Iron in PDB 7qsm: Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)

All present enzymatic activity of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite):
1.6.5.3; 1.6.99.3; 7.1.1.2;

The structure of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) also contains other interesting chemical elements:

Zinc	(Zn)	1 atom
Potassium	(K)	1 atom
Magnesium	(Mg)	1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Iron atom in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) (pdb code 7qsm). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 28 binding sites of Iron where determined in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite), PDB code: 7qsm:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:24.9 occ:1.00 FE1 B:SF4201 0.0 24.9 1.0 SG B:CYS119 2.3 21.4 1.0 S4 B:SF4201 2.3 24.9 1.0 S3 B:SF4201 2.3 24.9 1.0 S2 B:SF4201 2.3 24.9 1.0 FE2 B:SF4201 2.7 24.9 1.0 FE3 B:SF4201 2.7 24.9 1.0 FE4 B:SF4201 2.7 24.9 1.0 CB B:CYS119 3.2 21.4 1.0 O B:HOH345 3.6 19.1 1.0 O B:HOH323 3.9 19.9 1.0 S1 B:SF4201 3.9 24.9 1.0 N B:CYS119 4.0 21.4 1.0 OG1 B:THR91 4.1 25.2 1.0 CA B:CYS119 4.2 21.4 1.0 CQ2 D:2MR85 4.4 25.7 1.0 SG B:CYS149 4.4 20.5 1.0 CE2 B:TYR126 4.7 21.8 1.0 N B:THR91 4.7 25.2 1.0 SG B:CYS55 4.8 24.9 1.0 SG B:CYS54 4.9 25.1 1.0 NH2 D:2MR85 4.9 25.7 1.0 CA B:GLY90 5.0 25.8 1.0

Iron binding site 2 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:24.9 occ:1.00 FE2 B:SF4201 0.0 24.9 1.0 SG B:CYS149 2.3 20.5 1.0 S1 B:SF4201 2.3 24.9 1.0 S3 B:SF4201 2.3 24.9 1.0 S4 B:SF4201 2.3 24.9 1.0 FE4 B:SF4201 2.7 24.9 1.0 FE1 B:SF4201 2.7 24.9 1.0 FE3 B:SF4201 2.8 24.9 1.0 CB B:CYS149 3.4 20.5 1.0 CA B:CYS149 3.4 20.5 1.0 C B:CYS149 3.7 20.5 1.0 O B:HOH345 3.8 19.1 1.0 S2 B:SF4201 3.9 24.9 1.0 NE D:ARG105 4.1 23.0 1.0 N B:PRO150 4.1 23.0 1.0 O B:CYS149 4.1 20.5 1.0 CD2 D:HIS190 4.3 24.7 1.0 NE2 D:HIS190 4.4 24.7 1.0 CA B:PRO150 4.5 23.0 1.0 SG B:CYS119 4.7 21.4 1.0 SG B:CYS55 4.7 24.9 1.0 NH2 D:ARG105 4.7 23.0 1.0 N B:CYS149 4.8 20.5 1.0 CD D:ARG105 4.8 23.0 1.0 SG B:CYS54 4.8 25.1 1.0 CZ D:ARG105 4.8 23.0 1.0 O B:GLY148 4.8 20.7 1.0 CD B:PRO150 5.0 23.0 1.0

Iron binding site 3 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:24.9 occ:1.00 FE3 B:SF4201 0.0 24.9 1.0 S4 B:SF4201 2.3 24.9 1.0 S2 B:SF4201 2.3 24.9 1.0 S1 B:SF4201 2.3 24.9 1.0 SG B:CYS54 2.3 25.1 1.0 FE1 B:SF4201 2.7 24.9 1.0 FE4 B:SF4201 2.8 24.9 1.0 FE2 B:SF4201 2.8 24.9 1.0 CB B:CYS54 2.9 25.1 1.0 CQ2 D:2MR85 3.6 25.7 1.0 NE2 D:HIS190 3.8 24.7 1.0 N B:CYS54 3.8 25.1 1.0 S3 B:SF4201 3.9 24.9 1.0 CA B:CYS54 3.9 25.1 1.0 N B:CYS55 4.2 24.9 1.0 CG D:ARG105 4.4 23.0 1.0 C B:CYS54 4.5 25.1 1.0 CD2 D:HIS190 4.5 24.7 1.0 CB B:ALA53 4.7 26.8 1.0 CE1 D:HIS190 4.8 24.7 1.0 NH2 D:2MR85 4.8 25.7 1.0 SG B:CYS119 4.8 21.4 1.0 SG B:CYS149 4.8 20.5 1.0 NE D:ARG105 4.8 23.0 1.0 CD D:ARG105 4.8 23.0 1.0 SG B:CYS55 4.9 24.9 1.0 CB D:ARG105 4.9 23.0 1.0

Iron binding site 4 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:24.9 occ:1.00 FE4 B:SF4201 0.0 24.9 1.0 S3 B:SF4201 2.3 24.9 1.0 S1 B:SF4201 2.3 24.9 1.0 SG B:CYS55 2.3 24.9 1.0 S2 B:SF4201 2.3 24.9 1.0 FE2 B:SF4201 2.7 24.9 1.0 FE1 B:SF4201 2.7 24.9 1.0 FE3 B:SF4201 2.8 24.9 1.0 CB B:CYS55 3.3 24.9 1.0 O B:HOH323 3.6 19.9 1.0 N B:CYS55 3.6 24.9 1.0 CA B:CYS55 3.8 24.9 1.0 S4 B:SF4201 3.9 24.9 1.0 CB B:PRO150 4.4 23.0 1.0 CB B:CYS54 4.4 25.1 1.0 CA B:PRO150 4.4 23.0 1.0 C B:CYS54 4.5 25.1 1.0 SG B:CYS54 4.7 25.1 1.0 CA B:GLY117 4.7 21.9 1.0 N B:PRO150 4.8 23.0 1.0 CA B:GLY90 4.8 25.8 1.0 N B:CYS54 4.8 25.1 1.0 CA B:CYS149 4.8 20.5 1.0 SG B:CYS149 4.8 20.5 1.0 SG B:CYS119 4.8 21.4 1.0 CA B:CYS54 4.9 25.1 1.0

Iron binding site 5 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:42.8 occ:1.00 FE1 E:FES301 0.0 42.8 1.0 S1 E:FES301 2.2 42.8 1.0 S2 E:FES301 2.2 42.8 1.0 SG E:CYS108 2.3 41.5 1.0 SG E:CYS103 2.3 40.7 1.0 FE2 E:FES301 2.7 42.8 1.0 CB E:CYS108 3.2 41.5 1.0 CB E:CYS103 3.3 40.7 1.0 CA E:CYS144 4.0 38.5 1.0 N E:CYS108 4.1 41.5 1.0 CA E:CYS108 4.3 41.5 1.0 N E:LEU145 4.3 40.4 1.0 SG E:CYS144 4.5 38.5 1.0 CB E:CYS144 4.5 38.5 1.0 CA E:CYS103 4.6 40.7 1.0 C E:CYS103 4.7 40.7 1.0 SG E:CYS148 4.7 42.5 1.0 C E:CYS144 4.7 38.5 1.0 SD E:MET153 4.7 44.2 1.0 CA E:CYS148 4.8 42.5 1.0 O E:CYS103 4.8 40.7 1.0 O E:THR105 4.8 39.1 1.0 CB E:THR105 4.8 39.1 1.0 N E:THR105 4.9 39.1 1.0 N E:CYS144 4.9 38.5 1.0 CG E:MET153 4.9 44.2 1.0

Iron binding site 6 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:42.8 occ:1.00 FE2 E:FES301 0.0 42.8 1.0 S2 E:FES301 2.2 42.8 1.0 S1 E:FES301 2.2 42.8 1.0 SG E:CYS148 2.3 42.5 1.0 SG E:CYS144 2.3 38.5 1.0 FE1 E:FES301 2.7 42.8 1.0 CB E:CYS144 3.2 38.5 1.0 CB E:CYS148 3.3 42.5 1.0 CA E:CYS144 3.6 38.5 1.0 CA E:CYS148 3.7 42.5 1.0 N E:CYS148 3.8 42.5 1.0 N E:LEU145 3.9 40.4 1.0 N E:GLY146 4.1 41.1 1.0 C E:CYS144 4.2 38.5 1.0 N F:GLY103 4.2 40.6 1.0 SG E:CYS103 4.3 40.7 1.0 N E:ALA147 4.3 42.6 1.0 SG E:CYS108 4.5 41.5 1.0 C E:ALA147 4.6 42.6 1.0 CB E:PRO107 4.7 40.7 1.0 CA E:GLY146 4.7 41.1 1.0 CG E:PRO107 4.8 40.7 1.0 CA F:PRO102 4.8 38.0 1.0 N E:CYS144 4.9 38.5 1.0 CA F:GLY103 5.0 40.6 1.0 C E:GLY146 5.0 41.1 1.0 C E:LEU145 5.0 40.4 1.0

Iron binding site 7 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:28.9 occ:1.00 FE1 F:SF4501 0.0 28.9 1.0 SG F:CYS362 2.3 24.2 1.0 S3 F:SF4501 2.3 28.9 1.0 S4 F:SF4501 2.3 28.9 1.0 S2 F:SF4501 2.3 28.9 1.0 FE2 F:SF4501 2.7 28.9 1.0 FE3 F:SF4501 2.8 28.9 1.0 FE4 F:SF4501 2.8 28.9 1.0 CB F:CYS362 3.4 24.2 1.0 N F:CYS362 3.7 24.2 1.0 S1 F:SF4501 3.9 28.9 1.0 CA F:CYS362 4.0 24.2 1.0 CB F:CYS365 4.1 25.9 1.0 N F:ILE404 4.2 25.6 1.0 O F:CYS362 4.3 24.2 1.0 CB F:ILE404 4.3 25.6 1.0 CB F:THR403 4.4 26.6 1.0 SG F:CYS365 4.5 25.9 1.0 C F:CYS362 4.5 24.2 1.0 N F:CYS405 4.6 27.5 1.0 CB F:GLN361 4.7 26.0 1.0 CG1 F:ILE404 4.7 25.6 1.0 CA F:ILE404 4.8 25.6 1.0 C F:GLN361 4.8 26.0 1.0 SG F:CYS359 4.8 27.7 1.0 N F:GLN361 4.8 26.0 1.0 CD1 F:ILE404 4.8 25.6 1.0 SG F:CYS405 4.9 27.5 1.0 CG2 F:THR403 4.9 26.6 1.0

Iron binding site 8 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:28.9 occ:1.00 FE2 F:SF4501 0.0 28.9 1.0 SG F:CYS365 2.2 25.9 1.0 S4 F:SF4501 2.3 28.9 1.0 S3 F:SF4501 2.3 28.9 1.0 S1 F:SF4501 2.3 28.9 1.0 FE1 F:SF4501 2.7 28.9 1.0 FE4 F:SF4501 2.7 28.9 1.0 FE3 F:SF4501 2.7 28.9 1.0 CB F:CYS365 2.9 25.9 1.0 OG F:SER358 3.6 30.0 1.0 S2 F:SF4501 3.9 28.9 1.0 CD2 F:LEU407 4.1 30.8 1.0 N F:CYS359 4.4 27.7 1.0 CB F:SER358 4.4 30.0 1.0 CA F:CYS365 4.4 25.9 1.0 CA F:SER358 4.5 30.0 1.0 CB F:LEU407 4.5 30.8 1.0 SG F:CYS362 4.6 24.2 1.0 N F:GLY408 4.6 30.4 1.0 SG F:CYS405 4.7 27.5 1.0 C F:CYS365 4.8 25.9 1.0 CG F:LEU407 4.8 30.8 1.0 SG F:CYS359 4.8 27.7 1.0 N F:GLY360 4.8 26.5 1.0 C F:SER358 4.9 30.0 1.0 N F:ARG366 4.9 25.8 1.0

Iron binding site 9 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:28.9 occ:1.00 FE3 F:SF4501 0.0 28.9 1.0 S4 F:SF4501 2.3 28.9 1.0 SG F:CYS405 2.3 27.5 1.0 S2 F:SF4501 2.3 28.9 1.0 S1 F:SF4501 2.3 28.9 1.0 FE4 F:SF4501 2.7 28.9 1.0 FE2 F:SF4501 2.7 28.9 1.0 FE1 F:SF4501 2.8 28.9 1.0 CB F:CYS405 3.3 27.5 1.0 N F:CYS405 3.8 27.5 1.0 S3 F:SF4501 3.9 28.9 1.0 CA F:CYS405 4.0 27.5 1.0 CB F:LEU407 4.1 30.8 1.0 CG F:PRO203 4.1 29.0 1.0 CD1 F:ILE185 4.3 30.8 1.0 C F:CYS405 4.3 27.5 1.0 O F:CYS405 4.4 27.5 1.0 CD F:PRO203 4.6 29.0 1.0 N F:LEU407 4.6 30.8 1.0 SG F:CYS359 4.7 27.7 1.0 N F:GLY408 4.8 30.4 1.0 SG F:CYS365 4.8 25.9 1.0 SG F:CYS362 4.8 24.2 1.0 CA F:LEU407 4.9 30.8 1.0 C F:ILE404 5.0 25.6 1.0 CB F:PRO203 5.0 29.0 1.0

Iron binding site 10 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Bovine Complex I in Lipid Nanodisc, Deactive-Ligand (Composite) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:28.9 occ:1.00 FE4 F:SF4501 0.0 28.9 1.0 SG F:CYS359 2.3 27.7 1.0 S3 F:SF4501 2.3 28.9 1.0 S1 F:SF4501 2.3 28.9 1.0 S2 F:SF4501 2.3 28.9 1.0 FE3 F:SF4501 2.7 28.9 1.0 FE2 F:SF4501 2.7 28.9 1.0 FE1 F:SF4501 2.8 28.9 1.0 CB F:CYS359 3.4 27.7 1.0 N F:CYS359 3.7 27.7 1.0 N F:GLN361 3.8 26.0 1.0 S4 F:SF4501 3.9 28.9 1.0 CA F:CYS359 3.9 27.7 1.0 N F:GLY360 3.9 26.5 1.0 CB F:GLN361 3.9 26.0 1.0 C F:CYS359 4.2 27.7 1.0 CD F:PRO203 4.3 29.0 1.0 CA F:GLN361 4.4 26.0 1.0 N F:CYS362 4.5 24.2 1.0 NE2 F:GLN361 4.6 26.0 1.0 C F:GLY360 4.7 26.5 1.0 OG F:SER358 4.8 30.0 1.0 CG F:PRO203 4.8 29.0 1.0 SG F:CYS405 4.8 27.5 1.0 SG F:CYS365 4.8 25.9 1.0 CA F:GLY360 4.8 26.5 1.0 C F:SER358 4.8 30.0 1.0 SG F:CYS362 4.9 24.2 1.0 CD1 F:ILE185 5.0 30.8 1.0

I.Chung, J.J.Wright, H.R.Bridges, B.S.Ivanov, O.Biner, C.S.Pereira, G.M.Arantes, J.Hirst. Cryo-Em Structures Define Ubiquinone-10 Binding to Mitochondrial Complex I and Conformational Transitions Accompanying Q-Site Occupancy. Nat Commun V. 13 2758 2022.
ISSN: ESSN 2041-1723
PubMed: 35589726
DOI: 10.1038/S41467-022-30506-1