Iron in PDB 7ujv: Structure of PHD2 in Complex with HIF2A-Codd

All present enzymatic activity of Structure of PHD2 in Complex with HIF2A-Codd:
1.14.11.29;

The structure of Structure of PHD2 in Complex with HIF2A-Codd, PDB code: 7ujv was solved by F.G.Ferens, D.Tarade, J.E.Lee, M.Ohh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.18 / 1.80
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	129.078, 37.597, 42.148, 90, 90, 90
R / Rfree (%)	17.3 / 21.3

The binding sites of Iron atom in the Structure of PHD2 in Complex with HIF2A-Codd (pdb code 7ujv). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Structure of PHD2 in Complex with HIF2A-Codd, PDB code: 7ujv:

Iron binding site 1 out of 1 in the Structure of PHD2 in Complex with HIF2A-Codd


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of PHD2 in Complex with HIF2A-Codd within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe503 b:15.4 occ:1.00 NE2 B:HIS374 2.0 15.4 1.0 O2' B:OGA501 2.0 19.6 1.0 O2 B:OGA501 2.1 17.8 1.0 NE2 B:HIS313 2.1 15.0 1.0 O B:HOH608 2.1 15.5 1.0 OD1 B:ASP315 2.1 17.5 1.0 C2 B:OGA501 2.7 19.9 1.0 C1 B:OGA501 2.8 18.5 1.0 CE1 B:HIS313 3.0 16.7 1.0 CD2 B:HIS374 3.0 16.3 1.0 CE1 B:HIS374 3.0 15.8 1.0 CG B:ASP315 3.1 18.1 1.0 HE1 B:HIS313 3.1 16.1 1.0 CD2 B:HIS313 3.1 15.4 1.0 HD2 B:HIS374 3.2 16.1 1.0 HE1 B:HIS374 3.2 15.7 1.0 OD2 B:ASP315 3.4 16.4 1.0 HD2 B:HIS313 3.4 15.6 1.0 HG3 A:PRO531 3.4 19.2 1.0 HZ B:PHE366 3.9 18.5 1.0 N1 B:OGA501 3.9 19.7 1.0 O1 B:OGA501 4.0 21.5 1.0 CG B:HIS374 4.1 16.3 1.0 ND1 B:HIS374 4.1 15.6 1.0 ND1 B:HIS313 4.1 15.9 1.0 HD3 A:PRO531 4.2 19.5 1.0 HZ2 B:TRP389 4.2 18.6 1.0 CG B:HIS313 4.2 16.6 1.0 O B:HOH633 4.3 23.5 1.0 HA B:ASP315 4.3 17.4 1.0 H4C2 B:OGA501 4.3 20.7 1.0 CG A:PRO531 4.3 19.0 1.0 H4C1 B:OGA501 4.4 20.7 1.0 CB B:ASP315 4.5 17.7 1.0 C4 B:OGA501 4.5 21.1 1.0 H1 B:OGA501 4.6 20.1 1.0 HE2 B:TYR310 4.7 17.8 1.0 HG22 B:THR325 4.7 16.1 1.0 CD A:PRO531 4.7 19.7 1.0 CZ B:PHE366 4.8 17.9 1.0 HG2 A:PRO531 4.8 19.2 1.0 CE2 B:TYR310 4.8 17.9 1.0 CA B:ASP315 4.8 17.4 1.0 HE1 B:PHE366 4.8 18.7 1.0 HE1 B:TRP389 4.9 17.2 1.0 HD1 B:HIS313 4.9 16.1 0.0 HD1 B:HIS374 4.9 15.8 0.0 HB2 B:ASP315 5.0 17.7 1.0 N B:ASP315 5.0 16.3 1.0 H B:ASP315 5.0 16.8 1.0

F.G.Ferens, C.C.Taber, D.Tarade, J.E.Lee, M.Ohh. Structure of PHD2 in Complex with HIF2A-Codd To Be Published.