Iron in PDB 7x53: Cytochrome P450 Monooxygenase

The structure of Cytochrome P450 Monooxygenase, PDB code: 7x53 was solved by Y.Yan, C.Zheng, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.51 / 3.35
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	79.831, 55.63, 88.023, 90, 102.94, 90
R / Rfree (%)	27 / 32.1

The binding sites of Iron atom in the Cytochrome P450 Monooxygenase (pdb code 7x53). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Cytochrome P450 Monooxygenase, PDB code: 7x53:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Cytochrome P450 Monooxygenase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cytochrome P450 Monooxygenase within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe601 b:38.4 occ:1.00 FE A:HEM601 0.0 38.4 1.0 ND A:HEM601 2.0 38.5 1.0 NB A:HEM601 2.0 39.4 1.0 NC A:HEM601 2.0 39.1 1.0 NA A:HEM601 2.1 38.7 1.0 SG A:CYS361 2.3 39.5 1.0 C4A A:HEM601 3.0 39.0 1.0 C1B A:HEM601 3.0 39.4 1.0 C1D A:HEM601 3.0 39.2 1.0 C4C A:HEM601 3.1 39.7 1.0 C1A A:HEM601 3.1 38.6 1.0 C1C A:HEM601 3.1 40.3 1.0 C4D A:HEM601 3.1 38.7 1.0 C4B A:HEM601 3.1 40.0 1.0 CHB A:HEM601 3.4 39.3 1.0 CHD A:HEM601 3.4 39.7 1.0 CHA A:HEM601 3.5 38.7 1.0 CHC A:HEM601 3.5 39.6 1.0 CB A:CYS361 3.5 38.9 1.0 C3A A:HEM601 4.2 38.8 1.0 O A:ALA250 4.2 41.5 1.0 C2A A:HEM601 4.2 38.3 1.0 C2B A:HEM601 4.3 39.9 1.0 C3C A:HEM601 4.3 39.4 1.0 C2D A:HEM601 4.3 39.2 1.0 C2C A:HEM601 4.3 39.2 1.0 C3B A:HEM601 4.3 40.2 1.0 C3D A:HEM601 4.3 39.1 1.0 CA A:CYS361 4.3 38.7 1.0 OG1 A:THR254 4.5 41.9 1.0 CG2 A:THR254 4.7 42.2 1.0 CB A:THR254 4.9 42.0 1.0

Iron binding site 2 out of 2 in the Cytochrome P450 Monooxygenase


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cytochrome P450 Monooxygenase within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:38.2 occ:1.00 FE B:HEM601 0.0 38.2 1.0 NB B:HEM601 2.0 38.9 1.0 ND B:HEM601 2.0 37.4 1.0 NC B:HEM601 2.1 38.2 1.0 NA B:HEM601 2.1 37.1 1.0 SG B:CYS361 2.3 37.9 1.0 C4A B:HEM601 3.1 37.4 1.0 C1A B:HEM601 3.1 37.2 1.0 C4D B:HEM601 3.1 37.4 1.0 C1C B:HEM601 3.1 39.4 1.0 C4B B:HEM601 3.1 39.4 1.0 C1B B:HEM601 3.1 38.9 1.0 C1D B:HEM601 3.1 37.5 1.0 C4C B:HEM601 3.1 38.2 1.0 CHA B:HEM601 3.4 37.4 1.0 CHB B:HEM601 3.4 37.9 1.0 CHC B:HEM601 3.4 39.6 1.0 CHD B:HEM601 3.4 37.7 1.0 CB B:CYS361 3.6 37.8 1.0 C3A B:HEM601 4.3 37.7 1.0 C2A B:HEM601 4.3 37.1 1.0 C3D B:HEM601 4.3 37.4 1.0 C2D B:HEM601 4.3 37.5 1.0 C2B B:HEM601 4.3 39.7 1.0 C3B B:HEM601 4.3 40.0 1.0 C2C B:HEM601 4.3 39.0 1.0 C3C B:HEM601 4.3 38.6 1.0 CA B:CYS361 4.4 36.8 1.0 O B:ALA250 4.5 41.8 1.0 OG1 B:THR254 4.7 42.6 1.0 CG2 B:THR254 5.0 43.6 1.0

Y.Yan, C.Zheng, S.Wei, W.Jing, G.Liang, G.Cong, L.Jia, C.Xiulai, L.Liming. Structure of Cytochrome P450 Monooxygenase at 3.35 Angstroms Resolution. To Be Published.