Iron in PDB 7qsn: Bovine Complex I in Lipid Nanodisc, Deactive-Apo

All present enzymatic activity of Bovine Complex I in Lipid Nanodisc, Deactive-Apo:
1.6.5.3; 1.6.99.3; 7.1.1.2;

The structure of Bovine Complex I in Lipid Nanodisc, Deactive-Apo also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Potassium	(K)	1 atom
Zinc	(Zn)	1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Iron atom in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo (pdb code 7qsn). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 28 binding sites of Iron where determined in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo, PDB code: 7qsn:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.6 occ:1.00 FE1 B:SF4201 0.0 31.6 1.0 SG B:CYS119 2.2 30.1 1.0 S4 B:SF4201 2.3 31.6 1.0 S3 B:SF4201 2.3 31.6 1.0 S2 B:SF4201 2.3 31.6 1.0 FE2 B:SF4201 2.7 31.6 1.0 FE3 B:SF4201 2.7 31.6 1.0 FE4 B:SF4201 2.7 31.6 1.0 CB B:CYS119 3.1 30.1 1.0 O B:HOH328 3.5 28.0 1.0 S1 B:SF4201 3.9 31.6 1.0 OG1 B:THR91 4.0 33.5 1.0 N B:CYS119 4.0 30.1 1.0 CA B:CYS119 4.1 30.1 1.0 O B:HOH307 4.2 31.0 1.0 SG B:CYS149 4.4 28.5 1.0 CQ2 D:2MR85 4.4 33.0 1.0 CE2 B:TYR126 4.7 29.6 1.0 SG B:CYS55 4.8 33.0 1.0 N B:THR91 4.8 33.5 1.0 SG B:CYS54 4.9 33.1 1.0 NH2 D:2MR85 4.9 33.0 1.0

Iron binding site 2 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.6 occ:1.00 FE2 B:SF4201 0.0 31.6 1.0 SG B:CYS149 2.2 28.5 1.0 S1 B:SF4201 2.3 31.6 1.0 S3 B:SF4201 2.3 31.6 1.0 S4 B:SF4201 2.3 31.6 1.0 FE4 B:SF4201 2.7 31.6 1.0 FE1 B:SF4201 2.7 31.6 1.0 FE3 B:SF4201 2.7 31.6 1.0 CA B:CYS149 3.4 28.5 1.0 CB B:CYS149 3.4 28.5 1.0 C B:CYS149 3.6 28.5 1.0 O B:HOH328 3.8 28.0 1.0 S2 B:SF4201 3.9 31.6 1.0 O B:CYS149 3.9 28.5 1.0 NE D:ARG105 4.0 29.5 1.0 N B:PRO150 4.0 30.2 1.0 CD2 D:HIS190 4.2 30.7 1.0 NE2 D:HIS190 4.3 30.7 1.0 CA B:PRO150 4.5 30.2 1.0 NH2 D:ARG105 4.5 29.5 1.0 SG B:CYS119 4.6 30.1 1.0 SG B:CYS55 4.7 33.0 1.0 CZ D:ARG105 4.7 29.5 1.0 N B:CYS149 4.8 28.5 1.0 CD D:ARG105 4.8 29.5 1.0 SG B:CYS54 4.8 33.1 1.0 O B:GLY148 4.9 28.3 1.0 CD B:PRO150 4.9 30.2 1.0 CG D:ARG105 4.9 29.5 1.0 CB B:CYS54 4.9 33.1 1.0 CB B:PRO150 5.0 30.2 1.0

Iron binding site 3 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.6 occ:1.00 FE3 B:SF4201 0.0 31.6 1.0 S4 B:SF4201 2.3 31.6 1.0 SG B:CYS54 2.3 33.1 1.0 S2 B:SF4201 2.3 31.6 1.0 S1 B:SF4201 2.3 31.6 1.0 CB B:CYS54 2.7 33.1 1.0 FE1 B:SF4201 2.7 31.6 1.0 FE2 B:SF4201 2.7 31.6 1.0 FE4 B:SF4201 2.8 31.6 1.0 NE2 D:HIS190 3.6 30.7 1.0 CQ2 D:2MR85 3.6 33.0 1.0 N B:CYS54 3.9 33.1 1.0 CA B:CYS54 3.9 33.1 1.0 S3 B:SF4201 3.9 31.6 1.0 CG D:ARG105 4.1 29.5 1.0 N B:CYS55 4.3 33.0 1.0 CD2 D:HIS190 4.4 30.7 1.0 C B:CYS54 4.5 33.1 1.0 CE1 D:HIS190 4.7 30.7 1.0 NE D:ARG105 4.7 29.5 1.0 CD D:ARG105 4.7 29.5 1.0 CB D:ARG105 4.7 29.5 1.0 SG B:CYS119 4.7 30.1 1.0 SG B:CYS149 4.8 28.5 1.0 CB B:ALA53 4.8 35.9 1.0 NH2 D:2MR85 4.8 33.0 1.0 SG B:CYS55 4.9 33.0 1.0

Iron binding site 4 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.6 occ:1.00 FE4 B:SF4201 0.0 31.6 1.0 S3 B:SF4201 2.3 31.6 1.0 S2 B:SF4201 2.3 31.6 1.0 S1 B:SF4201 2.3 31.6 1.0 SG B:CYS55 2.3 33.0 1.0 FE2 B:SF4201 2.7 31.6 1.0 FE1 B:SF4201 2.7 31.6 1.0 FE3 B:SF4201 2.8 31.6 1.0 CB B:CYS55 3.4 33.0 1.0 N B:CYS55 3.5 33.0 1.0 CA B:CYS55 3.9 33.0 1.0 S4 B:SF4201 3.9 31.6 1.0 O B:HOH307 4.0 31.0 1.0 CB B:CYS54 4.0 33.1 1.0 CB B:PRO150 4.2 30.2 1.0 CA B:PRO150 4.3 30.2 1.0 C B:CYS54 4.4 33.1 1.0 SG B:CYS54 4.6 33.1 1.0 N B:PRO150 4.7 30.2 1.0 CA B:CYS54 4.7 33.1 1.0 N B:CYS54 4.7 33.1 1.0 CA B:CYS149 4.8 28.5 1.0 SG B:CYS119 4.8 30.1 1.0 SG B:CYS149 4.8 28.5 1.0 CA B:GLY90 4.9 33.9 1.0 CA B:GLY117 4.9 29.7 1.0 C B:CYS149 4.9 28.5 1.0 CB B:CYS119 5.0 30.1 1.0

Iron binding site 5 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:47.7 occ:1.00 FE1 E:FES301 0.0 47.7 1.0 S2 E:FES301 2.2 47.7 1.0 S1 E:FES301 2.2 47.7 1.0 SG E:CYS103 2.3 43.2 1.0 SG E:CYS108 2.3 44.0 1.0 FE2 E:FES301 2.7 47.7 1.0 CB E:CYS108 3.3 44.0 1.0 CB E:CYS103 3.3 43.2 1.0 CA E:CYS144 4.0 40.8 1.0 N E:CYS108 4.2 44.0 1.0 N E:LEU145 4.2 42.8 1.0 CA E:CYS108 4.3 44.0 1.0 SG E:CYS144 4.4 40.8 1.0 CB E:CYS144 4.6 40.8 1.0 CA E:CYS103 4.6 43.2 1.0 C E:CYS103 4.7 43.2 1.0 C E:CYS144 4.7 40.8 1.0 SG E:CYS148 4.8 46.1 1.0 SD E:MET153 4.8 46.2 1.0 CA E:CYS148 4.8 46.1 1.0 CG E:MET153 4.8 46.2 1.0 N E:CYS144 4.9 40.8 1.0 N E:THR105 4.9 41.4 1.0 O E:CYS103 4.9 43.2 1.0

Iron binding site 6 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:47.7 occ:1.00 FE2 E:FES301 0.0 47.7 1.0 S2 E:FES301 2.2 47.7 1.0 S1 E:FES301 2.2 47.7 1.0 SG E:CYS148 2.3 46.1 1.0 SG E:CYS144 2.3 40.8 1.0 FE1 E:FES301 2.7 47.7 1.0 CB E:CYS144 3.3 40.8 1.0 CB E:CYS148 3.4 46.1 1.0 CA E:CYS148 3.6 46.1 1.0 CA E:CYS144 3.7 40.8 1.0 N E:CYS148 3.8 46.1 1.0 N E:LEU145 3.9 42.8 1.0 N E:GLY146 4.2 43.7 1.0 C E:CYS144 4.3 40.8 1.0 N F:GLY103 4.3 44.1 1.0 SG E:CYS103 4.3 43.2 1.0 N E:ALA147 4.4 45.4 1.0 C E:ALA147 4.5 45.4 1.0 SG E:CYS108 4.5 44.0 1.0 CA F:PRO102 4.7 40.9 1.0 CB E:PRO107 4.8 43.0 1.0 CG E:PRO107 4.8 43.0 1.0 CA E:GLY146 4.8 43.7 1.0 N E:CYS144 5.0 40.8 1.0 O E:ALA147 5.0 45.4 1.0

Iron binding site 7 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:30.6 occ:1.00 FE1 F:SF4502 0.0 30.6 1.0 S3 F:SF4502 2.3 30.6 1.0 S4 F:SF4502 2.3 30.6 1.0 S2 F:SF4502 2.3 30.6 1.0 SG F:CYS362 2.3 29.9 1.0 FE2 F:SF4502 2.7 30.6 1.0 FE4 F:SF4502 2.7 30.6 1.0 FE3 F:SF4502 2.8 30.6 1.0 CB F:CYS362 3.5 29.9 1.0 N F:CYS362 3.8 29.9 1.0 S1 F:SF4502 3.9 30.6 1.0 CB F:CYS365 4.1 29.6 1.0 N F:ILE404 4.1 30.1 1.0 CA F:CYS362 4.1 29.9 1.0 CB F:ILE404 4.2 30.1 1.0 O F:CYS362 4.3 29.9 1.0 CB F:THR403 4.4 30.8 1.0 SG F:CYS365 4.5 29.6 1.0 C F:CYS362 4.6 29.9 1.0 N F:CYS405 4.6 30.5 1.0 CG2 F:THR403 4.7 30.8 1.0 CA F:ILE404 4.7 30.1 1.0 SG F:CYS359 4.7 31.1 1.0 CB F:GLN361 4.8 30.5 1.0 CG1 F:ILE404 4.8 30.1 1.0 SG F:CYS405 4.9 30.5 1.0 C F:GLN361 4.9 30.5 1.0 CD1 F:ILE404 4.9 30.1 1.0 N F:GLN361 5.0 30.5 1.0 CA F:THR403 5.0 30.8 1.0

Iron binding site 8 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:30.6 occ:1.00 FE2 F:SF4502 0.0 30.6 1.0 SG F:CYS365 2.2 29.6 1.0 S4 F:SF4502 2.3 30.6 1.0 S3 F:SF4502 2.3 30.6 1.0 S1 F:SF4502 2.3 30.6 1.0 FE1 F:SF4502 2.7 30.6 1.0 FE3 F:SF4502 2.7 30.6 1.0 FE4 F:SF4502 2.7 30.6 1.0 CB F:CYS365 3.0 29.6 1.0 OG F:SER358 3.4 33.1 1.0 S2 F:SF4502 3.9 30.6 1.0 CD2 F:LEU407 4.0 33.6 1.0 N F:CYS359 4.3 31.1 1.0 CB F:SER358 4.3 33.1 1.0 CA F:CYS365 4.4 29.6 1.0 CA F:SER358 4.4 33.1 1.0 CB F:LEU407 4.6 33.6 1.0 SG F:CYS362 4.6 29.9 1.0 N F:GLY408 4.6 33.6 1.0 SG F:CYS405 4.7 30.5 1.0 C F:CYS365 4.8 29.6 1.0 SG F:CYS359 4.8 31.1 1.0 CG F:LEU407 4.9 33.6 1.0 C F:SER358 4.9 33.1 1.0 N F:ARG366 5.0 30.1 1.0

Iron binding site 9 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:30.6 occ:1.00 FE3 F:SF4502 0.0 30.6 1.0 SG F:CYS405 2.3 30.5 1.0 S4 F:SF4502 2.3 30.6 1.0 S1 F:SF4502 2.3 30.6 1.0 S2 F:SF4502 2.3 30.6 1.0 FE4 F:SF4502 2.7 30.6 1.0 FE2 F:SF4502 2.7 30.6 1.0 FE1 F:SF4502 2.8 30.6 1.0 CB F:CYS405 3.4 30.5 1.0 N F:CYS405 3.8 30.5 1.0 S3 F:SF4502 3.9 30.6 1.0 CA F:CYS405 4.0 30.5 1.0 CG F:PRO203 4.2 32.0 1.0 CB F:LEU407 4.2 33.6 1.0 C F:CYS405 4.3 30.5 1.0 CD1 F:ILE185 4.4 34.0 1.0 O F:CYS405 4.5 30.5 1.0 CD F:PRO203 4.6 32.0 1.0 N F:LEU407 4.6 33.6 1.0 N F:GLY408 4.7 33.6 1.0 SG F:CYS359 4.7 31.1 1.0 SG F:CYS365 4.8 29.6 1.0 SG F:CYS362 4.9 29.9 1.0 CA F:LEU407 4.9 33.6 1.0 C F:ILE404 4.9 30.1 1.0 CB F:ILE404 5.0 30.1 1.0 N F:ALA406 5.0 32.8 1.0

Iron binding site 10 out of 28 in the Bovine Complex I in Lipid Nanodisc, Deactive-Apo


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Bovine Complex I in Lipid Nanodisc, Deactive-Apo within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe502 b:30.6 occ:1.00 FE4 F:SF4502 0.0 30.6 1.0 SG F:CYS359 2.3 31.1 1.0 S3 F:SF4502 2.3 30.6 1.0 S1 F:SF4502 2.3 30.6 1.0 S2 F:SF4502 2.3 30.6 1.0 FE3 F:SF4502 2.7 30.6 1.0 FE2 F:SF4502 2.7 30.6 1.0 FE1 F:SF4502 2.7 30.6 1.0 CB F:CYS359 3.4 31.1 1.0 N F:CYS359 3.7 31.1 1.0 S4 F:SF4502 3.9 30.6 1.0 N F:GLN361 3.9 30.5 1.0 CA F:CYS359 4.0 31.1 1.0 CB F:GLN361 4.1 30.5 1.0 N F:GLY360 4.1 30.9 1.0 C F:CYS359 4.3 31.1 1.0 CD F:PRO203 4.3 32.0 1.0 CA F:GLN361 4.6 30.5 1.0 N F:CYS362 4.6 29.9 1.0 OG F:SER358 4.7 33.1 1.0 NE2 F:GLN361 4.7 30.5 1.0 SG F:CYS405 4.8 30.5 1.0 SG F:CYS365 4.8 29.6 1.0 C F:SER358 4.8 33.1 1.0 CG F:PRO203 4.8 32.0 1.0 SG F:CYS362 4.9 29.9 1.0 C F:GLY360 4.9 30.9 1.0

I.Chung, J.J.Wright, H.R.Bridges, B.S.Ivanov, O.Biner, C.S.Pereira, G.M.Arantes, J.Hirst. Cryo-Em Structures Define Ubiquinone-10 Binding to Mitochondrial Complex I and Conformational Transitions Accompanying Q-Site Occupancy. Nat Commun V. 13 2758 2022.
ISSN: ESSN 2041-1723
PubMed: 35589726
DOI: 10.1038/S41467-022-30506-1