Iron in PDB 7nvw: Tfiih in A Pre-Translocated State (Without Adp-BEF3)

All present enzymatic activity of Tfiih in A Pre-Translocated State (Without Adp-BEF3):
3.6.4.12;

The structure of Tfiih in A Pre-Translocated State (Without Adp-BEF3) also contains other interesting chemical elements:

Zinc

(Zn)

7 atoms

The binding sites of Iron atom in the Tfiih in A Pre-Translocated State (Without Adp-BEF3) (pdb code 7nvw). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Tfiih in A Pre-Translocated State (Without Adp-BEF3), PDB code: 7nvw:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Tfiih in A Pre-Translocated State (Without Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Tfiih in A Pre-Translocated State (Without Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:168.3 occ:1.00 FE1 0:SF41000 0.0 168.3 1.0 SG 0:CYS190 2.2 69.8 1.0 S4 0:SF41000 2.3 168.3 1.0 S3 0:SF41000 2.3 168.3 1.0 S2 0:SF41000 2.3 168.3 1.0 FE4 0:SF41000 2.7 168.3 1.0 FE3 0:SF41000 2.7 168.3 1.0 FE2 0:SF41000 2.7 168.3 1.0 CB 0:CYS190 3.7 69.8 1.0 S1 0:SF41000 3.9 168.3 1.0 CE1 0:PHE193 4.0 64.0 1.0 CD1 0:PHE193 4.1 64.0 1.0 CA 0:CYS190 4.5 69.8 1.0 CB 0:PHE157 4.6 63.3 1.0 SG 0:CYS155 4.6 65.4 1.0 N 0:TYR158 4.7 64.3 1.0 SG 0:CYS134 4.8 62.6 1.0 SG 0:CYS116 4.8 63.3 1.0 CB 0:TYR158 4.9 64.3 1.0

Iron binding site 2 out of 4 in the Tfiih in A Pre-Translocated State (Without Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Tfiih in A Pre-Translocated State (Without Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:168.3 occ:1.00 FE2 0:SF41000 0.0 168.3 1.0 SG 0:CYS116 2.3 63.3 1.0 S3 0:SF41000 2.3 168.3 1.0 S4 0:SF41000 2.3 168.3 1.0 S1 0:SF41000 2.3 168.3 1.0 FE3 0:SF41000 2.7 168.3 1.0 FE4 0:SF41000 2.7 168.3 1.0 FE1 0:SF41000 2.7 168.3 1.0 CB 0:CYS116 3.7 63.3 1.0 S2 0:SF41000 3.9 168.3 1.0 CB 0:HIS118 4.1 73.0 1.0 N 0:HIS118 4.3 73.0 1.0 N 0:ILE117 4.3 62.4 1.0 CA 0:CYS116 4.5 63.3 1.0 CG2 0:VAL121 4.7 69.9 1.0 SG 0:CYS134 4.7 62.6 1.0 SG 0:CYS155 4.8 65.4 1.0 SG 0:CYS190 4.8 69.8 1.0 CA 0:HIS118 4.9 73.0 1.0 C 0:CYS116 4.9 63.3 1.0

Iron binding site 3 out of 4 in the Tfiih in A Pre-Translocated State (Without Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Tfiih in A Pre-Translocated State (Without Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:168.3 occ:1.00 FE3 0:SF41000 0.0 168.3 1.0 SG 0:CYS134 2.3 62.6 1.0 S2 0:SF41000 2.3 168.3 1.0 S1 0:SF41000 2.3 168.3 1.0 S4 0:SF41000 2.3 168.3 1.0 FE2 0:SF41000 2.7 168.3 1.0 FE1 0:SF41000 2.7 168.3 1.0 FE4 0:SF41000 2.7 168.3 1.0 CB 0:CYS134 3.5 62.6 1.0 S3 0:SF41000 3.9 168.3 1.0 CA 0:CYS134 4.2 62.6 1.0 CE1 0:PHE193 4.2 64.0 1.0 SG 0:CYS116 4.7 63.3 1.0 O 0:CYS134 4.7 62.6 1.0 SG 0:CYS190 4.8 69.8 1.0 SG 0:CYS155 4.8 65.4 1.0 C 0:CYS134 4.9 62.6 1.0 CZ 0:PHE193 4.9 64.0 1.0

Iron binding site 4 out of 4 in the Tfiih in A Pre-Translocated State (Without Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Tfiih in A Pre-Translocated State (Without Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:168.3 occ:1.00 FE4 0:SF41000 0.0 168.3 1.0 SG 0:CYS155 2.2 65.4 1.0 S2 0:SF41000 2.3 168.3 1.0 S1 0:SF41000 2.3 168.3 1.0 S3 0:SF41000 2.3 168.3 1.0 FE1 0:SF41000 2.7 168.3 1.0 FE2 0:SF41000 2.7 168.3 1.0 FE3 0:SF41000 2.7 168.3 1.0 CB 0:CYS155 3.7 65.4 1.0 S4 0:SF41000 3.9 168.3 1.0 CB 0:HIS118 4.1 73.0 1.0 CD2 0:PHE157 4.3 63.3 1.0 CG 0:HIS118 4.4 73.0 1.0 CD2 0:HIS118 4.5 73.0 1.0 SG 0:CYS190 4.6 69.8 1.0 CB 0:PHE157 4.7 63.3 1.0 SG 0:CYS116 4.7 63.3 1.0 SG 0:CYS134 4.8 62.6 1.0 CA 0:CYS155 5.0 65.4 1.0 N 0:TYR158 5.0 64.3 1.0

S.Aibara, S.Schilbach, P.Cramer. Structures of Mammalian Rna Polymerase II Pre-Initiation Complexes. Nature 2021.
ISSN: ESSN 1476-4687
PubMed: 33902107
DOI: 10.1038/S41586-021-03554-8