Iron in PDB 7opl: Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1

All present enzymatic activity of Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1:
2.7.7.7;

The structure of Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1 also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

The binding sites of Iron atom in the Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1 (pdb code 7opl). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1, PDB code: 7opl:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe601 b:122.3 occ:1.00 FE1 D:SF4601 0.0 122.3 1.0 SG D:CYS367 2.3 94.2 1.0 S4 D:SF4601 2.3 122.3 1.0 S2 D:SF4601 2.3 122.3 1.0 S3 D:SF4601 2.3 122.3 1.0 CB D:CYS367 2.6 94.2 1.0 FE3 D:SF4601 2.7 122.3 1.0 FE2 D:SF4601 2.7 122.3 1.0 FE4 D:SF4601 2.7 122.3 1.0 CA D:CYS367 3.7 94.2 1.0 S1 D:SF4601 3.9 122.3 1.0 CD1 D:LEU441 4.4 101.3 1.0 CD1 D:ILE371 4.4 81.2 1.0 C D:CYS367 4.5 94.2 1.0 O D:CYS367 4.5 94.2 1.0 OE1 D:GLN421 4.6 102.7 1.0 N D:CYS367 4.9 94.2 1.0 SG D:CYS424 4.9 114.4 1.0 SG D:CYS384 4.9 100.0 1.0 CB D:CYS384 5.0 100.0 1.0 SG D:CYS287 5.0 111.1 1.0

Iron binding site 2 out of 4 in the Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe601 b:122.3 occ:1.00 FE2 D:SF4601 0.0 122.3 1.0 SG D:CYS384 2.3 100.0 1.0 S1 D:SF4601 2.3 122.3 1.0 S3 D:SF4601 2.3 122.3 1.0 S4 D:SF4601 2.3 122.3 1.0 FE4 D:SF4601 2.7 122.3 1.0 FE3 D:SF4601 2.7 122.3 1.0 FE1 D:SF4601 2.7 122.3 1.0 CB D:CYS384 2.9 100.0 1.0 CA D:CYS384 3.9 100.0 1.0 S2 D:SF4601 3.9 122.3 1.0 CD1 D:ILE371 4.3 81.2 1.0 SG D:CYS287 4.5 111.1 1.0 CG1 D:ILE371 4.5 81.2 1.0 SG D:CYS424 4.7 114.4 1.0 CD D:PRO385 4.7 95.6 1.0 CB D:CYS424 4.7 114.4 1.0 C D:CYS384 4.8 100.0 1.0 SG D:CYS367 4.9 94.2 1.0 N D:CYS384 5.0 100.0 1.0 CD2 D:PHE386 5.0 98.4 1.0

Iron binding site 3 out of 4 in the Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe601 b:122.3 occ:1.00 FE3 D:SF4601 0.0 122.3 1.0 SG D:CYS424 2.3 114.4 1.0 S1 D:SF4601 2.3 122.3 1.0 S2 D:SF4601 2.3 122.3 1.0 S4 D:SF4601 2.3 122.3 1.0 FE4 D:SF4601 2.7 122.3 1.0 FE1 D:SF4601 2.7 122.3 1.0 FE2 D:SF4601 2.7 122.3 1.0 CB D:CYS424 3.0 114.4 1.0 S3 D:SF4601 3.9 122.3 1.0 CD1 D:LEU441 4.1 101.3 1.0 CB D:PRO285 4.3 101.0 1.0 SG D:CYS367 4.4 94.2 1.0 CA D:CYS424 4.5 114.4 1.0 SG D:CYS287 4.6 111.1 1.0 SG D:CYS384 4.8 100.0 1.0 CD D:PRO286 4.8 109.9 1.0

Iron binding site 4 out of 4 in the Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryoem Structure of Dna Polymerase Alpha - Primase Bound to Sars Cov NSP1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe601 b:122.3 occ:1.00 FE4 D:SF4601 0.0 122.3 1.0 SG D:CYS287 2.3 111.1 1.0 S1 D:SF4601 2.3 122.3 1.0 S3 D:SF4601 2.3 122.3 1.0 S2 D:SF4601 2.3 122.3 1.0 FE2 D:SF4601 2.7 122.3 1.0 FE3 D:SF4601 2.7 122.3 1.0 FE1 D:SF4601 2.7 122.3 1.0 CB D:CYS287 3.7 111.1 1.0 S4 D:SF4601 3.9 122.3 1.0 SG D:CYS367 4.0 94.2 1.0 CB D:PRO285 4.3 101.0 1.0 CB D:CYS384 4.5 100.0 1.0 CG D:PRO285 4.6 101.0 1.0 SG D:CYS384 4.6 100.0 1.0 N D:CYS287 4.6 111.1 1.0 SG D:CYS424 4.7 114.4 1.0 CG D:PRO444 4.7 93.1 1.0 CA D:CYS384 4.8 100.0 1.0 CA D:CYS287 4.8 111.1 1.0 CD1 D:ILE370 4.9 85.8 1.0 CG2 D:ILE370 5.0 85.8 1.0

M.L.Kilkenny, C.E.Veale, A.Guppy, S.W.Hardwick, D.Y.Chirgadze, N.J.Rzechorzek, J.D.Maman, L.Pellegrini. Structural Basis For the Interaction of Sars-Cov-2 Virulence Factor NSP1 with Dna Polymerase A - Primase. Protein Sci. 2021.
ISSN: ESSN 1469-896X
PubMed: 34719824
DOI: 10.1002/PRO.4220