Iron in PDB 7o66: Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site

Enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site

All present enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site:
1.16.3.1;

Protein crystallography data

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site, PDB code: 7o66 was solved by C.Pozzi, S.Ciambellotti, G.Tassone, P.Turano, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 64.99 / 1.60
Space group F 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 183.83, 183.83, 183.83, 90, 90, 90
R / Rfree (%) 15.5 / 17.9

Other elements in 7o66:

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site also contains other interesting chemical elements:

Chlorine (Cl) 6 atoms
Magnesium (Mg) 1 atom

Iron Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 11;

Binding sites:

The binding sites of Iron atom in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site (pdb code 7o66). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 11 binding sites of Iron where determined in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site, PDB code: 7o66:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 11 in 7o66

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Iron binding site 1 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe202

b:22.5
occ:0.25
NE2 A:HIS173 2.1 19.1 0.4
O A:HOH467 2.3 20.1 0.2
NE2 A:HIS173 2.3 19.3 0.6
CL A:CL213 2.4 23.9 0.2
CE1 A:HIS173 3.0 20.0 0.4
CD2 A:HIS173 3.2 20.4 0.4
CE1 A:HIS173 3.2 21.9 0.6
CD2 A:HIS173 3.4 21.3 0.6
ND1 A:HIS173 4.2 20.4 0.4
CG A:HIS173 4.3 20.3 0.4
ND1 A:HIS173 4.4 20.9 0.6
CG A:HIS173 4.5 21.0 0.6
O A:HOH476 4.7 46.3 1.0

Iron binding site 2 out of 11 in 7o66

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Iron binding site 2 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe203

b:24.1
occ:0.90
OE2 A:GLU27 2.0 21.9 1.0
OE1 A:GLU62 2.1 24.1 1.0
O A:HOH326 2.1 26.6 0.7
O A:HOH369 2.1 23.0 0.8
ND1 A:HIS65 2.2 24.3 0.9
O1 A:OXY201 2.8 21.9 0.7
CD A:GLU62 3.0 24.8 1.0
CE1 A:HIS65 3.1 25.2 0.9
CD A:GLU27 3.1 23.3 1.0
CG A:HIS65 3.3 23.1 0.9
OE2 A:GLU62 3.4 27.7 1.0
FE A:FE2204 3.4 22.5 0.7
OE1 A:GLU27 3.5 22.6 1.0
CB A:HIS65 3.7 18.6 1.0
O2 A:OXY201 3.9 25.9 0.7
O A:HOH480 4.0 42.4 1.0
OE1 A:GLN141 4.0 28.6 1.0
NE2 A:HIS65 4.3 25.4 0.9
CG1 A:VAL110 4.4 21.9 1.0
CG A:GLU62 4.4 19.4 1.0
CG A:GLU27 4.4 21.2 1.0
CD2 A:HIS65 4.4 24.3 0.9
CA A:GLU62 4.5 17.9 1.0
O A:HOH417 4.5 23.4 0.3
CB A:GLU62 4.7 16.6 1.0
CB A:GLU27 4.8 17.8 1.0
O A:HOH478 4.8 34.3 0.7
O A:HOH417 4.8 28.7 0.7
CD A:GLN141 4.9 28.7 1.0
NE2 A:GLN141 4.9 29.7 1.0

Iron binding site 3 out of 11 in 7o66

Go back to Iron Binding Sites List in 7o66
Iron binding site 3 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe204

b:22.5
occ:0.70
O A:HOH326 1.8 26.6 0.7
OE2 A:GLU62 1.9 27.7 1.0
OE2 A:GLU107 2.1 29.3 1.0
OE1 A:GLU107 2.2 26.4 1.0
O A:HOH417 2.2 28.7 0.7
O1 A:OXY201 2.4 21.9 0.7
O2 A:OXY201 2.4 25.9 0.7
CD A:GLU107 2.4 24.8 1.0
O A:HOH417 2.6 23.4 0.3
CD A:GLU62 3.0 24.8 1.0
OE1 A:GLU62 3.4 24.1 1.0
FE A:FE2203 3.4 24.1 0.9
O A:HOH431 3.8 34.1 1.0
NE2 A:GLN141 3.9 29.7 1.0
CG A:GLU107 3.9 20.1 1.0
OE1 A:GLN141 4.0 28.6 1.0
O A:HOH478 4.2 34.3 0.7
CG A:GLU62 4.3 19.4 1.0
CD A:GLN141 4.3 28.7 1.0
CE2 A:TYR34 4.4 21.6 1.0
CE1 A:HIS65 4.4 25.2 0.9
OG A:SER144 4.5 20.6 0.4
OH A:TYR34 4.5 29.3 1.0
ND1 A:HIS65 4.6 24.3 0.9
O A:HOH369 4.7 23.0 0.8
CB A:GLU107 4.8 17.9 1.0
CA A:GLU107 4.9 17.0 1.0
CZ A:TYR34 4.9 27.2 1.0

Iron binding site 4 out of 11 in 7o66

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Iron binding site 4 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe205

b:23.3
occ:0.25
O A:HOH381 2.0 25.5 1.0
O A:HOH305 2.1 34.3 1.0
OD1 A:ASP131 3.6 29.6 1.0
FE A:FE2212 3.8 38.2 0.1
O A:HOH555 3.8 35.9 0.3
OG1 A:THR135 4.2 24.3 1.0
OE1 A:GLU134 4.3 26.4 1.0
CG A:ASP131 4.8 33.4 1.0
CB A:GLU134 4.9 21.0 1.0

Iron binding site 5 out of 11 in 7o66

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Iron binding site 5 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe206

b:22.0
occ:0.30
O A:HOH338 2.0 18.9 0.5
O A:HOH345 2.1 19.3 1.0
OD2 A:ASP84 4.0 16.4 1.0
OD1 A:ASP84 4.2 14.9 1.0
CG A:ASP84 4.5 15.0 1.0
O A:HOH408 4.7 15.6 1.0

Iron binding site 6 out of 11 in 7o66

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Iron binding site 6 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe207

b:24.6
occ:0.20
O A:HOH361 2.1 28.0 1.0
O A:HOH498 2.2 34.2 1.0
FE A:FE2212 3.2 38.2 0.1
OE2 A:GLU134 3.8 25.1 1.0
O A:HOH570 4.2 29.4 1.0
O A:HOH447 4.2 44.2 1.0
OE1 A:GLU134 4.2 26.4 1.0
CD A:GLU134 4.5 25.3 1.0

Iron binding site 7 out of 11 in 7o66

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Iron binding site 7 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe208

b:44.7
occ:0.35
FE A:FE2208 0.0 44.7 0.3
OE1 A:GLU61 2.1 36.1 0.7
OE1 A:GLU64 2.2 34.3 0.7
O A:HOH504 2.3 48.1 0.6
O A:HOH487 2.4 53.4 1.0
O A:HOH437 2.4 56.0 0.8
OE2 A:GLU61 2.7 37.7 0.7
FE A:FE2208 2.7 43.3 0.2
CD A:GLU61 2.7 33.7 0.7
CD A:GLU64 3.3 32.8 0.7
OE2 A:GLU64 3.8 37.1 0.7
O A:HOH512 3.8 42.6 0.8
O A:HOH350 3.9 37.2 0.5
OE2 A:GLU61 4.0 26.7 0.3
FE A:FE2210 4.2 51.5 0.3
CG A:GLU61 4.2 29.0 0.7
CG A:GLU61 4.5 23.0 0.3
O A:HOH373 4.5 51.8 1.0
CG A:GLU64 4.6 29.6 1.0
CD A:GLU61 4.7 24.9 0.3
CB A:GLU64 4.7 21.6 1.0
CB A:GLU61 4.9 23.1 0.7
O A:HOH530 4.9 42.2 1.0
CA A:GLU61 4.9 20.0 0.7
CB A:GLU61 4.9 20.6 0.3
CA A:GLU61 4.9 19.1 0.3

Iron binding site 8 out of 11 in 7o66

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Iron binding site 8 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe208

b:43.3
occ:0.25
FE A:FE2208 0.0 43.3 0.2
OE2 A:GLU61 1.9 37.7 0.7
OE2 A:GLU64 2.2 37.1 0.7
O A:HOH373 2.4 51.8 1.0
O A:HOH437 2.5 56.0 0.8
OE1 A:GLU64 2.6 34.3 0.7
CD A:GLU64 2.7 32.8 0.7
FE A:FE2208 2.7 44.7 0.3
O A:HOH512 2.7 42.6 0.8
CD A:GLU61 3.0 33.7 0.7
OE1 A:GLU61 3.5 36.1 0.7
FE A:FE2210 4.0 51.5 0.3
CG A:GLU64 4.1 29.6 1.0
O A:HOH487 4.1 53.4 1.0
CG A:GLU61 4.2 29.0 0.7
CG A:GLU61 4.4 23.0 0.3
O A:HOH504 4.5 48.1 0.6
CE1 A:HIS57 4.5 33.2 1.0
OE2 A:GLU61 4.8 26.7 0.3
CA A:GLU61 4.8 20.0 0.7
CA A:GLU61 4.8 19.1 0.3

Iron binding site 9 out of 11 in 7o66

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Iron binding site 9 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe209

b:33.6
occ:0.30
OE1 A:GLU61 1.9 27.5 0.3
O A:HOH455 2.2 45.8 1.0
OE1 A:GLN58 2.3 29.5 0.8
O A:HOH362 2.9 39.7 0.8
CD A:GLU61 3.0 24.9 0.3
CD A:GLN58 3.2 26.6 0.8
NE2 A:GLN58 3.3 31.9 0.8
OE2 A:GLU61 3.5 26.7 0.3
O A:HOH481 3.7 41.7 0.5
O A:HOH431 3.9 34.1 1.0
O A:HOH509 4.1 35.9 0.5
O A:HOH434 4.1 41.0 1.0
CG A:GLU61 4.2 23.0 0.3
OG A:SER144 4.3 20.6 0.6
CG A:GLU61 4.3 29.0 0.7
CD2 A:HIS57 4.4 31.9 1.0
OE1 A:GLU147 4.6 24.6 0.7
NE2 A:HIS57 4.6 34.8 1.0
CG A:GLN58 4.6 22.5 1.0
O A:HOH442 4.7 31.5 1.0
O A:HOH417 4.7 28.7 0.7
CB A:GLU61 4.7 20.6 0.3
CB A:GLU61 4.8 23.1 0.7
CA A:GLN58 4.9 17.8 1.0

Iron binding site 10 out of 11 in 7o66

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Iron binding site 10 out of 11 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 60 Minutes Showing Either A Dioxygen or A Superoxide Anion Coordinated to Iron Ions in the Ferroxidase Site within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe210

b:51.5
occ:0.30
O A:HOH514 2.3 22.9 0.2
NE2 A:HIS57 2.6 34.8 1.0
CE1 A:HIS57 2.7 33.2 1.0
OE2 A:GLU61 2.9 26.7 0.3
O A:HOH512 3.0 42.6 0.8
OE2 A:GLU61 3.1 37.7 0.7
O A:HOH487 3.2 53.4 1.0
CD A:GLU61 3.5 33.7 0.7
CD A:GLU61 3.7 24.9 0.3
CD2 A:HIS57 4.0 31.9 1.0
OE1 A:GLU61 4.0 36.1 0.7
FE A:FE2208 4.0 43.3 0.2
ND1 A:HIS57 4.1 33.1 1.0
CG A:GLU61 4.1 29.0 0.7
FE A:FE2208 4.2 44.7 0.3
CG A:GLU61 4.2 23.0 0.3
OE1 A:GLU61 4.7 27.5 0.3
CG A:HIS57 4.7 29.5 1.0
O A:HOH437 4.9 56.0 0.8

Reference:

S.Ciambellotti, A.Pratesi, G.Tassone, P.Turano, S.Mangani, C.Pozzi. Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34343376
DOI: 10.1002/CHEM.202102270
Page generated: Fri Nov 5 14:03:54 2021

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