Atomistry » Iron » PDB 7kvp-7lvz » 7lhr
Atomistry »
  Iron »
    PDB 7kvp-7lvz »
      7lhr »

Iron in PDB 7lhr: Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis

Enzymatic activity of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis

All present enzymatic activity of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis:
1.8.4.8;

Protein crystallography data

The structure of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis, PDB code: 7lhr was solved by P.R.Feliciano, C.L.Drennan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.25 / 3.11
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.414, 77.414, 204.352, 90, 90, 90
R / Rfree (%) 20.7 / 24.9

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis (pdb code 7lhr). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis, PDB code: 7lhr:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Iron binding site 1 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 1 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe301

b:87.2
occ:1.00
 FE1 A:SF4301 0.0 87.2 1.0
S4 A:SF4301 2.3 82.2 1.0
SG A:CYS223 2.3 116.0 1.0
S2 A:SF4301 2.3 94.3 1.0
S3 A:SF4301 2.3 101.2 1.0
FE2 A:SF4301 2.7 93.1 1.0
FE3 A:SF4301 2.7 87.2 1.0
FE4 A:SF4301 2.7 98.5 1.0
CB A:CYS223 3.0 102.6 1.0
S1 A:SF4301 3.9 88.5 1.0
OG1 A:THR90 4.2 83.9 1.0
CA A:CYS223 4.4 95.2 1.0
CD2 A:TYR92 4.7 110.8 1.0
CB A:THR90 4.7 83.1 1.0
SG A:CYS226 4.7 114.4 1.0
CB A:TYR92 4.7 102.7 1.0
N A:CYS223 4.8 100.0 1.0
CG2 A:THR90 4.8 80.7 1.0
SG A:CYS141 4.8 99.0 1.0
SG A:CYS140 4.9 98.3 1.0

Iron binding site 2 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 2 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe301

b:93.1
occ:1.00
 FE2 A:SF4301 0.0 93.1 1.0
S3 A:SF4301 2.3 101.2 1.0
SG A:CYS141 2.3 99.0 1.0
S1 A:SF4301 2.3 88.5 1.0
S4 A:SF4301 2.3 82.2 1.0
FE4 A:SF4301 2.7 98.5 1.0
FE1 A:SF4301 2.7 87.2 1.0
FE3 A:SF4301 2.7 87.2 1.0
CB A:CYS141 3.4 91.2 1.0
CA A:CYS141 3.6 87.9 1.0
N A:CYS141 3.8 80.7 1.0
S2 A:SF4301 3.9 94.3 1.0
CE A:LYS145 4.3 109.0 1.0
O A:PRO137 4.4 146.2 1.0
C A:CYS140 4.4 81.0 1.0
NZ A:LYS145 4.6 95.9 1.0
SG A:CYS140 4.7 98.3 1.0
SG A:CYS223 4.7 116.0 1.0
SG A:CYS226 4.7 114.4 1.0
CB A:CYS140 4.8 94.5 1.0
CD A:LYS145 4.8 104.2 1.0
O A:CYS140 4.8 79.5 1.0
C A:CYS141 5.0 104.1 1.0

Iron binding site 3 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 3 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe301

b:87.2
occ:1.00
 FE3 A:SF4301 0.0 87.2 1.0
S2 A:SF4301 2.3 94.3 1.0
S4 A:SF4301 2.3 82.2 1.0
SG A:CYS140 2.3 98.3 1.0
S1 A:SF4301 2.3 88.5 1.0
FE1 A:SF4301 2.7 87.2 1.0
FE2 A:SF4301 2.7 93.1 1.0
FE4 A:SF4301 2.7 98.5 1.0
CB A:CYS140 3.2 94.5 1.0
S3 A:SF4301 3.9 101.2 1.0
CB A:PHE133 3.9 124.7 1.0
C A:CYS140 3.9 81.0 1.0
N A:CYS141 4.1 80.7 1.0
CA A:CYS140 4.2 84.7 1.0
O A:CYS140 4.2 79.5 1.0
CD2 A:TYR92 4.4 110.8 1.0
CE2 A:TYR92 4.6 117.5 1.0
CA A:CYS141 4.6 87.9 1.0
CA A:PHE133 4.6 129.8 1.0
SG A:CYS141 4.7 99.0 1.0
CD A:ARG144 4.8 98.5 1.0
SG A:CYS226 4.8 114.4 1.0
SG A:CYS223 4.9 116.0 1.0
O A:PRO137 4.9 146.2 1.0

Iron binding site 4 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 4 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe301

b:98.5
occ:1.00
 FE4 A:SF4301 0.0 98.5 1.0
S1 A:SF4301 2.3 88.5 1.0
SG A:CYS226 2.3 114.4 1.0
S3 A:SF4301 2.3 101.2 1.0
S2 A:SF4301 2.3 94.3 1.0
FE2 A:SF4301 2.7 93.1 1.0
FE3 A:SF4301 2.7 87.2 1.0
FE1 A:SF4301 2.7 87.2 1.0
CB A:CYS226 3.3 109.8 1.0
S4 A:SF4301 3.9 82.2 1.0
CB A:PHE133 4.0 124.7 1.0
CB A:CYS223 4.4 102.6 1.0
CA A:CYS226 4.6 113.9 1.0
SG A:CYS223 4.7 116.0 1.0
SG A:CYS141 4.7 99.0 1.0
N A:CYS226 4.7 111.3 1.0
SG A:CYS140 4.7 98.3 1.0
CG A:PHE133 4.9 127.4 1.0
CA A:PHE133 5.0 129.8 1.0

Iron binding site 5 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 5 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe301

b:86.7
occ:1.00
 FE1 B:SF4301 0.0 86.7 1.0
S4 B:SF4301 2.3 78.4 1.0
S3 B:SF4301 2.3 76.3 1.0
S2 B:SF4301 2.3 77.1 1.0
SG B:CYS223 2.3 89.5 1.0
FE2 B:SF4301 2.7 85.0 1.0
FE3 B:SF4301 2.7 81.5 1.0
FE4 B:SF4301 2.7 74.6 1.0
CB B:CYS223 3.0 77.4 1.0
S1 B:SF4301 3.9 83.6 1.0
CE B:LYS145 4.0 117.8 1.0
OG1 B:THR90 4.2 67.5 1.0
NZ B:LYS145 4.3 121.7 1.0
CA B:CYS223 4.4 65.3 1.0
CB B:THR90 4.6 68.5 1.0
SG B:CYS226 4.7 72.9 1.0
CG2 B:THR90 4.7 68.3 1.0
CB B:TYR92 4.8 95.6 1.0
SG B:CYS141 4.8 92.7 1.0
SG B:CYS140 4.8 111.9 1.0
N B:CYS223 4.9 69.0 1.0
CD2 B:TYR92 4.9 91.2 1.0
CD B:LYS145 4.9 100.7 1.0

Iron binding site 6 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 6 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe301

b:85.0
occ:1.00
 FE2 B:SF4301 0.0 85.0 1.0
SG B:CYS226 2.2 72.9 1.0
S4 B:SF4301 2.3 78.4 1.0
S3 B:SF4301 2.3 76.3 1.0
S1 B:SF4301 2.3 83.6 1.0
FE1 B:SF4301 2.7 86.7 1.0
FE4 B:SF4301 2.7 74.6 1.0
FE3 B:SF4301 2.7 81.5 1.0
CB B:CYS226 3.2 75.2 1.0
S2 B:SF4301 3.9 77.1 1.0
CB B:PHE133 4.0 106.2 1.0
CB B:CYS223 4.3 77.4 1.0
CA B:CYS226 4.5 75.3 1.0
N B:CYS226 4.6 72.9 1.0
SG B:CYS223 4.6 89.5 1.0
SG B:CYS141 4.7 92.7 1.0
SG B:CYS140 4.7 111.9 1.0
CG B:PHE133 4.9 106.3 1.0

Iron binding site 7 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 7 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe301

b:81.5
occ:1.00
 FE3 B:SF4301 0.0 81.5 1.0
SG B:CYS141 2.3 92.7 1.0
S2 B:SF4301 2.3 77.1 1.0
S1 B:SF4301 2.3 83.6 1.0
S4 B:SF4301 2.3 78.4 1.0
FE4 B:SF4301 2.7 74.6 1.0
FE1 B:SF4301 2.7 86.7 1.0
FE2 B:SF4301 2.7 85.0 1.0
CB B:CYS141 3.5 90.0 1.0
CA B:CYS141 3.6 82.7 1.0
N B:CYS141 3.8 86.3 1.0
S3 B:SF4301 3.9 76.3 1.0
CE B:LYS145 4.4 117.8 1.0
C B:CYS140 4.4 96.6 1.0
O B:PRO137 4.5 110.0 1.0
NZ B:LYS145 4.6 121.7 1.0
CD B:LYS145 4.6 100.7 1.0
SG B:CYS140 4.6 111.9 1.0
SG B:CYS226 4.7 72.9 1.0
SG B:CYS223 4.7 89.5 1.0
CB B:CYS140 4.8 112.3 1.0
O B:CYS140 4.8 100.4 1.0
CG B:LYS145 4.9 93.5 1.0

Iron binding site 8 out of 8 in 7lhr

Go back to Iron Binding Sites List in 7lhr
Iron binding site 8 out of 8 in the Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Crystal Structure of Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe301

b:74.6
occ:1.00
 FE4 B:SF4301 0.0 74.6 1.0
SG B:CYS140 2.3 111.9 1.0
S1 B:SF4301 2.3 83.6 1.0
S2 B:SF4301 2.3 77.1 1.0
S3 B:SF4301 2.3 76.3 1.0
FE3 B:SF4301 2.7 81.5 1.0
FE2 B:SF4301 2.7 85.0 1.0
FE1 B:SF4301 2.7 86.7 1.0
CB B:CYS140 3.2 112.3 1.0
S4 B:SF4301 3.9 78.4 1.0
C B:CYS140 3.9 96.6 1.0
CB B:PHE133 4.0 106.2 1.0
N B:CYS141 4.1 86.3 1.0
CA B:CYS140 4.2 106.4 1.0
O B:CYS140 4.2 100.4 1.0
CA B:CYS141 4.6 82.7 1.0
CD2 B:TYR92 4.6 91.2 1.0
SG B:CYS141 4.7 92.7 1.0
CA B:PHE133 4.7 105.8 1.0
CD B:ARG144 4.7 77.8 1.0
SG B:CYS226 4.8 72.9 1.0
SG B:CYS223 4.9 89.5 1.0
CE2 B:TYR92 4.9 94.6 1.0
O B:PRO137 4.9 110.0 1.0

Reference:

P.R.Feliciano, K.S.Carroll, C.L.Drennan. Crystal Structure of the [4FE-4S] Cluster-Containing Adenosine-5'-Phosphosulfate Reductase From Mycobacterium Tuberculosis . Acs Omega V. 6 13756 2021.
ISSN: ESSN 2470-1343
PubMed: 34095667
DOI: 10.1021/ACSOMEGA.1C01043
Page generated: Thu Aug 8 06:58:31 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy