Iron in PDB 7ne3: Human TET2 in Complex with Favourable Dna Substrate.

The structure of Human TET2 in Complex with Favourable Dna Substrate., PDB code: 7ne3 was solved by D.Rafalski, M.Bochtler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.86 / 2.26
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	47.994, 87.711, 260.531, 90, 90, 90
R / Rfree (%)	17.5 / 22.6

The structure of Human TET2 in Complex with Favourable Dna Substrate. also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

The binding sites of Iron atom in the Human TET2 in Complex with Favourable Dna Substrate. (pdb code 7ne3). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Human TET2 in Complex with Favourable Dna Substrate., PDB code: 7ne3:

Iron binding site 1 out of 1 in the Human TET2 in Complex with Favourable Dna Substrate.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human TET2 in Complex with Favourable Dna Substrate. within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe2004 b:44.6 occ:1.00 NE2 A:HIS1881 2.2 39.6 1.0 O2' A:OGA2005 2.3 55.5 1.0 NE2 A:HIS1382 2.3 51.1 1.0 O1 A:OGA2005 2.3 55.3 1.0 O A:HOH2203 2.4 52.7 1.0 OD1 A:ASP1384 2.4 48.4 1.0 C2 A:OGA2005 3.0 47.6 1.0 C1 A:OGA2005 3.0 48.6 1.0 OD2 A:ASP1384 3.1 59.6 1.0 CG A:ASP1384 3.1 53.3 1.0 CE1 A:HIS1881 3.2 45.5 1.0 CE1 A:HIS1382 3.2 50.6 1.0 CD2 A:HIS1881 3.2 43.8 1.0 CD2 A:HIS1382 3.3 53.6 1.0 O A:HOH2111 4.1 60.3 1.0 O2 A:OGA2005 4.2 54.2 1.0 ND1 A:HIS1881 4.3 45.8 1.0 ND1 A:HIS1382 4.3 55.3 1.0 N1 A:OGA2005 4.3 52.9 1.0 O A:HOH2106 4.3 52.6 1.0 CG A:HIS1881 4.3 39.4 1.0 CG A:HIS1382 4.4 54.2 1.0 NH2 A:ARG1261 4.4 46.7 1.0 CB A:ALA1876 4.5 41.1 1.0 CB A:ASP1384 4.5 48.4 1.0 C5A B:5CM6 4.7 51.6 1.0 C4 A:OGA2005 4.9 46.8 1.0 N A:ASP1384 4.9 44.7 1.0

M.Ravichandran, D.Rafalski, C.I.Davies, O.Ortega-Recalde, X.Nan, C.R.Glanfield, A.Kotter, K.Misztal, A.H.Wang, M.Wojciechowski, M.Razew, I.M.Mayyas, O.Kardailsky, U.Schwartz, K.Zembrzycki, I.M.Morison, M.Helm, D.Weichenhan, R.Z.Jurkowska, F.Krueger, C.Plass, M.Zacharias, M.Bochtler, T.A.Hore, T.P.Jurkowski. Pronounced Sequence Specificity of the Tet Enzyme Catalytic Domain Guides Its Cellular Function. Sci Adv V. 8 M2427 2022.
ISSN: ESSN 2375-2548
PubMed: 36070377
DOI: 10.1126/SCIADV.ABM2427