:CYS405 4.1 34.5 1.0 CD1 F:ILE185 4.3 37.3 1.0 CG F:PRO203 4.4 34.4 1.0 C F:CYS405 4.5 34.5 1.0 N F:LEU407 4.5 36.5 1.0 SG F:CYS365 4.8 30.6 1.0 SG F:CYS359 4.8 32.8 1.0 CA F:LEU407 4.8 36.5 1.0 CD F:PRO203 4.8 34.4 1.0 SG F:CYS362 4.8 30.0 1.0 O F:CYS405 4.8 34.5 1.0 N F:GLY408 5.0 35.4 1.0 CG1 F:ILE185 5.0 37.3 1.0 N F:ALA406 5.0 37.1 1.0

Iron binding site 10 out of 28 in the Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Cryo-Em Structure of Respiratory Complex I in the Active State From Mus Musculus at 3.1 A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:33.6 occ:1.00 FE4 F:SF4502 0.0 33.6 1.0 SG F:CYS359 2.2 32.8 1.0 S3 F:SF4502 2.3 33.6 1.0 S1 F:SF4502 2.3 33.6 1.0 S2 F:SF4502 2.3 33.6 1.0 FE2 F:SF4502 2.7 33.6 1.0 FE3 F:SF4502 2.7 33.6 1.0 FE1 F:SF4502 2.7 33.6 1.0 CB F:CYS359 3.3 32.8 1.0 N F:GLY360 3.6 31.1 1.0 N F:CYS359 3.7 32.8 1.0 S4 F:SF4502 3.9 33.6 1.0 CA F:CYS359 4.0 32.8 1.0 N F:GLN361 4.2 31.3 1.0 C F:CYS359 4.3 32.8 1.0 CD F:PRO203 4.3 34.4 1.0 CG F:GLN361 4.6 31.3 1.0 OG F:SER358 4.6 33.9 1.0 CA F:GLY360 4.6 31.1 1.0 N F:CYS362 4.7 30.0 1.0 SG F:CYS365 4.8 30.6 1.0 CG F:PRO203 4.8 34.4 1.0 SG F:CYS362 4.8 30.0 1.0 SG F:CYS405 4.8 34.5 1.0 C F:GLY360 4.9 31.1 1.0 C F:SER358 4.9 33.9 1.0 CG1 F:ILE185 5.0 37.3 1.0

H.R.Bridges, J.G.Fedor, J.N.Blaza, A.Di Luca, A.Jussupow, O.D.Jarman, J.J.Wright, A.A.Agip, A.P.Gamiz-Hernandez, M.M.Roessler, V.R.I.Kaila, J.Hirst. Structure of Inhibitor-Bound Mammalian Complex I. Nat Commun V. 11 5261 2020.
ISSN: ESSN 2041-1723
PubMed: 33067417
DOI: 10.1038/S41467-020-18950-3