Iron in PDB 7du2: Rna Polymerase III Ec Complex in Post-Translocation State

All present enzymatic activity of Rna Polymerase III Ec Complex in Post-Translocation State:
2.7.7.6;

The structure of Rna Polymerase III Ec Complex in Post-Translocation State also contains other interesting chemical elements:

Zinc	(Zn)	6 atoms
Magnesium	(Mg)	1 atom

The binding sites of Iron atom in the Rna Polymerase III Ec Complex in Post-Translocation State (pdb code 7du2). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Rna Polymerase III Ec Complex in Post-Translocation State, PDB code: 7du2:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Rna Polymerase III Ec Complex in Post-Translocation State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Rna Polymerase III Ec Complex in Post-Translocation State within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE1 P:SF4401 0.0 119.5 1.0 S2 P:SF4401 2.1 119.5 1.0 S3 P:SF4401 2.1 119.5 1.0 S4 P:SF4401 2.1 119.5 1.0 SG P:CYS287 2.6 121.3 1.0 FE4 P:SF4401 3.0 119.5 1.0 FE3 P:SF4401 3.0 119.5 1.0 FE2 P:SF4401 3.0 119.5 1.0 CB P:CYS287 3.1 121.3 1.0 S1 P:SF4401 3.7 119.5 1.0 CB O:ASN445 3.9 118.3 1.0 CA P:CYS287 4.0 121.3 1.0 OD1 O:ASN445 4.1 118.3 1.0 CG O:ASN445 4.3 118.3 1.0 SG P:CYS290 4.7 126.7 1.0 CG P:MET310 4.8 121.4 1.0 O P:CYS287 4.9 121.3 1.0 CB P:PRO304 5.0 112.1 1.0 SD P:MET310 5.0 121.4 1.0 N P:CYS287 5.0 121.3 1.0

Iron binding site 2 out of 4 in the Rna Polymerase III Ec Complex in Post-Translocation State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Rna Polymerase III Ec Complex in Post-Translocation State within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE2 P:SF4401 0.0 119.5 1.0 S3 P:SF4401 2.1 119.5 1.0 S4 P:SF4401 2.1 119.5 1.0 S1 P:SF4401 2.1 119.5 1.0 CD2 P:PHE293 2.6 122.0 1.0 CB P:CYS307 3.0 120.8 1.0 FE3 P:SF4401 3.0 119.5 1.0 FE1 P:SF4401 3.0 119.5 1.0 FE4 P:SF4401 3.0 119.5 1.0 SG P:CYS307 3.2 120.8 1.0 CE2 P:PHE293 3.3 122.0 1.0 CG P:PHE293 3.7 122.0 1.0 S2 P:SF4401 3.7 119.5 1.0 CB P:PHE293 4.0 122.0 1.0 CD2 P:TYR309 4.4 119.9 1.0 CA P:CYS307 4.5 120.8 1.0 CB P:TYR309 4.6 119.9 1.0 CZ P:PHE293 4.7 122.0 1.0 O P:PHE293 4.7 122.0 1.0 CA P:PRO304 4.8 112.1 1.0 SG P:CYS290 4.9 126.7 1.0 CB P:PRO304 4.9 112.1 1.0 CD1 P:PHE293 4.9 122.0 1.0

Iron binding site 3 out of 4 in the Rna Polymerase III Ec Complex in Post-Translocation State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Rna Polymerase III Ec Complex in Post-Translocation State within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE3 P:SF4401 0.0 119.5 1.0 S2 P:SF4401 2.1 119.5 1.0 S1 P:SF4401 2.1 119.5 1.0 S4 P:SF4401 2.1 119.5 1.0 O P:PHE293 2.4 122.0 1.0 FE2 P:SF4401 3.0 119.5 1.0 FE1 P:SF4401 3.0 119.5 1.0 FE4 P:SF4401 3.0 119.5 1.0 C P:PHE293 3.0 122.0 1.0 CB P:PHE293 3.3 122.0 1.0 CA P:PHE293 3.7 122.0 1.0 S3 P:SF4401 3.7 119.5 1.0 N P:ASP294 3.9 118.9 1.0 SG P:CYS287 3.9 121.3 1.0 SG P:CYS290 3.9 126.7 1.0 CD2 P:PHE293 4.0 122.0 1.0 CG P:PHE293 4.1 122.0 1.0 CA P:ASP294 4.2 118.9 1.0 OD1 O:ASN445 4.3 118.3 1.0 SG P:CYS296 4.5 104.7 1.0 C P:ASP294 4.8 118.9 1.0 O P:ASP294 4.9 118.9 1.0 NZ O:LYS441 4.9 114.0 1.0 N P:PHE293 5.0 122.0 1.0 CG O:ASN445 5.0 118.3 1.0

Iron binding site 4 out of 4 in the Rna Polymerase III Ec Complex in Post-Translocation State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Rna Polymerase III Ec Complex in Post-Translocation State within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE4 P:SF4401 0.0 119.5 1.0 S1 P:SF4401 2.1 119.5 1.0 S2 P:SF4401 2.1 119.5 1.0 S3 P:SF4401 2.1 119.5 1.0 CB P:PRO304 2.5 112.1 1.0 FE1 P:SF4401 3.0 119.5 1.0 FE2 P:SF4401 3.0 119.5 1.0 FE3 P:SF4401 3.0 119.5 1.0 CG O:ASN445 3.2 118.3 1.0 CA P:PRO304 3.2 112.1 1.0 OD1 O:ASN445 3.3 118.3 1.0 ND2 O:ASN445 3.4 118.3 1.0 CG P:PRO304 3.4 112.1 1.0 CB O:ASN445 3.7 118.3 1.0 S4 P:SF4401 3.7 119.5 1.0 N P:PRO304 3.8 112.1 1.0 CD P:PRO304 3.8 112.1 1.0 SG P:CYS296 4.2 104.7 1.0 O P:ILE302 4.5 111.4 1.0 C P:PRO304 4.5 112.1 1.0 O P:PHE293 4.5 122.0 1.0 CB P:CYS307 4.7 120.8 1.0 C P:SER303 4.7 113.1 1.0 CB P:CYS296 4.7 104.7 1.0 O P:PRO304 4.8 112.1 1.0 CA O:ASN445 5.0 118.3 1.0

L.Li, Z.Yu, D.Zhao, Y.Ren, H.Hou, Y.Xu. Structure of Human Rna Polymerase III Elongation Complex. Cell Res. 2021.
ISSN: ISSN 1001-0602
PubMed: 33674783
DOI: 10.1038/S41422-021-00472-2