Iron in PDB 7o37: Murine Supercomplex CIII2CIV in the Assembled Locked Conformation

All present enzymatic activity of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation:
7.1.1.8; 7.1.1.9;

The structure of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation also contains other interesting chemical elements:

Sodium	(Na)	1 atom
Copper	(Cu)	3 atoms
Magnesium	(Mg)	1 atom
Zinc	(Zn)	1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Iron atom in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation (pdb code 7o37). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 12 binding sites of Iron where determined in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation, PDB code: 7o37:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe401 b:28.4 occ:1.00 FE C:HEM401 0.0 28.4 1.0 NA C:HEM401 2.0 27.9 1.0 NC C:HEM401 2.0 31.1 1.0 ND C:HEM401 2.0 34.3 1.0 NB C:HEM401 2.0 31.1 1.0 NE2 C:HIS83 2.1 25.5 1.0 NE2 C:HIS182 2.1 24.3 1.0 CE1 C:HIS83 2.8 21.0 1.0 CE1 C:HIS182 2.9 24.7 1.0 C4D C:HEM401 3.0 35.4 1.0 C1A C:HEM401 3.0 32.3 1.0 C4C C:HEM401 3.0 31.9 1.0 C1D C:HEM401 3.0 34.6 1.0 C1B C:HEM401 3.0 32.5 1.0 C4B C:HEM401 3.0 27.9 1.0 C4A C:HEM401 3.1 29.3 1.0 C1C C:HEM401 3.1 30.3 1.0 CD2 C:HIS83 3.2 28.5 1.0 CD2 C:HIS182 3.3 22.1 1.0 CHA C:HEM401 3.4 33.0 1.0 CHD C:HEM401 3.4 29.8 1.0 CHB C:HEM401 3.4 31.0 1.0 CHC C:HEM401 3.5 27.5 1.0 ND1 C:HIS83 4.0 20.0 1.0 ND1 C:HIS182 4.1 25.0 1.0 C2A C:HEM401 4.2 33.1 1.0 C3C C:HEM401 4.2 42.4 1.0 C2B C:HEM401 4.2 28.3 1.0 C3A C:HEM401 4.2 27.1 1.0 C2C C:HEM401 4.2 32.3 1.0 C3D C:HEM401 4.2 43.0 1.0 CG C:HIS83 4.2 25.8 1.0 C2D C:HEM401 4.2 45.8 1.0 C3B C:HEM401 4.3 33.0 1.0 CG C:HIS182 4.3 25.3 1.0 CA C:GLY130 4.8 29.0 1.0

Iron binding site 2 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe402 b:20.9 occ:1.00 FE C:HEM402 0.0 20.9 1.0 NA C:HEM402 2.0 38.8 1.0 NC C:HEM402 2.0 26.7 1.0 ND C:HEM402 2.0 30.4 1.0 NB C:HEM402 2.0 34.6 1.0 NE2 C:HIS196 2.1 30.2 1.0 NE2 C:HIS97 2.2 19.0 1.0 C4D C:HEM402 3.0 34.1 1.0 C1A C:HEM402 3.0 37.3 1.0 C1D C:HEM402 3.0 30.0 1.0 C4C C:HEM402 3.0 28.9 1.0 C1B C:HEM402 3.0 35.4 1.0 C4B C:HEM402 3.0 36.9 1.0 C4A C:HEM402 3.0 44.3 1.0 C1C C:HEM402 3.0 28.9 1.0 CE1 C:HIS196 3.1 32.9 1.0 CD2 C:HIS97 3.1 20.5 1.0 CD2 C:HIS196 3.1 32.8 1.0 CE1 C:HIS97 3.2 23.2 1.0 CHA C:HEM402 3.4 41.0 1.0 CHD C:HEM402 3.4 32.7 1.0 CHB C:HEM402 3.4 41.0 1.0 CHC C:HEM402 3.5 34.3 1.0 ND1 C:HIS196 4.2 33.6 1.0 C2A C:HEM402 4.2 41.3 1.0 C3C C:HEM402 4.2 27.3 1.0 CG C:HIS196 4.2 33.0 1.0 C3A C:HEM402 4.2 42.2 1.0 C2C C:HEM402 4.2 32.1 1.0 C2B C:HEM402 4.2 31.6 1.0 C2D C:HEM402 4.2 23.0 1.0 C3D C:HEM402 4.2 26.8 1.0 C3B C:HEM402 4.3 40.5 1.0 CG C:HIS97 4.3 22.2 1.0 ND1 C:HIS97 4.3 27.2 1.0

Iron binding site 3 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe303 b:44.1 occ:1.00 FE D:HEC303 0.0 44.1 1.0 NE2 D:HIS41 1.9 35.3 1.0 NC D:HEC303 2.0 50.8 1.0 NA D:HEC303 2.0 45.2 1.0 ND D:HEC303 2.0 45.4 1.0 NB D:HEC303 2.1 44.8 1.0 SD D:MET160 2.2 40.4 1.0 CE1 D:HIS41 2.8 33.8 1.0 CD2 D:HIS41 3.0 37.2 1.0 C4C D:HEC303 3.0 50.6 1.0 C1A D:HEC303 3.0 47.5 1.0 C4D D:HEC303 3.0 40.4 1.0 C1D D:HEC303 3.1 45.0 1.0 C1C D:HEC303 3.1 57.4 1.0 C4A D:HEC303 3.1 44.5 1.0 C4B D:HEC303 3.1 47.7 1.0 C1B D:HEC303 3.1 47.7 1.0 CHA D:HEC303 3.4 47.0 1.0 CHD D:HEC303 3.4 43.7 1.0 CHC D:HEC303 3.4 54.1 1.0 CHB D:HEC303 3.5 50.5 1.0 CG D:MET160 3.5 39.2 1.0 CE D:MET160 3.7 37.0 1.0 ND1 D:HIS41 3.9 32.8 1.0 CG D:HIS41 4.0 36.0 1.0 C3C D:HEC303 4.3 61.6 1.0 C2A D:HEC303 4.3 45.4 1.0 C3A D:HEC303 4.3 43.5 1.0 C2C D:HEC303 4.3 68.0 1.0 C3D D:HEC303 4.3 39.8 1.0 C2D D:HEC303 4.3 43.2 1.0 C3B D:HEC303 4.3 47.5 1.0 C2B D:HEC303 4.3 45.7 1.0 CB D:MET160 4.4 47.8 1.0

Iron binding site 4 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe201 b:290.7 occ:1.00 FE1 E:FES201 0.0 290.7 1.0 S1 E:FES201 2.2 320.0 1.0 S2 E:FES201 2.2 323.6 1.0 SG E:CYS139 2.3 249.8 1.0 SG E:CYS158 2.3 231.3 1.0 FE2 E:FES201 2.7 353.9 1.0 CB E:CYS158 3.6 223.3 1.0 CB E:CYS139 3.8 212.5 1.0 OG E:SER163 4.4 165.1 1.0 CB E:HIS161 4.4 191.1 1.0 CB E:HIS141 4.5 215.3 1.0 N E:HIS161 4.6 186.2 1.0 CB E:CYS160 4.7 219.9 1.0 N E:LEU142 4.8 200.0 1.0 CB E:CYS144 4.8 211.8 1.0 CB E:SER163 4.9 167.8 1.0 CA E:CYS158 5.0 229.5 1.0

Iron binding site 5 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe201 b:353.9 occ:1.00 FE2 E:FES201 0.0 353.9 1.0 S1 E:FES201 2.2 320.0 1.0 S2 E:FES201 2.2 323.6 1.0 FE1 E:FES201 2.7 290.7 1.0 ND1 E:HIS141 3.2 220.7 1.0 CB E:HIS161 3.2 191.1 1.0 ND1 E:HIS161 3.4 205.3 1.0 CG E:PRO175 3.4 191.0 1.0 CB E:HIS141 3.7 215.3 1.0 CG E:HIS161 3.7 203.0 1.0 CG E:HIS141 3.8 222.1 1.0 CD E:PRO175 4.0 184.1 1.0 CE1 E:HIS141 4.3 216.2 1.0 SG E:CYS139 4.4 249.8 1.0 CA E:HIS161 4.5 181.0 1.0 OG E:SER163 4.6 165.1 1.0 CE1 E:HIS161 4.6 202.3 1.0 SG E:CYS158 4.7 231.3 1.0 N E:HIS161 4.7 186.2 1.0 CB E:PRO175 4.8 195.7 1.0 N E:LEU142 4.9 200.0 1.0 CB E:LEU142 5.0 176.0 1.0

Iron binding site 6 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ N:Fe401 b:25.4 occ:1.00 FE N:HEM401 0.0 25.4 1.0 NA N:HEM401 2.0 34.0 1.0 NC N:HEM401 2.0 33.6 1.0 ND N:HEM401 2.0 26.0 1.0 NB N:HEM401 2.0 32.8 1.0 NE2 N:HIS182 2.0 15.3 1.0 NE2 N:HIS83 2.0 24.2 1.0 CE1 N:HIS182 2.7 16.0 1.0 CE1 N:HIS83 2.9 22.8 1.0 C1A N:HEM401 3.0 35.5 1.0 C4D N:HEM401 3.0 23.4 1.0 C1D N:HEM401 3.0 29.5 1.0 C4C N:HEM401 3.0 32.0 1.0 C1B N:HEM401 3.0 34.4 1.0 C4B N:HEM401 3.0 35.9 1.0 C4A N:HEM401 3.0 35.9 1.0 C1C N:HEM401 3.1 34.9 1.0 CD2 N:HIS83 3.1 29.0 1.0 CD2 N:HIS182 3.3 12.3 1.0 CHA N:HEM401 3.4 28.0 1.0 CHD N:HEM401 3.4 31.5 1.0 CHB N:HEM401 3.4 32.4 1.0 CHC N:HEM401 3.5 34.1 1.0 ND1 N:HIS182 3.9 16.4 1.0 ND1 N:HIS83 4.1 22.6 1.0 C2A N:HEM401 4.2 37.0 1.0 CG N:HIS83 4.2 25.6 1.0 C3C N:HEM401 4.2 39.5 1.0 C3A N:HEM401 4.2 37.2 1.0 C2B N:HEM401 4.2 35.2 1.0 C2C N:HEM401 4.2 36.3 1.0 CG N:HIS182 4.2 12.9 1.0 C3D N:HEM401 4.2 31.6 1.0 C2D N:HEM401 4.2 29.6 1.0 C3B N:HEM401 4.3 41.4 1.0 OE1 N:GLN44 4.7 51.3 1.0 CA N:GLY130 4.9 36.8 1.0

Iron binding site 7 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ N:Fe402 b:32.5 occ:1.00 FE N:HEM402 0.0 32.5 1.0 NC N:HEM402 2.0 32.1 1.0 NA N:HEM402 2.0 35.8 1.0 ND N:HEM402 2.0 31.7 1.0 NB N:HEM402 2.0 43.8 1.0 NE2 N:HIS196 2.2 47.6 1.0 NE2 N:HIS97 2.2 32.2 1.0 CE1 N:HIS196 3.0 49.4 1.0 C4D N:HEM402 3.0 30.3 1.0 C4C N:HEM402 3.0 32.6 1.0 C1D N:HEM402 3.0 33.1 1.0 C1A N:HEM402 3.0 33.5 1.0 C1B N:HEM402 3.0 41.9 1.0 C4B N:HEM402 3.0 44.6 1.0 CE1 N:HIS97 3.0 29.5 1.0 C4A N:HEM402 3.0 36.0 1.0 C1C N:HEM402 3.0 33.5 1.0 CD2 N:HIS196 3.3 52.1 1.0 CD2 N:HIS97 3.3 34.5 1.0 CHA N:HEM402 3.4 31.8 1.0 CHD N:HEM402 3.4 33.1 1.0 CHB N:HEM402 3.4 38.0 1.0 CHC N:HEM402 3.4 39.0 1.0 ND1 N:HIS196 4.1 50.5 1.0 C2A N:HEM402 4.2 36.2 1.0 C3C N:HEM402 4.2 36.1 1.0 ND1 N:HIS97 4.2 31.1 1.0 C2C N:HEM402 4.2 34.1 1.0 C3A N:HEM402 4.2 33.8 1.0 C2B N:HEM402 4.2 40.8 1.0 C3D N:HEM402 4.2 31.5 1.0 C2D N:HEM402 4.2 29.9 1.0 C3B N:HEM402 4.3 46.3 1.0 CG N:HIS196 4.3 49.2 1.0 CG N:HIS97 4.4 30.2 1.0

Iron binding site 8 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ O:Fe303 b:32.2 occ:1.00 FE O:HEC303 0.0 32.2 1.0 NC O:HEC303 2.0 51.0 1.0 NE2 O:HIS41 2.0 35.0 1.0 NB O:HEC303 2.0 45.5 1.0 NA O:HEC303 2.1 51.9 1.0 ND O:HEC303 2.1 49.5 1.0 SD O:MET160 2.3 48.3 1.0 CE1 O:HIS41 2.9 40.0 1.0 C4C O:HEC303 3.0 51.7 1.0 C1C O:HEC303 3.0 57.2 1.0 CD2 O:HIS41 3.0 35.7 1.0 C1D O:HEC303 3.0 48.2 1.0 C4B O:HEC303 3.1 52.7 1.0 C1B O:HEC303 3.1 45.8 1.0 C4A O:HEC303 3.1 53.7 1.0 C1A O:HEC303 3.1 53.2 1.0 C4D O:HEC303 3.1 51.4 1.0 CHD O:HEC303 3.4 48.9 1.0 CHC O:HEC303 3.4 52.6 1.0 CHB O:HEC303 3.4 48.5 1.0 CHA O:HEC303 3.5 51.1 1.0 CE O:MET160 3.5 66.6 1.0 CG O:MET160 3.6 42.5 1.0 ND1 O:HIS41 4.1 41.3 1.0 CG O:HIS41 4.1 38.8 1.0 C3C O:HEC303 4.2 57.9 1.0 C2C O:HEC303 4.2 61.8 1.0 C3B O:HEC303 4.3 52.4 1.0 C2B O:HEC303 4.3 48.1 1.0 C2D O:HEC303 4.3 46.1 1.0 C3A O:HEC303 4.3 55.7 1.0 C2A O:HEC303 4.3 57.0 1.0 C3D O:HEC303 4.3 47.6 1.0 CB O:MET160 4.4 46.1 1.0

Iron binding site 9 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe201 b:330.7 occ:1.00 FE1 P:FES201 0.0 330.7 1.0 S1 P:FES201 2.2 353.8 1.0 S2 P:FES201 2.2 350.6 1.0 SG P:CYS139 2.3 268.7 1.0 SG P:CYS158 2.3 249.1 1.0 CB P:CYS139 2.6 216.6 1.0 FE2 P:FES201 2.7 351.4 1.0 CD2 P:HIS161 3.0 325.9 1.0 NE2 P:HIS161 3.4 329.5 1.0 CB P:CYS158 3.6 234.1 1.0 CG P:HIS161 3.7 305.6 1.0 CA P:CYS139 4.0 193.4 1.0 CE1 P:HIS161 4.3 327.0 1.0 ND1 P:HIS161 4.4 323.2 1.0 CB P:HIS161 4.4 232.6 1.0 OG P:SER163 4.5 167.4 1.0 N P:THR140 4.5 197.0 1.0 OH P:TYR165 4.5 200.5 1.0 O P:CYS144 4.6 187.0 1.0 C P:CYS139 4.8 195.9 1.0 ND1 P:HIS141 4.8 257.6 1.0 CB P:SER163 4.8 171.2 1.0 CB P:CYS144 4.9 207.5 1.0 CE1 P:TYR165 4.9 202.1 1.0 N P:CYS139 5.0 190.7 1.0

Iron binding site 10 out of 12 in the Murine Supercomplex CIII2CIV in the Assembled Locked Conformation


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Murine Supercomplex CIII2CIV in the Assembled Locked Conformation within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe201 b:351.4 occ:1.00 FE2 P:FES201 0.0 351.4 1.0 CE1 P:HIS161 2.1 327.0 1.0 NE2 P:HIS161 2.1 329.5 1.0 S1 P:FES201 2.2 353.8 1.0 S2 P:FES201 2.2 350.6 1.0 ND1 P:HIS161 2.3 323.2 1.0 ND1 P:HIS141 2.3 257.6 1.0 CD2 P:HIS161 2.4 325.9 1.0 CG P:HIS161 2.5 305.6 1.0 FE1 P:FES201 2.7 330.7 1.0 CE1 P:HIS141 3.1 250.2 1.0 CG P:HIS141 3.5 246.2 1.0 CB P:HIS161 3.6 232.6 1.0 CB P:HIS141 3.9 226.5 1.0 N P:HIS141 4.0 211.4 1.0 NE2 P:HIS141 4.3 246.0 1.0 CB P:CYS139 4.3 216.6 1.0 CD2 P:HIS141 4.5 245.9 1.0 N P:THR140 4.5 197.0 1.0 SG P:CYS158 4.6 249.1 1.0 CG P:PRO175 4.6 188.3 1.0 CA P:HIS141 4.6 213.8 1.0 SG P:CYS139 4.8 268.7 1.0 OG P:SER163 4.8 167.4 1.0 CA P:HIS161 5.0 192.1 1.0

I.Vercellino, L.A.Sazanov. Structure and Assembly of the Mammalian Mitochondrial Supercomplex CIII2CIV Nature 2021.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-021-03927-Z