Iron in PDB 7p0o: Mitoneet Bound to M1 Molecule
Protein crystallography data
The structure of Mitoneet Bound to M1 Molecule, PDB code: 7p0o
was solved by
O.Livnah,
Y.Eisenberg-Domovich,
H.B.Marjault,
R.Nechushtai,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
38.11 /
1.65
|
Space group
|
P 21 21 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
45.152,
49.962,
58.945,
90,
90,
90
|
R / Rfree (%)
|
17.1 /
23.6
|
Iron Binding Sites:
The binding sites of Iron atom in the Mitoneet Bound to M1 Molecule
(pdb code 7p0o). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the
Mitoneet Bound to M1 Molecule, PDB code: 7p0o:
Jump to Iron binding site number:
1;
2;
3;
4;
Iron binding site 1 out
of 4 in 7p0o
Go back to
Iron Binding Sites List in 7p0o
Iron binding site 1 out
of 4 in the Mitoneet Bound to M1 Molecule
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Mitoneet Bound to M1 Molecule within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe200
b:27.2
occ:1.00
|
FE1
|
A:FES200
|
0.0
|
27.2
|
1.0
|
SG
|
A:CYS74
|
2.2
|
25.9
|
1.0
|
S1
|
A:FES200
|
2.2
|
29.7
|
1.0
|
S2
|
A:FES200
|
2.3
|
27.2
|
1.0
|
SG
|
A:CYS72
|
2.4
|
25.3
|
1.0
|
FE2
|
A:FES200
|
2.7
|
28.1
|
1.0
|
CB
|
A:CYS74
|
3.3
|
26.8
|
1.0
|
CB
|
A:CYS72
|
3.4
|
25.0
|
1.0
|
N
|
A:CYS74
|
3.5
|
24.4
|
1.0
|
CA
|
A:CYS72
|
3.8
|
24.9
|
1.0
|
CA
|
A:CYS74
|
3.9
|
27.5
|
1.0
|
N
|
A:ARG73
|
3.9
|
22.0
|
1.0
|
ND1
|
A:HIS87
|
4.1
|
29.9
|
1.0
|
CB
|
A:HIS87
|
4.1
|
30.3
|
1.0
|
N
|
A:HIS87
|
4.2
|
31.0
|
1.0
|
C
|
A:CYS72
|
4.2
|
25.5
|
1.0
|
N
|
A:TRP75
|
4.4
|
24.4
|
1.0
|
N
|
A:SER77
|
4.4
|
30.6
|
1.0
|
C
|
A:CYS74
|
4.4
|
24.1
|
1.0
|
CB
|
A:SER77
|
4.5
|
29.6
|
1.0
|
CG
|
A:HIS87
|
4.6
|
26.3
|
1.0
|
N
|
A:ARG76
|
4.6
|
25.7
|
1.0
|
CA
|
A:HIS87
|
4.6
|
34.2
|
1.0
|
C
|
A:ARG73
|
4.6
|
25.5
|
1.0
|
SG
|
A:CYS83
|
4.6
|
29.3
|
1.0
|
CA
|
A:CYS83
|
4.9
|
31.1
|
1.0
|
CB
|
A:CYS83
|
4.9
|
29.8
|
1.0
|
CA
|
A:ARG73
|
4.9
|
23.5
|
1.0
|
CA
|
A:SER77
|
4.9
|
31.0
|
1.0
|
|
Iron binding site 2 out
of 4 in 7p0o
Go back to
Iron Binding Sites List in 7p0o
Iron binding site 2 out
of 4 in the Mitoneet Bound to M1 Molecule
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Mitoneet Bound to M1 Molecule within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe200
b:28.1
occ:1.00
|
FE2
|
A:FES200
|
0.0
|
28.1
|
1.0
|
ND1
|
A:HIS87
|
2.1
|
29.9
|
1.0
|
S2
|
A:FES200
|
2.2
|
27.2
|
1.0
|
SG
|
A:CYS83
|
2.2
|
29.3
|
1.0
|
S1
|
A:FES200
|
2.3
|
29.7
|
1.0
|
FE1
|
A:FES200
|
2.7
|
27.2
|
1.0
|
CE1
|
A:HIS87
|
2.8
|
34.5
|
1.0
|
CG
|
A:HIS87
|
3.2
|
26.3
|
1.0
|
CB
|
A:CYS83
|
3.3
|
29.8
|
1.0
|
CB
|
A:HIS87
|
3.8
|
30.3
|
1.0
|
CA
|
A:CYS83
|
3.9
|
31.1
|
1.0
|
NE2
|
A:HIS87
|
4.0
|
33.3
|
1.0
|
N
|
A:HIS87
|
4.1
|
31.0
|
1.0
|
N
|
A:GLY85
|
4.1
|
36.7
|
1.0
|
CD2
|
A:HIS87
|
4.2
|
30.7
|
1.0
|
CD
|
A:PRO100
|
4.2
|
26.0
|
1.0
|
N
|
A:ASP84
|
4.3
|
33.1
|
1.0
|
CB
|
A:PRO100
|
4.3
|
29.6
|
1.0
|
SG
|
A:CYS74
|
4.4
|
25.9
|
1.0
|
CG
|
A:PRO100
|
4.4
|
28.6
|
1.0
|
CA
|
A:GLY85
|
4.4
|
36.5
|
1.0
|
N
|
A:ALA86
|
4.5
|
31.6
|
1.0
|
C
|
A:CYS83
|
4.5
|
30.7
|
1.0
|
CA
|
A:HIS87
|
4.6
|
34.2
|
1.0
|
C
|
A:GLY85
|
4.6
|
30.8
|
1.0
|
SG
|
A:CYS72
|
4.7
|
25.3
|
1.0
|
CA
|
A:CYS72
|
4.7
|
24.9
|
1.0
|
N
|
A:PRO100
|
4.7
|
26.8
|
1.0
|
CB
|
A:CYS72
|
4.8
|
25.0
|
1.0
|
CA
|
A:PRO100
|
5.0
|
27.9
|
1.0
|
|
Iron binding site 3 out
of 4 in 7p0o
Go back to
Iron Binding Sites List in 7p0o
Iron binding site 3 out
of 4 in the Mitoneet Bound to M1 Molecule
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Mitoneet Bound to M1 Molecule within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Fe201
b:26.1
occ:1.00
|
FE1
|
B:FES201
|
0.0
|
26.1
|
1.0
|
SG
|
B:CYS74
|
2.2
|
25.0
|
1.0
|
S1
|
B:FES201
|
2.2
|
27.4
|
1.0
|
S2
|
B:FES201
|
2.2
|
24.4
|
1.0
|
SG
|
B:CYS72
|
2.3
|
26.0
|
1.0
|
FE2
|
B:FES201
|
2.7
|
27.8
|
1.0
|
CB
|
B:CYS74
|
3.3
|
25.0
|
1.0
|
CB
|
B:CYS72
|
3.4
|
22.0
|
1.0
|
N
|
B:CYS74
|
3.5
|
25.6
|
1.0
|
CA
|
B:CYS72
|
3.7
|
23.5
|
1.0
|
CA
|
B:CYS74
|
3.9
|
25.2
|
1.0
|
N
|
B:ARG73
|
3.9
|
23.2
|
1.0
|
CB
|
B:HIS87
|
4.0
|
29.0
|
1.0
|
C
|
B:CYS72
|
4.2
|
23.1
|
1.0
|
N
|
B:HIS87
|
4.2
|
30.5
|
1.0
|
ND1
|
B:HIS87
|
4.3
|
28.1
|
1.0
|
N
|
B:TRP75
|
4.4
|
26.2
|
1.0
|
N
|
B:SER77
|
4.4
|
28.1
|
1.0
|
C
|
B:CYS74
|
4.4
|
22.8
|
1.0
|
CA
|
B:HIS87
|
4.6
|
30.3
|
1.0
|
CB
|
B:SER77
|
4.6
|
34.3
|
1.0
|
SG
|
B:CYS83
|
4.6
|
29.4
|
1.0
|
C
|
B:ARG73
|
4.6
|
24.6
|
1.0
|
CG
|
B:HIS87
|
4.6
|
27.7
|
1.0
|
N
|
B:ARG76
|
4.6
|
28.2
|
1.0
|
CA
|
B:CYS83
|
4.8
|
29.7
|
1.0
|
CB
|
B:CYS83
|
4.9
|
31.2
|
1.0
|
CA
|
B:ARG73
|
4.9
|
21.1
|
1.0
|
CA
|
B:SER77
|
5.0
|
34.0
|
1.0
|
|
Iron binding site 4 out
of 4 in 7p0o
Go back to
Iron Binding Sites List in 7p0o
Iron binding site 4 out
of 4 in the Mitoneet Bound to M1 Molecule
Mono view
Stereo pair view
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Mitoneet Bound to M1 Molecule within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Fe201
b:27.8
occ:1.00
|
FE2
|
B:FES201
|
0.0
|
27.8
|
1.0
|
ND1
|
B:HIS87
|
2.2
|
28.1
|
1.0
|
S2
|
B:FES201
|
2.2
|
24.4
|
1.0
|
SG
|
B:CYS83
|
2.2
|
29.4
|
1.0
|
S1
|
B:FES201
|
2.3
|
27.4
|
1.0
|
FE1
|
B:FES201
|
2.7
|
26.1
|
1.0
|
CE1
|
B:HIS87
|
3.0
|
27.1
|
1.0
|
CG
|
B:HIS87
|
3.2
|
27.7
|
1.0
|
CB
|
B:CYS83
|
3.4
|
31.2
|
1.0
|
CB
|
B:HIS87
|
3.6
|
29.0
|
1.0
|
CA
|
B:CYS83
|
3.9
|
29.7
|
1.0
|
N
|
B:HIS87
|
4.0
|
30.5
|
1.0
|
N
|
B:GLY85
|
4.0
|
33.4
|
1.0
|
NE2
|
B:HIS87
|
4.1
|
27.4
|
1.0
|
CD
|
B:PRO100
|
4.1
|
26.2
|
1.0
|
CB
|
B:PRO100
|
4.2
|
24.5
|
1.0
|
CD2
|
B:HIS87
|
4.2
|
31.0
|
1.0
|
CA
|
B:GLY85
|
4.3
|
32.7
|
1.0
|
N
|
B:ASP84
|
4.4
|
31.1
|
1.0
|
SG
|
B:CYS74
|
4.4
|
25.0
|
1.0
|
CA
|
B:HIS87
|
4.4
|
30.3
|
1.0
|
CG
|
B:PRO100
|
4.5
|
26.9
|
1.0
|
N
|
B:ALA86
|
4.5
|
28.9
|
1.0
|
C
|
B:CYS83
|
4.5
|
29.6
|
1.0
|
C
|
B:GLY85
|
4.6
|
30.4
|
1.0
|
SG
|
B:CYS72
|
4.6
|
26.0
|
1.0
|
CA
|
B:CYS72
|
4.6
|
23.5
|
1.0
|
N
|
B:PRO100
|
4.7
|
24.7
|
1.0
|
CB
|
B:CYS72
|
4.8
|
22.0
|
1.0
|
CA
|
B:PRO100
|
4.9
|
24.0
|
1.0
|
|
Reference:
H.B.Marjault,
O.Karmi,
K.Zuo,
D.Michaeli,
Y.Eisenberg-Domovich,
G.Rossetti,
B.De Chassey,
J.Vonderscher,
I.Cabantchik,
P.Carloni,
R.Mittler,
O.Livnah,
E.Meldrum,
R.Nechushtai.
An Anti-Diabetic Drug Targets Neet (Cisd) Proteins Through Destabilization of Their [2FE-2S] Clusters. Commun Biol V. 5 437 2022.
ISSN: ESSN 2399-3642
PubMed: 35538231
DOI: 10.1038/S42003-022-03393-X
Page generated: Thu Aug 8 14:51:17 2024
|