Iron in PDB 7a6h: Cryo-Em Structure of Human Apo Rna Polymerase III

Enzymatic activity of Cryo-Em Structure of Human Apo Rna Polymerase III

All present enzymatic activity of Cryo-Em Structure of Human Apo Rna Polymerase III:
2.7.7.6;

Other elements in 7a6h:

The structure of Cryo-Em Structure of Human Apo Rna Polymerase III also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Zinc (Zn) 7 atoms

Iron Binding Sites:

The binding sites of Iron atom in the Cryo-Em Structure of Human Apo Rna Polymerase III (pdb code 7a6h). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Cryo-Em Structure of Human Apo Rna Polymerase III, PDB code: 7a6h:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 7a6h

Go back to Iron Binding Sites List in 7a6h
Iron binding site 1 out of 4 in the Cryo-Em Structure of Human Apo Rna Polymerase III


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Human Apo Rna Polymerase III within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:86.5
occ:1.00
FE1 P:SF4401 0.0 86.5 1.0
S2 P:SF4401 2.3 86.5 1.0
S4 P:SF4401 2.3 86.5 1.0
S3 P:SF4401 2.3 86.5 1.0
FE3 P:SF4401 2.7 86.5 1.0
FE4 P:SF4401 2.7 86.5 1.0
FE2 P:SF4401 2.7 86.5 1.0
SG P:CYS290 3.0 91.7 1.0
CB P:CYS290 3.2 91.7 1.0
S1 P:SF4401 3.9 86.5 1.0
CD2 P:TYR309 4.1 95.0 1.0
O P:PRO286 4.3 96.5 1.0
CA P:CYS290 4.4 91.7 1.0
CA P:CYS287 4.5 95.8 1.0
SG P:CYS307 4.6 94.9 1.0
CE2 P:TYR309 4.7 95.0 1.0
CB P:TYR309 4.9 95.0 1.0
CG P:TYR309 4.9 95.0 1.0
C P:PRO286 4.9 96.5 1.0

Iron binding site 2 out of 4 in 7a6h

Go back to Iron Binding Sites List in 7a6h
Iron binding site 2 out of 4 in the Cryo-Em Structure of Human Apo Rna Polymerase III


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Human Apo Rna Polymerase III within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:86.5
occ:1.00
FE2 P:SF4401 0.0 86.5 1.0
S1 P:SF4401 2.3 86.5 1.0
S3 P:SF4401 2.3 86.5 1.0
S4 P:SF4401 2.3 86.5 1.0
FE4 P:SF4401 2.7 86.5 1.0
FE3 P:SF4401 2.7 86.5 1.0
FE1 P:SF4401 2.7 86.5 1.0
SG P:CYS307 3.0 94.9 1.0
CB P:CYS307 3.2 94.9 1.0
S2 P:SF4401 3.8 86.5 1.0
CA P:CYS307 4.6 94.9 1.0
CE P:MET310 4.7 98.1 1.0
CA P:PRO304 4.7 86.4 1.0
CG P:MET310 4.8 98.1 1.0
CD2 P:TYR309 4.8 95.0 1.0
O P:SER303 4.8 89.5 1.0
SG P:CYS296 4.9 87.1 1.0

Iron binding site 3 out of 4 in 7a6h

Go back to Iron Binding Sites List in 7a6h
Iron binding site 3 out of 4 in the Cryo-Em Structure of Human Apo Rna Polymerase III


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Human Apo Rna Polymerase III within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:86.5
occ:1.00
FE3 P:SF4401 0.0 86.5 1.0
S2 P:SF4401 2.3 86.5 1.0
S4 P:SF4401 2.3 86.5 1.0
S1 P:SF4401 2.3 86.5 1.0
FE1 P:SF4401 2.7 86.5 1.0
FE2 P:SF4401 2.7 86.5 1.0
FE4 P:SF4401 2.7 86.5 1.0
SG P:CYS296 3.1 87.1 1.0
CB P:CYS296 3.2 87.1 1.0
S3 P:SF4401 3.9 86.5 1.0
SG P:CYS290 4.4 91.7 1.0
ND2 O:ASN445 4.5 93.5 1.0
CA P:CYS296 4.7 87.1 1.0
CG O:ASN445 4.9 93.5 1.0
CD1 P:PHE293 5.0 91.9 1.0
CG2 P:ILE302 5.0 89.3 1.0

Iron binding site 4 out of 4 in 7a6h

Go back to Iron Binding Sites List in 7a6h
Iron binding site 4 out of 4 in the Cryo-Em Structure of Human Apo Rna Polymerase III


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryo-Em Structure of Human Apo Rna Polymerase III within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:86.5
occ:1.00
FE4 P:SF4401 0.0 86.5 1.0
S1 P:SF4401 2.3 86.5 1.0
S3 P:SF4401 2.3 86.5 1.0
S2 P:SF4401 2.3 86.5 1.0
FE2 P:SF4401 2.7 86.5 1.0
FE1 P:SF4401 2.7 86.5 1.0
FE3 P:SF4401 2.7 86.5 1.0
SG P:CYS287 3.0 95.8 1.0
CE P:MET310 3.6 98.1 1.0
CB P:CYS287 3.8 95.8 1.0
CA P:CYS287 3.8 95.8 1.0
S4 P:SF4401 3.9 86.5 1.0
N P:CYS287 4.3 95.8 1.0
CB O:ASN445 4.4 93.5 1.0
ND2 O:ASN445 4.5 93.5 1.0
CG O:ASN445 4.7 93.5 1.0
C P:PRO286 4.8 96.5 1.0
O P:PRO286 4.8 96.5 1.0
SD P:MET310 4.9 98.1 1.0
CG P:MET310 4.9 98.1 1.0

Reference:

M.Girbig, A.D.Misiaszek, M.K.Vorlaender, A.Lafita, H.Groetsch, F.Baudin, A.Bateman, C.W.Mueller. Cryo-Em Structures of Human Rna Polymerase III in Its Unbound and Transcribing States To Be Published.
DOI: 10.1038/S41594-020-00555-5
Page generated: Wed Mar 3 14:01:33 2021

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