Iron in PDB 7n7h: X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis

The structure of X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis, PDB code: 7n7h was solved by T.L.Grove, S.C.Almo, J.B.Bonanno, J.C.Lachowicz, A.G.Gizzi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.11 / 1.42
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	36.875, 50.533, 137.746, 90, 90, 90
R / Rfree (%)	15.2 / 17.2

The structure of X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Iron atom in the X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis (pdb code 7n7h). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis, PDB code: 7n7h:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe301 b:11.3 occ:1.00 FE1 A:SF4301 0.0 11.3 1.0 S4 A:SF4301 2.2 12.3 1.0 SG A:CYS14 2.2 11.6 1.0 S2 A:SF4301 2.3 10.9 1.0 S3 A:SF4301 2.3 10.9 1.0 FE3 A:SF4301 2.7 11.7 1.0 FE2 A:SF4301 2.7 10.7 1.0 FE4 A:SF4301 2.7 11.6 1.0 CB A:CYS14 3.2 12.2 1.0 N A:SAM302 3.7 12.4 1.0 S1 A:SF4301 3.8 10.8 1.0 O A:HOH672 4.2 15.2 1.0 CB A:TYR16 4.2 12.6 1.0 O A:HOH459 4.6 19.6 1.0 N A:TYR16 4.6 11.5 1.0 O A:HOH463 4.7 12.3 1.0 O A:TYR16 4.7 14.5 1.0 CA A:CYS14 4.7 10.8 1.0 C A:TYR16 4.7 13.7 1.0 O A:SAM302 4.7 11.1 1.0 SG A:CYS21 4.7 11.1 1.0 ND2 A:ASN88 4.7 10.6 1.0 CA A:TYR16 4.8 12.3 1.0 SG A:CYS18 4.8 12.3 1.0 C A:GLY56 4.9 11.2 1.0

Iron binding site 2 out of 4 in the X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe301 b:10.7 occ:1.00 FE2 A:SF4301 0.0 10.7 1.0 S3 A:SF4301 2.2 10.9 1.0 S1 A:SF4301 2.3 10.8 1.0 SG A:CYS18 2.3 12.3 1.0 S4 A:SF4301 2.3 12.3 1.0 FE1 A:SF4301 2.7 11.3 1.0 FE3 A:SF4301 2.7 11.7 1.0 FE4 A:SF4301 2.8 11.6 1.0 CB A:CYS18 3.1 11.1 1.0 NH1 A:ARG124 3.6 13.9 1.0 S2 A:SF4301 3.9 10.9 1.0 N A:CYS18 4.0 11.8 1.0 O A:SAM302 4.1 11.1 1.0 CZ A:ARG124 4.1 12.6 1.0 CA A:CYS18 4.2 11.9 1.0 CB A:TYR16 4.2 12.6 1.0 NH2 A:ARG124 4.6 12.9 1.0 SG A:CYS14 4.7 11.6 1.0 NE A:ARG124 4.7 14.1 1.0 SG A:CYS21 4.7 11.1 1.0 N A:SAM302 4.8 12.4 1.0 CB A:CYS21 4.8 9.4 1.0 CD A:ARG124 4.9 16.6 1.0 CD2 A:TYR16 5.0 14.5 1.0

Iron binding site 3 out of 4 in the X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe301 b:11.7 occ:1.00 FE3 A:SF4301 0.0 11.7 1.0 S2 A:SF4301 2.2 10.9 1.0 SG A:CYS21 2.3 11.1 1.0 S1 A:SF4301 2.3 10.8 1.0 S4 A:SF4301 2.3 12.3 1.0 FE1 A:SF4301 2.7 11.3 1.0 FE2 A:SF4301 2.7 10.7 1.0 FE4 A:SF4301 2.9 11.6 1.0 CB A:CYS21 3.2 9.4 1.0 O A:HOH672 3.8 15.2 1.0 S3 A:SF4301 3.9 10.9 1.0 CE A:SAM302 4.0 20.9 1.0 CA A:CYS21 4.2 9.4 1.0 O A:HIS23 4.5 10.8 1.0 O A:HOH463 4.6 12.3 1.0 CB A:CYS18 4.6 11.1 1.0 N A:SAM302 4.7 12.4 1.0 SD A:SAM302 4.7 15.6 1.0 SG A:CYS18 4.7 12.3 1.0 O A:SAM302 4.8 11.1 1.0 SG A:CYS14 4.8 11.6 1.0 C8 A:SAM302 5.0 9.9 1.0 NH1 A:ARG195 5.0 24.7 1.0

Iron binding site 4 out of 4 in the X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of X-Ray Crystal Structure of Viperin-Like Enzyme From Nematostella Vectensis within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe301 b:11.6 occ:1.00 FE4 A:SF4301 0.0 11.6 1.0 O A:SAM302 2.1 11.1 1.0 N A:SAM302 2.2 12.4 1.0 S1 A:SF4301 2.3 10.8 1.0 S3 A:SF4301 2.3 10.9 1.0 S2 A:SF4301 2.4 10.9 1.0 FE1 A:SF4301 2.7 11.3 1.0 FE2 A:SF4301 2.8 10.7 1.0 FE3 A:SF4301 2.9 11.7 1.0 C A:SAM302 2.9 11.7 1.0 CA A:SAM302 3.1 11.5 1.0 SD A:SAM302 3.4 15.6 1.0 CG A:SAM302 3.7 15.3 1.0 CE A:SAM302 3.9 20.9 1.0 CB A:SAM302 3.9 14.2 1.0 NH1 A:ARG124 4.0 13.9 1.0 S4 A:SF4301 4.0 12.3 1.0 OXT A:SAM302 4.2 10.8 1.0 SG A:CYS14 4.5 11.6 1.0 O A:GLY56 4.6 11.7 1.0 C2' A:SAM302 4.9 9.9 1.0 SG A:CYS18 4.9 12.3 1.0 CZ A:ARG124 5.0 12.6 1.0

J.C.Lachowicz, A.G.Gizzi, S.C.Almo, T.L.Grove. Structural Insight Into the Substrate Scope of Viperin and Viperin-Like Enzymes From Three Domains of Life To Be Published.