Iron in PDB 7o4l: Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex

All present enzymatic activity of Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex:
2.7.7.6; 3.6.4.12;

The structure of Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex also contains other interesting chemical elements:

Fluorine	(F)	3 atoms
Magnesium	(Mg)	1 atom
Zinc	(Zn)	11 atoms

The binding sites of Iron atom in the Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex (pdb code 7o4l). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex, PDB code: 7o4l:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:60.8 occ:1.00 FE1 0:SF4801 0.0 60.8 1.0 SG 0:CYS115 2.3 63.3 1.0 S2 0:SF4801 2.3 60.8 1.0 S3 0:SF4801 2.3 60.8 1.0 S4 0:SF4801 2.3 60.8 1.0 FE4 0:SF4801 2.7 60.8 1.0 FE3 0:SF4801 2.7 60.8 1.0 FE2 0:SF4801 2.7 60.8 1.0 CB 0:CYS115 3.3 63.3 1.0 CA 0:CYS115 3.6 63.3 1.0 S1 0:SF4801 3.9 60.8 1.0 N 0:LEU116 3.9 65.4 1.0 CB 0:HIS117 4.0 71.1 1.0 N 0:HIS117 4.0 71.1 1.0 C 0:CYS115 4.2 63.3 1.0 CA 0:HIS117 4.7 71.1 1.0 CG1 0:VAL120 4.7 70.3 1.0 CB 0:CYS133 4.8 69.8 1.0 SG 0:CYS133 4.8 69.8 1.0 CB 0:VAL120 4.8 70.3 1.0 SG 0:CYS156 4.8 77.0 1.0 N 0:CYS115 4.9 63.3 1.0 SG 0:CYS191 4.9 64.3 1.0

Iron binding site 2 out of 4 in the Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:60.8 occ:1.00 FE2 0:SF4801 0.0 60.8 1.0 SG 0:CYS156 2.3 77.0 1.0 S1 0:SF4801 2.3 60.8 1.0 S3 0:SF4801 2.3 60.8 1.0 S4 0:SF4801 2.3 60.8 1.0 FE4 0:SF4801 2.7 60.8 1.0 FE1 0:SF4801 2.7 60.8 1.0 FE3 0:SF4801 2.7 60.8 1.0 CB 0:CYS156 3.6 77.0 1.0 S2 0:SF4801 3.9 60.8 1.0 CB 0:HIS117 4.2 71.1 1.0 CB 0:TYR158 4.6 69.1 1.0 SG 0:CYS191 4.7 64.3 1.0 CD2 0:HIS117 4.7 71.1 1.0 SG 0:CYS115 4.8 63.3 1.0 CG 0:HIS117 4.8 71.1 1.0 SG 0:CYS133 4.8 69.8 1.0 CA 0:CYS156 4.9 77.0 1.0 N 0:HIS159 4.9 71.8 1.0 N 0:HIS117 4.9 71.1 1.0

Iron binding site 3 out of 4 in the Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:60.8 occ:1.00 FE3 0:SF4801 0.0 60.8 1.0 SG 0:CYS133 2.3 69.8 1.0 S1 0:SF4801 2.3 60.8 1.0 S4 0:SF4801 2.3 60.8 1.0 S2 0:SF4801 2.3 60.8 1.0 FE4 0:SF4801 2.7 60.8 1.0 FE1 0:SF4801 2.7 60.8 1.0 FE2 0:SF4801 2.7 60.8 1.0 CB 0:CYS133 3.0 69.8 1.0 CA 0:CYS133 3.8 69.8 1.0 S3 0:SF4801 3.9 60.8 1.0 C 0:CYS133 4.5 69.8 1.0 O 0:CYS133 4.5 69.8 1.0 CE2 0:PHE194 4.6 60.9 1.0 SG 0:CYS191 4.7 64.3 1.0 SG 0:CYS115 4.7 63.3 1.0 CD 0:ARG111 4.7 61.4 1.0 NE 0:ARG111 4.8 61.4 1.0 CG2 0:THR137 4.8 75.6 1.0 SG 0:CYS156 4.8 77.0 1.0 N 0:CYS133 5.0 69.8 1.0

Iron binding site 4 out of 4 in the Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Yeast Tfiih in the Expanded State Within the Pre-Initiation Complex within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:60.8 occ:1.00 FE4 0:SF4801 0.0 60.8 1.0 SG 0:CYS191 2.3 64.3 1.0 S1 0:SF4801 2.3 60.8 1.0 S2 0:SF4801 2.3 60.8 1.0 S3 0:SF4801 2.3 60.8 1.0 FE3 0:SF4801 2.7 60.8 1.0 FE2 0:SF4801 2.7 60.8 1.0 FE1 0:SF4801 2.7 60.8 1.0 CB 0:CYS191 3.3 64.3 1.0 S4 0:SF4801 3.9 60.8 1.0 CA 0:CYS191 4.3 64.3 1.0 CD2 0:PHE194 4.5 60.9 1.0 SG 0:CYS133 4.6 69.8 1.0 SG 0:CYS156 4.7 77.0 1.0 CA 0:CYS115 4.7 63.3 1.0 CE2 0:PHE194 4.8 60.9 1.0 SG 0:CYS115 4.8 63.3 1.0 CB 0:TYR193 4.8 58.0 1.0 N 0:LEU116 5.0 65.4 1.0

S.Schilbach, S.Aibara, C.Dienemann, F.Grabbe, P.Cramer. Structure of Rna Polymerase II Pre-Initiation Complex at 2.9 Angstrom Defines Initial Dna Opening Cell(Cambridge,Mass.) 2021.
ISSN: ISSN 0092-8674
DOI: 10.1016/J.CELL.2021.05.012