Iron in PDB 7aea: Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2

Enzymatic activity of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2

All present enzymatic activity of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2:
2.7.7.6;

Other elements in 7aea:

The structure of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2 also contains other interesting chemical elements:

Zinc (Zn) 7 atoms
Magnesium (Mg) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2 (pdb code 7aea). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2, PDB code: 7aea:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 7aea

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Iron binding site 1 out of 4 in the Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:153.1
occ:1.00
FE1 P:SF4401 0.0 153.1 1.0
S4 P:SF4401 2.3 153.1 1.0
S2 P:SF4401 2.3 153.1 1.0
S3 P:SF4401 2.3 153.1 1.0
FE4 P:SF4401 2.7 153.1 1.0
FE3 P:SF4401 2.7 153.1 1.0
FE2 P:SF4401 2.7 153.1 1.0
SG P:CYS290 3.1 159.1 1.0
CB P:CYS290 3.6 159.1 1.0
S1 P:SF4401 3.9 153.1 1.0
CD2 P:TYR309 4.1 161.5 1.0
SG P:CYS307 4.1 162.4 1.0
CB P:TYR309 4.3 161.5 1.0
O P:PRO286 4.4 164.4 1.0
CG P:TYR309 4.5 161.5 1.0
CE2 P:TYR309 4.9 161.5 1.0
CA P:CYS287 4.9 160.1 1.0

Iron binding site 2 out of 4 in 7aea

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Iron binding site 2 out of 4 in the Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:153.1
occ:1.00
FE2 P:SF4401 0.0 153.1 1.0
S1 P:SF4401 2.3 153.1 1.0
S3 P:SF4401 2.3 153.1 1.0
S4 P:SF4401 2.3 153.1 1.0
FE4 P:SF4401 2.7 153.1 1.0
FE1 P:SF4401 2.7 153.1 1.0
FE3 P:SF4401 2.7 153.1 1.0
SG P:CYS307 3.1 162.4 1.0
CB P:CYS307 3.5 162.4 1.0
S2 P:SF4401 3.9 153.1 1.0
CA P:PRO304 4.1 152.4 1.0
SG P:CYS296 4.3 144.4 1.0
CB P:PRO304 4.3 152.4 1.0
CE P:MET310 4.4 167.4 1.0
N P:PRO304 4.5 152.4 1.0
CG P:MET310 4.5 167.4 1.0
O P:SER303 4.6 153.0 1.0
SD P:MET310 4.6 167.4 1.0
C P:SER303 4.9 153.0 1.0
CA P:CYS307 5.0 162.4 1.0

Iron binding site 3 out of 4 in 7aea

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Iron binding site 3 out of 4 in the Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:153.1
occ:1.00
FE3 P:SF4401 0.0 153.1 1.0
S2 P:SF4401 2.3 153.1 1.0
S4 P:SF4401 2.3 153.1 1.0
S1 P:SF4401 2.3 153.1 1.0
FE4 P:SF4401 2.7 153.1 1.0
FE1 P:SF4401 2.7 153.1 1.0
FE2 P:SF4401 2.7 153.1 1.0
SG P:CYS296 3.2 144.4 1.0
CB P:CYS296 3.2 144.4 1.0
S3 P:SF4401 3.9 153.1 1.0
ND2 O:ASN445 4.6 154.5 1.0
O P:PHE293 4.7 148.8 1.0
CA P:CYS296 4.7 144.4 1.0
CA P:PHE293 4.8 148.8 1.0
O P:VAL292 4.8 152.7 1.0
CD1 P:PHE293 4.9 148.8 1.0
CG O:ASN445 5.0 154.5 1.0

Iron binding site 4 out of 4 in 7aea

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Iron binding site 4 out of 4 in the Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryo-Em Structure of Human Rna Polymerase III Elongation Complex 2 within 5.0Å range:
probe atom residue distance (Å) B Occ
P:Fe401

b:153.1
occ:1.00
FE4 P:SF4401 0.0 153.1 1.0
S3 P:SF4401 2.3 153.1 1.0
S2 P:SF4401 2.3 153.1 1.0
S1 P:SF4401 2.3 153.1 1.0
FE2 P:SF4401 2.7 153.1 1.0
FE3 P:SF4401 2.7 153.1 1.0
FE1 P:SF4401 2.7 153.1 1.0
SG P:CYS287 3.1 160.1 1.0
CA P:CYS287 3.5 160.1 1.0
CB P:CYS287 3.6 160.1 1.0
S4 P:SF4401 3.9 153.1 1.0
CE P:MET310 3.9 167.4 1.0
N P:CYS287 4.0 160.1 1.0
O P:PRO286 4.3 164.4 1.0
C P:PRO286 4.4 164.4 1.0
ND2 O:ASN445 4.6 154.5 1.0
C P:CYS287 4.7 160.1 1.0
CB O:ASN445 4.7 154.5 1.0
CG O:ASN445 4.9 154.5 1.0
O P:CYS287 4.9 160.1 1.0

Reference:

M.Girbig, A.D.Misiaszek, M.K.Vorlaender, A.Lafita, H.Groetsch, F.Baudin, A.Bateman, C.W.Mueller. Cryo-Em Structures of Human Rna Polymerase III in Its Unbound and Transcribing States To Be Published.
DOI: 10.1038/S41594-020-00555-5
Page generated: Wed Mar 3 14:01:34 2021

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