Iron in PDB 7b93: Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A

Enzymatic activity of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A

All present enzymatic activity of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A:
7.1.1.2;

Other elements in 7b93:

The structure of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A also contains other interesting chemical elements:

Zinc (Zn) 1 atom
Fluorine (F) 3 atoms

Iron Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Iron atom in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A (pdb code 7b93). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 28 binding sites of Iron where determined in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A, PDB code: 7b93:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 28 in 7b93

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Iron binding site 1 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe201

b:37.2
occ:1.00
 FE1 B:SF4201 0.0 37.2 1.0
SG B:CYS129 2.3 35.0 1.0
S3 B:SF4201 2.3 37.2 1.0
S2 B:SF4201 2.3 37.2 1.0
S4 B:SF4201 2.3 37.2 1.0
FE4 B:SF4201 2.7 37.2 1.0
FE2 B:SF4201 2.7 37.2 1.0
FE3 B:SF4201 2.8 37.2 1.0
CB B:CYS129 3.2 35.0 1.0
OG1 B:THR101 3.8 36.8 1.0
S1 B:SF4201 3.9 37.2 1.0
N B:CYS129 4.1 35.0 1.0
CA B:CYS129 4.2 35.0 1.0
CQ2 D:2MR85 4.4 36.8 1.0
NH2 D:2MR85 4.5 36.8 1.0
SG B:CYS159 4.7 34.5 1.0
SG B:CYS65 4.8 37.5 1.0
N B:THR101 4.9 36.8 1.0
OG B:SER128 4.9 33.8 1.0
CE2 B:TYR136 4.9 34.1 1.0
CA B:GLY100 4.9 36.9 1.0
SG B:CYS64 4.9 38.2 1.0

Iron binding site 2 out of 28 in 7b93

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Iron binding site 2 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe201

b:37.2
occ:1.00
 FE2 B:SF4201 0.0 37.2 1.0
S3 B:SF4201 2.3 37.2 1.0
S4 B:SF4201 2.3 37.2 1.0
S1 B:SF4201 2.3 37.2 1.0
SG B:CYS65 2.3 37.5 1.0
FE1 B:SF4201 2.7 37.2 1.0
FE4 B:SF4201 2.7 37.2 1.0
FE3 B:SF4201 2.8 37.2 1.0
CB B:CYS65 3.5 37.5 1.0
N B:CYS65 3.8 37.5 1.0
S2 B:SF4201 3.9 37.2 1.0
CA B:CYS65 4.1 37.5 1.0
CA B:PRO160 4.4 36.1 1.0
CB B:CYS64 4.5 38.2 1.0
CB B:PRO160 4.5 36.1 1.0
CA B:GLY127 4.6 35.3 1.0
CA B:CYS159 4.6 34.5 1.0
SG B:CYS64 4.7 38.2 1.0
C B:CYS64 4.8 38.2 1.0
O B:GLY158 4.8 34.7 1.0
CA B:GLY100 4.8 36.9 1.0
SG B:CYS129 4.8 35.0 1.0
CD B:PRO161 4.9 36.2 1.0
SG B:CYS159 4.9 34.5 1.0
N B:PRO160 4.9 36.1 1.0
N B:CYS64 5.0 38.2 1.0

Iron binding site 3 out of 28 in 7b93

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Iron binding site 3 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe201

b:37.2
occ:1.00
 FE3 B:SF4201 0.0 37.2 1.0
S2 B:SF4201 2.3 37.2 1.0
S1 B:SF4201 2.3 37.2 1.0
S4 B:SF4201 2.3 37.2 1.0
SG B:CYS64 2.3 38.2 1.0
FE4 B:SF4201 2.7 37.2 1.0
FE2 B:SF4201 2.8 37.2 1.0
FE1 B:SF4201 2.8 37.2 1.0
CB B:CYS64 3.0 38.2 1.0
CQ2 D:2MR85 3.4 36.8 1.0
N B:CYS64 3.8 38.2 1.0
S3 B:SF4201 3.9 37.2 1.0
CA B:CYS64 4.0 38.2 1.0
NE2 D:HIS190 4.0 37.5 1.0
N B:CYS65 4.3 37.5 1.0
NH2 D:2MR85 4.4 36.8 1.0
CG D:ARG105 4.5 35.6 1.0
CD2 D:HIS190 4.5 37.5 1.0
C B:CYS64 4.6 38.2 1.0
CB B:ALA63 4.7 38.2 1.0
SG B:CYS159 4.8 34.5 1.0
SG B:CYS129 4.8 35.0 1.0
SG B:CYS65 4.8 37.5 1.0
C B:ALA63 4.9 38.2 1.0

Iron binding site 4 out of 28 in 7b93

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Iron binding site 4 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe201

b:37.2
occ:1.00
 FE4 B:SF4201 0.0 37.2 1.0
SG B:CYS159 2.3 34.5 1.0
S1 B:SF4201 2.3 37.2 1.0
S2 B:SF4201 2.3 37.2 1.0
S3 B:SF4201 2.3 37.2 1.0
FE1 B:SF4201 2.7 37.2 1.0
FE2 B:SF4201 2.7 37.2 1.0
FE3 B:SF4201 2.7 37.2 1.0
CB B:CYS159 3.2 34.5 1.0
CA B:CYS159 3.4 34.5 1.0
C B:CYS159 3.8 34.5 1.0
S4 B:SF4201 3.9 37.2 1.0
O B:CYS159 4.2 34.5 1.0
N B:PRO160 4.3 36.1 1.0
NE D:ARG105 4.3 35.6 1.0
CD2 D:HIS190 4.5 37.5 1.0
CA B:PRO160 4.6 36.1 1.0
SG B:CYS129 4.7 35.0 1.0
CG D:ARG105 4.7 35.6 1.0
O B:GLY158 4.7 34.7 1.0
N B:CYS159 4.7 34.5 1.0
OG B:SER128 4.8 33.8 1.0
NH2 D:ARG105 4.8 35.6 1.0
SG B:CYS64 4.8 38.2 1.0
SG B:CYS65 4.8 37.5 1.0
NE2 D:HIS190 4.9 37.5 1.0
CD B:PRO160 5.0 36.1 1.0

Iron binding site 5 out of 28 in 7b93

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Iron binding site 5 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Fe301

b:65.7
occ:1.00
 FE1 E:FES301 0.0 65.7 1.0
S2 E:FES301 2.2 65.7 1.0
S1 E:FES301 2.2 65.7 1.0
SG E:CYS103 2.3 62.2 1.0
SG E:CYS108 2.3 64.3 1.0
FE2 E:FES301 2.7 65.7 1.0
CB E:CYS103 3.3 62.2 1.0
CB E:CYS108 3.3 64.3 1.0
CA E:CYS144 4.2 62.0 1.0
N E:CYS108 4.2 64.3 1.0
SD E:MET153 4.3 66.1 1.0
CA E:CYS108 4.4 64.3 1.0
N E:LEU145 4.4 62.7 1.0
CG E:MET153 4.6 66.1 1.0
CA E:CYS148 4.6 64.9 1.0
CA E:CYS103 4.6 62.2 1.0
SG E:CYS144 4.6 62.0 1.0
CB E:CYS144 4.7 62.0 1.0
SG E:CYS148 4.7 64.9 1.0
C E:CYS103 4.8 62.2 1.0
O E:ALA147 4.8 65.4 1.0
C E:CYS144 4.9 62.0 1.0
N E:CYS148 4.9 64.9 1.0
N E:CYS144 4.9 62.0 1.0
C E:ALA147 4.9 65.4 1.0
CB E:THR105 4.9 61.2 1.0
N E:THR105 5.0 61.2 1.0
O E:THR105 5.0 61.2 1.0

Iron binding site 6 out of 28 in 7b93

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Iron binding site 6 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Fe301

b:65.7
occ:1.00
 FE2 E:FES301 0.0 65.7 1.0
S2 E:FES301 2.2 65.7 1.0
S1 E:FES301 2.2 65.7 1.0
SG E:CYS148 2.3 64.9 1.0
SG E:CYS144 2.3 62.0 1.0
FE1 E:FES301 2.7 65.7 1.0
CB E:CYS144 3.2 62.0 1.0
CB E:CYS148 3.3 64.9 1.0
CA E:CYS144 3.5 62.0 1.0
CA E:CYS148 3.5 64.9 1.0
N E:CYS148 3.6 64.9 1.0
N E:LEU145 3.9 62.7 1.0
C E:CYS144 4.1 62.0 1.0
N E:GLY146 4.2 63.7 1.0
N E:ALA147 4.2 65.4 1.0
SG E:CYS103 4.2 62.2 1.0
C E:ALA147 4.3 65.4 1.0
N F:GLY103 4.4 63.8 1.0
SG E:CYS108 4.4 64.3 1.0
CB E:PRO107 4.5 62.8 1.0
CG E:PRO107 4.6 62.8 1.0
N E:CYS144 4.7 62.0 1.0
CA E:GLY146 4.8 63.7 1.0
O E:ALA147 4.8 65.4 1.0
CA F:PRO102 4.8 60.5 1.0
CA E:ALA147 4.9 65.4 1.0
C E:GLY146 4.9 63.7 1.0
C E:LEU145 5.0 62.7 1.0
C E:CYS148 5.0 64.9 1.0
CA E:LEU145 5.0 62.7 1.0

Iron binding site 7 out of 28 in 7b93

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Iron binding site 7 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Fe502

b:47.8
occ:1.00
 FE1 F:SF4502 0.0 47.8 1.0
SG F:CYS362 2.3 44.5 1.0
S4 F:SF4502 2.3 47.8 1.0
S3 F:SF4502 2.3 47.8 1.0
S2 F:SF4502 2.3 47.8 1.0
FE2 F:SF4502 2.7 47.8 1.0
FE3 F:SF4502 2.7 47.8 1.0
FE4 F:SF4502 2.7 47.8 1.0
CB F:CYS362 3.4 44.5 1.0
S1 F:SF4502 3.9 47.8 1.0
N F:CYS362 3.9 44.5 1.0
O F:CYS362 4.0 44.5 1.0
CB F:CYS365 4.0 46.5 1.0
CA F:CYS362 4.1 44.5 1.0
N F:ILE404 4.4 45.0 1.0
C F:CYS362 4.4 44.5 1.0
SG F:CYS365 4.5 46.5 1.0
CB F:THR403 4.6 45.0 1.0
CG2 F:THR403 4.7 45.0 1.0
SG F:CYS359 4.7 49.1 1.0
CB F:ILE404 4.7 45.0 1.0
SG F:CYS405 4.8 48.9 1.0
N F:CYS405 4.8 48.9 1.0
CG F:GLN361 4.9 46.7 1.0
C F:GLN361 5.0 46.7 1.0
N F:GLN361 5.0 46.7 1.0

Iron binding site 8 out of 28 in 7b93

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Iron binding site 8 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Fe502

b:47.8
occ:1.00
 FE2 F:SF4502 0.0 47.8 1.0
SG F:CYS365 2.2 46.5 1.0
S3 F:SF4502 2.3 47.8 1.0
S4 F:SF4502 2.3 47.8 1.0
S1 F:SF4502 2.3 47.8 1.0
FE1 F:SF4502 2.7 47.8 1.0
FE4 F:SF4502 2.7 47.8 1.0
FE3 F:SF4502 2.7 47.8 1.0
CB F:CYS365 2.8 46.5 1.0
OG F:SER358 3.5 49.8 1.0
S2 F:SF4502 3.9 47.8 1.0
CB F:SER358 4.2 49.8 1.0
CA F:CYS365 4.3 46.5 1.0
N F:CYS359 4.3 49.1 1.0
CD2 F:LEU407 4.3 51.9 1.0
CA F:SER358 4.5 49.8 1.0
SG F:CYS362 4.6 44.5 1.0
SG F:CYS405 4.7 48.9 1.0
N F:ARG366 4.7 44.2 1.0
N F:GLY360 4.7 46.3 1.0
CB F:LEU407 4.7 51.9 1.0
SG F:CYS359 4.8 49.1 1.0
C F:CYS365 4.8 46.5 1.0
C F:SER358 4.9 49.8 1.0
CG F:LEU407 4.9 51.9 1.0
N F:CYS365 5.0 46.5 1.0
CD1 F:LEU407 5.0 51.9 1.0

Iron binding site 9 out of 28 in 7b93

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Iron binding site 9 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Fe502

b:47.8
occ:1.00
 FE3 F:SF4502 0.0 47.8 1.0
SG F:CYS405 2.3 48.9 1.0
S4 F:SF4502 2.3 47.8 1.0
S2 F:SF4502 2.3 47.8 1.0
S1 F:SF4502 2.3 47.8 1.0
FE4 F:SF4502 2.7 47.8 1.0
FE1 F:SF4502 2.7 47.8 1.0
FE2 F:SF4502 2.7 47.8 1.0
CB F:CYS405 3.4 48.9 1.0
S3 F:SF4502 3.9 47.8 1.0
N F:CYS405 4.1 48.9 1.0
CB F:LEU407 4.1 51.9 1.0
CA F:CYS405 4.2 48.9 1.0
CD1 F:ILE185 4.4 52.9 1.0
C F:CYS405 4.6 48.9 1.0
N F:LEU407 4.7 51.9 1.0
CG F:PRO203 4.7 49.5 1.0
SG F:CYS359 4.7 49.1 1.0
SG F:CYS362 4.8 44.5 1.0
SG F:CYS365 4.8 46.5 1.0
O F:CYS405 4.9 48.9 1.0
N F:GLY408 4.9 50.8 1.0
CA F:LEU407 4.9 51.9 1.0
CB F:CYS365 5.0 46.5 1.0

Iron binding site 10 out of 28 in 7b93

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Iron binding site 10 out of 28 in the Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Cryo-Em Structure of Mitochondrial Complex I From Mus Musculus Inhibited By Iacs-2858 at 3.0 A within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Fe502

b:47.8
occ:1.00
 FE4 F:SF4502 0.0 47.8 1.0
SG F:CYS359 2.2 49.1 1.0
S3 F:SF4502 2.3 47.8 1.0
S1 F:SF4502 2.3 47.8 1.0
S2 F:SF4502 2.3 47.8 1.0
FE3 F:SF4502 2.7 47.8 1.0
FE2 F:SF4502 2.7 47.8 1.0
FE1 F:SF4502 2.7 47.8 1.0
CB F:CYS359 3.3 49.1 1.0
N F:GLY360 3.6 46.3 1.0
N F:CYS359 3.7 49.1 1.0
S4 F:SF4502 3.9 47.8 1.0
CA F:CYS359 3.9 49.1 1.0
N F:GLN361 4.1 46.7 1.0
C F:CYS359 4.2 49.1 1.0
CG F:GLN361 4.3 46.7 1.0
CD F:PRO203 4.5 49.5 1.0
OG F:SER358 4.6 49.8 1.0
CA F:GLY360 4.6 46.3 1.0
N F:CYS362 4.8 44.5 1.0
SG F:CYS365 4.8 46.5 1.0
SG F:CYS405 4.8 48.9 1.0
CG F:PRO203 4.9 49.5 1.0
SG F:CYS362 4.9 44.5 1.0
C F:SER358 4.9 49.8 1.0
C F:GLY360 4.9 46.3 1.0
NE2 F:GLN361 5.0 46.7 1.0

Reference:

I.Chung, R.Serreli, J.B.Cross, M.E.Di Francesco, J.R.Marszalek, J.Hirst. Cork-in-Bottle Mechanism of Inhibitor Binding to Mammalian Complex I. Sci Adv V. 7 2021.
ISSN: ESSN 2375-2548
PubMed: 33990335
DOI: 10.1126/SCIADV.ABG4000
Page generated: Sat Jul 10 15:11:45 2021

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