Iron in PDB 6zvp: Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms

Enzymatic activity of Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms

All present enzymatic activity of Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms:
1.14.16.2;

Iron Binding Sites:

The binding sites of Iron atom in the Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms (pdb code 6zvp). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms, PDB code: 6zvp:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 6zvp

Go back to Iron Binding Sites List in 6zvp
Iron binding site 1 out of 4 in the Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Fe501

b:205.4
occ:1.00
 CE1 D:HIS330 1.7 292.2 1.0
OE2 D:GLU375 2.0 175.1 1.0
O1 D:LDP502 2.0 315.7 1.0
OE1 D:GLU375 2.0 229.5 1.0
NE2 D:HIS335 2.1 192.1 1.0
NE2 D:HIS330 2.2 246.0 1.0
O2 D:LDP502 2.3 132.6 1.0
CD D:GLU375 2.3 208.8 1.0
CE1 D:HIS335 2.6 305.1 1.0
C3 D:LDP502 2.9 233.2 1.0
C4 D:LDP502 3.0 198.9 1.0
ND1 D:HIS330 3.0 283.4 1.0
CD2 D:HIS335 3.1 159.4 1.0
CB D:ALA390 3.1 359.4 1.0
CD2 D:HIS330 3.5 143.6 1.0
ND1 D:HIS335 3.7 320.3 1.0
CG D:GLU375 3.8 187.5 1.0
CG D:HIS330 3.9 209.7 1.0
CG D:HIS335 3.9 224.6 1.0
N D:GLY391 4.0 181.0 1.0
C D:ALA390 4.1 183.8 1.0
C2 D:LDP502 4.2 224.0 1.0
CA D:ALA390 4.2 296.2 1.0
C5 D:LDP502 4.3 259.6 1.0
O D:ALA390 4.6 125.1 1.0
CB D:GLU375 4.6 205.4 1.0
CA D:GLY391 4.7 174.2 1.0
CA D:GLU375 4.7 254.1 1.0
OH D:TYR370 4.7 229.2 1.0

Iron binding site 2 out of 4 in 6zvp

Go back to Iron Binding Sites List in 6zvp
Iron binding site 2 out of 4 in the Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe501

b:205.4
occ:1.00
 CE1 A:HIS330 1.7 292.2 1.0
OE2 A:GLU375 2.0 175.1 1.0
O1 A:LDP502 2.0 315.7 1.0
OE1 A:GLU375 2.0 229.5 1.0
NE2 A:HIS335 2.1 192.1 1.0
NE2 A:HIS330 2.2 246.0 1.0
O2 A:LDP502 2.3 132.6 1.0
CD A:GLU375 2.3 208.8 1.0
CE1 A:HIS335 2.6 305.1 1.0
C3 A:LDP502 2.9 233.2 1.0
C4 A:LDP502 3.0 198.9 1.0
ND1 A:HIS330 3.0 283.4 1.0
CD2 A:HIS335 3.1 159.4 1.0
CB A:ALA390 3.1 359.4 1.0
CD2 A:HIS330 3.5 143.6 1.0
ND1 A:HIS335 3.7 320.3 1.0
CG A:GLU375 3.8 187.5 1.0
CG A:HIS330 3.9 209.7 1.0
CG A:HIS335 3.9 224.6 1.0
N A:GLY391 4.0 181.0 1.0
C A:ALA390 4.1 183.8 1.0
C2 A:LDP502 4.2 224.0 1.0
CA A:ALA390 4.2 296.2 1.0
C5 A:LDP502 4.3 259.6 1.0
O A:ALA390 4.6 125.1 1.0
CB A:GLU375 4.6 205.4 1.0
CA A:GLY391 4.7 174.2 1.0
CA A:GLU375 4.7 254.1 1.0
OH A:TYR370 4.8 229.2 1.0

Iron binding site 3 out of 4 in 6zvp

Go back to Iron Binding Sites List in 6zvp
Iron binding site 3 out of 4 in the Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe501

b:205.4
occ:1.00
 CE1 B:HIS330 1.7 292.2 1.0
OE2 B:GLU375 2.0 175.1 1.0
O1 B:LDP502 2.0 315.7 1.0
OE1 B:GLU375 2.0 229.5 1.0
NE2 B:HIS335 2.1 192.1 1.0
NE2 B:HIS330 2.2 246.0 1.0
O2 B:LDP502 2.3 132.6 1.0
CD B:GLU375 2.3 208.8 1.0
CE1 B:HIS335 2.6 305.1 1.0
C3 B:LDP502 2.9 233.2 1.0
C4 B:LDP502 3.0 198.9 1.0
ND1 B:HIS330 3.0 283.4 1.0
CD2 B:HIS335 3.1 159.4 1.0
CB B:ALA390 3.1 359.4 1.0
CD2 B:HIS330 3.5 143.6 1.0
ND1 B:HIS335 3.7 320.3 1.0
CG B:GLU375 3.8 187.5 1.0
CG B:HIS330 3.9 209.7 1.0
CG B:HIS335 3.9 224.6 1.0
N B:GLY391 4.0 181.0 1.0
C B:ALA390 4.1 183.8 1.0
C2 B:LDP502 4.2 224.0 1.0
CA B:ALA390 4.2 296.2 1.0
C5 B:LDP502 4.3 259.6 1.0
O B:ALA390 4.6 125.1 1.0
CB B:GLU375 4.6 205.4 1.0
CA B:GLY391 4.7 174.2 1.0
CA B:GLU375 4.7 254.1 1.0
OH B:TYR370 4.7 229.2 1.0

Iron binding site 4 out of 4 in 6zvp

Go back to Iron Binding Sites List in 6zvp
Iron binding site 4 out of 4 in the Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Atomic Model of the Em-Based Structure of the Full-Length Tyrosine Hydroxylase in Complex with Dopamine (Residues 40-497) in Which the Regulatory Domain (Residues 40-165) Has Been Included Only with the Backbone Atoms within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Fe501

b:205.4
occ:1.00
 CE1 C:HIS330 1.7 292.2 1.0
OE2 C:GLU375 2.0 175.1 1.0
O1 C:LDP502 2.0 315.7 1.0
OE1 C:GLU375 2.0 229.5 1.0
NE2 C:HIS335 2.1 192.1 1.0
NE2 C:HIS330 2.2 246.0 1.0
O2 C:LDP502 2.3 132.6 1.0
CD C:GLU375 2.3 208.8 1.0
CE1 C:HIS335 2.6 305.1 1.0
C3 C:LDP502 2.9 233.2 1.0
C4 C:LDP502 3.0 198.9 1.0
ND1 C:HIS330 3.0 283.4 1.0
CD2 C:HIS335 3.1 159.4 1.0
CB C:ALA390 3.1 359.4 1.0
CD2 C:HIS330 3.5 143.6 1.0
ND1 C:HIS335 3.7 320.3 1.0
CG C:GLU375 3.8 187.5 1.0
CG C:HIS330 3.9 209.7 1.0
CG C:HIS335 3.9 224.6 1.0
N C:GLY391 4.0 181.0 1.0
C C:ALA390 4.1 183.8 1.0
C2 C:LDP502 4.2 224.0 1.0
CA C:ALA390 4.2 296.2 1.0
C5 C:LDP502 4.3 259.6 1.0
O C:ALA390 4.6 125.1 1.0
CB C:GLU375 4.6 205.4 1.0
CA C:GLY391 4.7 174.2 1.0
CA C:GLU375 4.7 254.1 1.0
OH C:TYR370 4.8 229.2 1.0

Reference:

M.T.Bueno-Carrasco, J.Cuellar, M.I.Flydal, C.Santiago, T.A.Krakenes, R.Kleppe, J.R.Lopez-Blanco, K.Teigen, S.Alvira, P.Chacon, A.Martinez, J.M.Valpuesta. Structural Mechanism For Tyrosine Hydroxylase Inhibition By Dopamine and Reactivation By SER40 Phosphorylation To Be Published.
Page generated: Thu Nov 25 09:29:08 2021

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