Iron in PDB 7wiy: Cryo-Em Structure of Human TPH2 Tetramer

All present enzymatic activity of Cryo-Em Structure of Human TPH2 Tetramer:
1.14.16.4;

The binding sites of Iron atom in the Cryo-Em Structure of Human TPH2 Tetramer (pdb code 7wiy). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Cryo-Em Structure of Human TPH2 Tetramer, PDB code: 7wiy:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Cryo-Em Structure of Human TPH2 Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Human TPH2 Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe501 b:35.7 occ:1.00 NE2 B:HIS323 2.0 22.6 1.0 OE2 B:GLU363 2.1 27.3 1.0 NE2 B:HIS318 2.2 32.4 1.0 CD2 B:HIS323 2.8 22.6 1.0 CE1 B:HIS318 3.1 32.4 1.0 CE1 B:HIS323 3.1 22.6 1.0 CD B:GLU363 3.2 27.3 1.0 CD2 B:HIS318 3.3 32.4 1.0 N3 B:IMD502 3.3 30.8 1.0 C2 B:IMD502 3.4 30.8 1.0 C4 B:IMD502 3.5 30.8 1.0 HN3 B:IMD502 3.6 30.8 1.0 N1 B:IMD502 3.7 30.8 1.0 C5 B:IMD502 3.7 30.8 1.0 OE1 B:GLU363 3.8 27.3 1.0 H2 B:IMD502 3.8 30.8 1.0 H4 B:IMD502 3.9 30.8 1.0 CG B:HIS323 4.0 22.6 1.0 ND1 B:HIS323 4.1 22.6 1.0 HN1 B:IMD502 4.2 30.8 1.0 ND1 B:HIS318 4.2 32.4 1.0 H5 B:IMD502 4.2 30.8 1.0 CB B:ALA378 4.2 28.0 1.0 CG B:HIS318 4.4 32.4 1.0 CG B:GLU363 4.4 27.3 1.0 OH B:TYR358 4.9 26.1 1.0

Iron binding site 2 out of 4 in the Cryo-Em Structure of Human TPH2 Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Human TPH2 Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe501 b:37.5 occ:1.00 HN3 C:IMD502 1.5 32.4 1.0 H2 C:IMD502 1.8 32.4 1.0 N3 C:IMD502 1.9 32.4 1.0 NE2 C:HIS323 1.9 23.6 1.0 NE2 C:HIS318 2.0 32.5 1.0 C2 C:IMD502 2.1 32.4 1.0 OE2 C:GLU363 2.4 28.1 1.0 CD2 C:HIS323 2.5 23.6 1.0 CE1 C:HIS318 2.8 32.5 1.0 CD2 C:HIS318 3.1 32.5 1.0 CE1 C:HIS323 3.1 23.6 1.0 C4 C:IMD502 3.3 32.4 1.0 N1 C:IMD502 3.4 32.4 1.0 CD C:GLU363 3.5 28.1 1.0 CB C:ALA378 3.7 27.4 1.0 CG C:HIS323 3.8 23.6 1.0 H4 C:IMD502 3.9 32.4 1.0 OE1 C:GLU363 4.0 28.1 1.0 C5 C:IMD502 4.0 32.4 1.0 ND1 C:HIS318 4.0 32.5 1.0 ND1 C:HIS323 4.0 23.6 1.0 CG C:HIS318 4.1 32.5 1.0 HN1 C:IMD502 4.1 32.4 1.0 CG C:GLU363 4.7 28.1 1.0 O C:HIS318 4.8 32.5 1.0 H5 C:IMD502 4.9 32.4 1.0 CG C:GLU319 4.9 30.6 1.0

Iron binding site 3 out of 4 in the Cryo-Em Structure of Human TPH2 Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Human TPH2 Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe501 b:35.7 occ:1.00 HN3 D:IMD502 1.5 31.7 1.0 H2 D:IMD502 1.8 31.7 1.0 NE2 D:HIS323 1.9 23.5 1.0 N3 D:IMD502 1.9 31.7 1.0 NE2 D:HIS318 2.0 32.7 1.0 C2 D:IMD502 2.1 31.7 1.0 OE2 D:GLU363 2.4 27.6 1.0 CD2 D:HIS323 2.5 23.5 1.0 CE1 D:HIS318 2.9 32.7 1.0 CD2 D:HIS318 3.0 32.7 1.0 CE1 D:HIS323 3.1 23.5 1.0 C4 D:IMD502 3.3 31.7 1.0 N1 D:IMD502 3.4 31.7 1.0 CD D:GLU363 3.4 27.6 1.0 CG D:HIS323 3.8 23.5 1.0 H4 D:IMD502 3.9 31.7 1.0 CB D:ALA378 3.9 27.4 1.0 OE1 D:GLU363 3.9 27.6 1.0 C5 D:IMD502 4.0 31.7 1.0 ND1 D:HIS323 4.0 23.5 1.0 ND1 D:HIS318 4.0 32.7 1.0 CG D:HIS318 4.1 32.7 1.0 HN1 D:IMD502 4.1 31.7 1.0 CG D:GLU363 4.6 27.6 1.0 O D:HIS318 4.8 32.7 1.0 CG D:GLU319 4.8 31.1 1.0 H5 D:IMD502 4.9 31.7 1.0

Iron binding site 4 out of 4 in the Cryo-Em Structure of Human TPH2 Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Cryo-Em Structure of Human TPH2 Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe501 b:37.1 occ:1.00 H5 A:IMD502 1.5 32.4 1.0 NE2 A:HIS323 1.9 23.0 1.0 OE2 A:GLU363 2.1 27.8 1.0 C5 A:IMD502 2.1 32.4 1.0 NE2 A:HIS318 2.1 32.8 1.0 CD2 A:HIS323 2.7 23.0 1.0 C4 A:IMD502 2.9 32.4 1.0 CE1 A:HIS318 2.9 32.8 1.0 N1 A:IMD502 3.0 32.4 1.0 CE1 A:HIS323 3.1 23.0 1.0 H4 A:IMD502 3.1 32.4 1.0 CD A:GLU363 3.2 27.8 1.0 CD2 A:HIS318 3.2 32.8 1.0 HN1 A:IMD502 3.3 32.4 1.0 OE1 A:GLU363 3.8 27.8 1.0 N3 A:IMD502 3.9 32.4 1.0 CG A:HIS323 4.0 23.0 1.0 C2 A:IMD502 4.0 32.4 1.0 ND1 A:HIS323 4.1 23.0 1.0 CB A:ALA378 4.1 28.2 1.0 ND1 A:HIS318 4.1 32.8 1.0 CG A:HIS318 4.3 32.8 1.0 CG A:GLU363 4.4 27.8 1.0 HN3 A:IMD502 4.8 32.4 1.0 H2 A:IMD502 4.8 32.4 1.0 OH A:TYR358 4.9 26.1 1.0

K.Zhu, C.Liu, Y.Gao, J.Lu, D.Wang, H.Zhang. Cryo-Em Structure and Activator Screening of Human Tryptophan Hydroxylase 2. Front Pharmacol V. 13 07437 2022.
ISSN: ESSN 1663-9812
PubMed: 36046836
DOI: 10.3389/FPHAR.2022.907437