Iron in PDB 7u8g: Cryo-Em Structure of the Core Human Nadph Oxidase NOX2

The binding sites of Iron atom in the Cryo-Em Structure of the Core Human Nadph Oxidase NOX2 (pdb code 7u8g). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Cryo-Em Structure of the Core Human Nadph Oxidase NOX2, PDB code: 7u8g:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Cryo-Em Structure of the Core Human Nadph Oxidase NOX2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of the Core Human Nadph Oxidase NOX2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe606 b:28.2 occ:1.00 FE A:HEM606 0.0 28.2 1.0 NC A:HEM606 2.0 28.2 1.0 NE2 A:HIS101 2.0 28.1 1.0 NA A:HEM606 2.0 28.2 1.0 ND A:HEM606 2.1 28.2 1.0 NB A:HEM606 2.1 28.2 1.0 NE2 A:HIS209 2.5 25.7 1.0 HE1 A:HIS209 2.8 25.7 1.0 CE1 A:HIS101 3.0 28.1 1.0 CD2 A:HIS101 3.0 28.1 1.0 CE1 A:HIS209 3.0 25.7 1.0 C1C A:HEM606 3.0 28.2 1.0 C4C A:HEM606 3.1 28.2 1.0 C1B A:HEM606 3.1 28.2 1.0 C4B A:HEM606 3.1 28.2 1.0 C1A A:HEM606 3.1 28.2 1.0 C4A A:HEM606 3.1 28.2 1.0 C1D A:HEM606 3.1 28.2 1.0 C4D A:HEM606 3.1 28.2 1.0 HD2 A:HIS101 3.2 28.1 1.0 HE1 A:HIS101 3.2 28.1 1.0 CHC A:HEM606 3.4 28.2 1.0 CHD A:HEM606 3.4 28.2 1.0 CHB A:HEM606 3.4 28.2 1.0 CHA A:HEM606 3.4 28.2 1.0 CD2 A:HIS209 3.8 25.7 1.0 ND1 A:HIS101 4.1 28.1 1.0 CG A:HIS101 4.1 28.1 1.0 HD2 A:HIS209 4.2 25.7 1.0 C2B A:HEM606 4.3 28.2 1.0 C2C A:HEM606 4.3 28.2 1.0 C3B A:HEM606 4.3 28.2 1.0 C3C A:HEM606 4.3 28.2 1.0 C3A A:HEM606 4.3 28.2 1.0 C2A A:HEM606 4.3 28.2 1.0 C2D A:HEM606 4.3 28.2 1.0 C3D A:HEM606 4.3 28.2 1.0 ND1 A:HIS209 4.3 25.7 1.0 HHC A:HEM606 4.4 28.2 1.0 HHA A:HEM606 4.4 28.2 1.0 HHB A:HEM606 4.4 28.2 1.0 HHD A:HEM606 4.4 28.2 1.0 HD11 A:ILE67 4.6 26.9 1.0 HB1 A:ALA105 4.7 26.4 1.0 CG A:HIS209 4.7 25.7 1.0 HZ A:PHE205 4.8 28.6 1.0 HG21 A:ILE189 4.8 25.2 1.0 HG12 A:VAL71 4.9 31.5 1.0 HD1 A:HIS101 4.9 28.1 1.0 HD1 A:HIS209 5.0 25.7 1.0

Iron binding site 2 out of 2 in the Cryo-Em Structure of the Core Human Nadph Oxidase NOX2


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of the Core Human Nadph Oxidase NOX2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe607 b:22.3 occ:1.00 FE A:HEM607 0.0 22.3 1.0 ND A:HEM607 2.0 22.3 1.0 NB A:HEM607 2.0 22.3 1.0 NC A:HEM607 2.0 22.3 1.0 NA A:HEM607 2.1 22.3 1.0 NE2 A:HIS115 2.1 21.9 1.0 HD2 A:HIS115 2.5 21.9 1.0 NE2 A:HIS222 2.6 21.2 1.0 CD2 A:HIS115 2.6 21.9 1.0 HD2 A:HIS222 3.0 21.2 1.0 C1C A:HEM607 3.1 22.3 1.0 C4B A:HEM607 3.1 22.3 1.0 C4D A:HEM607 3.1 22.3 1.0 C1D A:HEM607 3.1 22.3 1.0 C1B A:HEM607 3.1 22.3 1.0 C1A A:HEM607 3.1 22.3 1.0 C4A A:HEM607 3.1 22.3 1.0 C4C A:HEM607 3.1 22.3 1.0 CD2 A:HIS222 3.2 21.2 1.0 CE1 A:HIS115 3.3 21.9 1.0 CHC A:HEM607 3.4 22.3 1.0 CHA A:HEM607 3.4 22.3 1.0 CHD A:HEM607 3.4 22.3 1.0 CHB A:HEM607 3.4 22.3 1.0 CE1 A:HIS222 3.8 21.2 1.0 HE1 A:HIS115 3.8 21.9 1.0 CG A:HIS115 3.9 21.9 1.0 HD2 A:HIS119 3.9 22.3 1.0 HE1 A:HIS222 4.1 21.2 1.0 ND1 A:HIS115 4.2 21.9 1.0 C3B A:HEM607 4.3 22.3 1.0 C2C A:HEM607 4.3 22.3 1.0 C3D A:HEM607 4.3 22.3 1.0 C2D A:HEM607 4.3 22.3 1.0 C2B A:HEM607 4.3 22.3 1.0 C2A A:HEM607 4.3 22.3 1.0 C3A A:HEM607 4.3 22.3 1.0 C3C A:HEM607 4.3 22.3 1.0 HHD A:HEM607 4.4 22.3 1.0 HHC A:HEM607 4.4 22.3 1.0 HHA A:HEM607 4.4 22.3 1.0 HHB A:HEM607 4.4 22.3 1.0 CG A:HIS222 4.4 21.2 1.0 HD11 A:ILE182 4.6 22.0 1.0 CD2 A:HIS119 4.6 22.3 1.0 ND1 A:HIS222 4.7 21.2 1.0 HA3 A:GLY179 4.9 20.5 1.0 HA2 A:GLY179 4.9 20.5 1.0 NE2 A:HIS119 5.0 22.3 1.0 HD1 A:HIS115 5.0 21.9 1.0

S.Noreng, N.Ota, Y.Sun, H.Ho, M.Johnson, C.P.Arthur, K.Schneider, I.Lehoux, C.W.Davies, K.Mortara, K.Wong, D.Seshasayee, M.Masureel, J.Payandeh, T.Yi, J.T.Koerber. Structure of the Core Human Nadph Oxidase NOX2. Nat Commun V. 13 6079 2022.
ISSN: ESSN 2041-1723
PubMed: 36241643
DOI: 10.1038/S41467-022-33711-0