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Iron in PDB 7ump: Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A ResolutionEnzymatic activity of Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution
All present enzymatic activity of Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution:
1.14.11.29; Protein crystallography data
The structure of Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution, PDB code: 7ump
was solved by
D.R.Davie,
J.Abendroth,
J.Boyd,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7ump:
The structure of Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution
(pdb code 7ump). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution, PDB code: 7ump: Iron binding site 1 out of 1 in 7umpGo back to Iron Binding Sites List in 7ump
Iron binding site 1 out
of 1 in the Crystal Structure of PHD2 Catalytic Domain (Cid 7465) in Complex with Akb-6548 at 1.8 A Resolution
Mono view Stereo pair view
Reference:
A.Zuk,
Z.Si,
S.Loi,
S.Bommegowda,
D.Hoivik,
S.Danthi,
G.Molnar,
V.Csizmadia,
M.Rabinowitz.
Preclinical Characterization of Vadadustat (Akb-6548), An Oral Small Molecule Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, For the Potential Treatment of Renal Anemia. J.Pharmacol.Exp.Ther. V. 383 11 2022.
Page generated: Wed Apr 5 05:26:15 2023
ISSN: ESSN 1521-0103 PubMed: 35926869 DOI: 10.1124/JPET.122.001126 |
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