Iron in PDB 7u5c: Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State

All present enzymatic activity of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State:
2.7.7.7;

The structure of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Iron atom in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State (pdb code 7u5c). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State, PDB code: 7u5c:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:83.7 occ:1.00 FE1 B:SF4601 0.0 83.7 1.0 S4 B:SF4601 2.3 83.7 1.0 S3 B:SF4601 2.3 83.7 1.0 S2 B:SF4601 2.3 83.7 1.0 FE2 B:SF4601 2.7 83.7 1.0 FE3 B:SF4601 2.7 83.7 1.0 FE4 B:SF4601 2.7 83.7 1.0 SG B:CYS424 3.9 45.7 1.0 S1 B:SF4601 3.9 83.7 1.0 CB B:PRO285 4.1 50.4 1.0 SG B:CYS287 4.1 48.3 1.0 CB B:PRO444 4.2 42.7 1.0 CA B:PRO444 4.5 42.7 1.0 CG B:PRO285 4.6 50.4 1.0 N B:PRO444 4.8 42.7 1.0 CB B:CYS424 4.8 45.7 1.0 CD B:PRO444 5.0 42.7 1.0

Iron binding site 2 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:83.7 occ:1.00 FE2 B:SF4601 0.0 83.7 1.0 S3 B:SF4601 2.3 83.7 1.0 S1 B:SF4601 2.3 83.7 1.0 S4 B:SF4601 2.3 83.7 1.0 FE1 B:SF4601 2.7 83.7 1.0 FE4 B:SF4601 2.7 83.7 1.0 FE3 B:SF4601 2.7 83.7 1.0 CB B:CYS367 3.1 42.3 1.0 S2 B:SF4601 3.9 83.7 1.0 CA B:CYS367 4.1 42.3 1.0 SG B:CYS367 4.4 42.3 1.0 CD1 B:ILE371 4.5 37.6 1.0

Iron binding site 3 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:83.7 occ:1.00 FE3 B:SF4601 0.0 83.7 1.0 S1 B:SF4601 2.3 83.7 1.0 S4 B:SF4601 2.3 83.7 1.0 S2 B:SF4601 2.3 83.7 1.0 FE1 B:SF4601 2.7 83.7 1.0 FE2 B:SF4601 2.7 83.7 1.0 FE4 B:SF4601 2.7 83.7 1.0 SG B:CYS424 3.1 45.7 1.0 CB B:CYS424 3.2 45.7 1.0 S3 B:SF4601 3.9 83.7 1.0 CA B:CYS424 4.5 45.7 1.0 CG B:PRO286 4.6 43.7 1.0 CD1 B:PHE386 4.7 44.2 1.0 CE1 B:PHE386 4.9 44.2 1.0 N B:CYS424 5.0 45.7 1.0 CD B:PRO286 5.0 43.7 1.0

Iron binding site 4 out of 4 in the Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryo-Em Structure of Human Cst Bound to Dna Polymerase Alpha-Primase in A Recruitment State within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:83.7 occ:1.00 FE4 B:SF4601 0.0 83.7 1.0 S1 B:SF4601 2.3 83.7 1.0 S2 B:SF4601 2.3 83.7 1.0 S3 B:SF4601 2.3 83.7 1.0 FE2 B:SF4601 2.7 83.7 1.0 FE1 B:SF4601 2.7 83.7 1.0 FE3 B:SF4601 2.7 83.7 1.0 SG B:CYS287 3.1 48.3 1.0 CB B:CYS287 3.3 48.3 1.0 S4 B:SF4601 3.9 83.7 1.0 N B:CYS287 4.3 48.3 1.0 CA B:CYS287 4.4 48.3 1.0 CD B:PRO385 4.5 48.5 1.0 CA B:CYS384 4.6 50.2 1.0 CB B:CYS384 4.7 50.2 1.0 SG B:CYS384 4.9 50.2 1.0

S.W.Cai, J.C.Zinder, V.Svetlov, M.W.Bush, E.Nudler, T.Walz, T.De Lange. Cryo-Em Structure of the Human Cst-Pol Alpha /Primase Complex in A Recruitment State. Nat.Struct.Mol.Biol. V. 29 813 2022.
ISSN: ESSN 1545-9985
PubMed: 35578024
DOI: 10.1038/S41594-022-00766-Y