Iron in PDB 7v4n: Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction

The structure of Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction, PDB code: 7v4n was solved by T.L.Li, M.Z.Saeid, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.83 / 2.20
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	82.243, 82.243, 104.251, 90, 90, 90
R / Rfree (%)	18.7 / 25.2

The binding sites of Iron atom in the Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction (pdb code 7v4n). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction, PDB code: 7v4n:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe201 b:49.0 occ:0.50 OE1 A:GLU89 2.3 26.7 1.0 OD2 A:ASP92 2.4 28.4 1.0 CG A:ASP92 3.5 31.5 1.0 CD A:GLU89 3.5 35.5 1.0 CB A:ASP92 3.9 30.2 1.0 OE2 A:GLU89 4.2 35.1 1.0 CA A:GLU89 4.3 30.2 1.0 OD1 A:ASP92 4.5 32.8 1.0 CB A:GLU89 4.5 31.5 1.0 CG A:GLU89 4.6 40.6 1.0 N A:GLU89 5.0 28.0 1.0

Iron binding site 2 out of 2 in the Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Unique Non-Heme Hydroxylase in Biosynthesis of Nucleoside Antibiotic Pathway Uncover Mechanism of Reaction within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:50.9 occ:1.00 O B:ASP140 2.5 26.5 1.0 CE B:LYS141 3.3 64.8 1.0 NZ B:LYS141 3.6 71.3 1.0 C B:ASP140 3.6 20.4 1.0 OD2 B:ASP140 4.0 36.8 1.0 CG B:ASP140 4.2 36.8 1.0 CB B:ASP140 4.3 29.5 1.0 N B:LYS141 4.5 22.1 1.0 CA B:ASP140 4.6 27.2 1.0 O B:HIS139 4.6 28.5 1.0 CA B:LYS141 4.7 29.3 1.0 CD B:LYS141 4.7 64.4 1.0 OD1 B:ASP140 4.9 31.6 1.0

S.M.Zadeh, M.H.Chen, Z.C.Wang, E.K.Astani, I.W.Lo, K.H.Lin, N.S.Hsu, K.Adhikari, S.Y.Lyu, H.Y.Tsai, Y.Terasawa, M.Yabe, K.Yamamoto, S.Ichikawa, T.L.Li. Beta-Hydroxylation of Alpha-Amino-Beta-Hydroxylbutanoyl-Glycyluridine Catalyzed By A Nonheme Hydroxylase Ensures the Maturation of Caprazamycin Commun Chem V. 5 87 2022.
ISSN: ESSN 2399-3669
DOI: 10.1038/S42004-022-00703-6