Iron in PDB 8d3m: Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer

Enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer

All present enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer:
3.1.12.1;

Other elements in 8d3m:

The structure of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer (pdb code 8d3m). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer, PDB code: 8d3m:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 8d3m

Go back to Iron Binding Sites List in 8d3m
Iron binding site 1 out of 4 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE1 I:SF4301 0.0 54.6 1.0
SG I:CYS190 2.1 54.9 1.0
S2 I:SF4301 2.3 54.6 1.0
S3 I:SF4301 2.3 54.6 1.0
S4 I:SF4301 2.3 54.6 1.0
SG I:CYS21 2.3 50.9 1.0
FE4 I:SF4301 2.7 54.6 1.0
FE3 I:SF4301 2.7 54.6 1.0
FE2 I:SF4301 2.7 54.6 1.0
CE1 I:PHE189 3.4 57.7 1.0
SG I:CYS193 3.8 51.2 1.0
S1 I:SF4301 3.9 54.6 1.0
CD1 I:PHE189 3.9 57.7 1.0
CB I:CYS190 3.9 54.9 1.0
CB I:CYS21 4.0 50.9 1.0
SG I:CYS199 4.2 47.6 1.0
CZ I:PHE189 4.4 57.7 1.0
CG2 I:VAL184 4.7 53.0 1.0
CA I:CYS190 4.8 54.9 1.0
CB I:CYS193 4.8 51.2 1.0
N I:CYS190 5.0 54.9 1.0

Iron binding site 2 out of 4 in 8d3m

Go back to Iron Binding Sites List in 8d3m
Iron binding site 2 out of 4 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE2 I:SF4301 0.0 54.6 1.0
SG I:CYS190 2.2 54.9 1.0
S1 I:SF4301 2.3 54.6 1.0
S4 I:SF4301 2.3 54.6 1.0
S3 I:SF4301 2.3 54.6 1.0
SG I:CYS199 2.3 47.6 1.0
SG I:CYS193 2.4 51.2 1.0
FE3 I:SF4301 2.7 54.6 1.0
FE4 I:SF4301 2.7 54.6 1.0
FE1 I:SF4301 2.7 54.6 1.0
CB I:CYS193 3.2 51.2 1.0
CB I:CYS190 3.3 54.9 1.0
S2 I:SF4301 3.9 54.6 1.0
CB I:CYS199 4.0 47.6 1.0
CA I:CYS190 4.2 54.9 1.0
SG I:CYS21 4.4 50.9 1.0
CG I:PRO201 4.4 54.0 1.0
CA I:CYS193 4.7 51.2 1.0
O I:LEU195 4.7 46.8 1.0
CA I:GLN196 4.8 47.0 1.0
C I:LEU195 4.9 46.8 1.0
N I:GLN196 4.9 47.0 1.0

Iron binding site 3 out of 4 in 8d3m

Go back to Iron Binding Sites List in 8d3m
Iron binding site 3 out of 4 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE3 I:SF4301 0.0 54.6 1.0
S4 I:SF4301 2.3 54.6 1.0
S1 I:SF4301 2.3 54.6 1.0
S2 I:SF4301 2.3 54.6 1.0
SG I:CYS199 2.4 47.6 1.0
FE2 I:SF4301 2.7 54.6 1.0
FE1 I:SF4301 2.7 54.6 1.0
FE4 I:SF4301 2.7 54.6 1.0
CB I:CYS199 2.9 47.6 1.0
CD I:ARG23 3.4 45.1 1.0
SG I:CYS21 3.5 50.9 1.0
CB I:ARG23 3.9 45.1 1.0
S3 I:SF4301 3.9 54.6 1.0
SG I:CYS190 3.9 54.9 1.0
CG I:ARG23 4.0 45.1 1.0
SG I:CYS193 4.3 51.2 1.0
NE I:ARG23 4.3 45.1 1.0
CA I:CYS199 4.4 47.6 1.0
N I:GLN24 4.9 45.0 1.0
C I:CYS199 4.9 47.6 1.0
O I:CYS199 4.9 47.6 1.0
C I:ARG23 5.0 45.1 1.0

Iron binding site 4 out of 4 in 8d3m

Go back to Iron Binding Sites List in 8d3m
Iron binding site 4 out of 4 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Processed Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE4 I:SF4301 0.0 54.6 1.0
S3 I:SF4301 2.3 54.6 1.0
S2 I:SF4301 2.3 54.6 1.0
S1 I:SF4301 2.3 54.6 1.0
SG I:CYS193 2.3 51.2 1.0
SG I:CYS21 2.6 50.9 1.0
FE1 I:SF4301 2.7 54.6 1.0
FE2 I:SF4301 2.7 54.6 1.0
FE3 I:SF4301 2.7 54.6 1.0
CB I:CYS21 3.4 50.9 1.0
CB I:GLN24 3.7 45.0 1.0
SG I:CYS190 3.8 54.9 1.0
S4 I:SF4301 3.9 54.6 1.0
SG I:CYS199 3.9 47.6 1.0
CB I:CYS193 4.0 51.2 1.0
CG I:GLN24 4.1 45.0 1.0
NE2 I:GLN24 4.1 45.0 1.0
CA I:GLN24 4.1 45.0 1.0
N I:GLN24 4.2 45.0 1.0
CD I:GLN24 4.6 45.0 1.0
CA I:CYS21 4.8 50.9 1.0
CB I:CYS199 4.9 47.6 1.0
CE2 I:PHE20 5.0 55.2 1.0

Reference:

Y.Dhingra, S.K.Suresh, P.Juneja, D.G.Sashital. Pam Binding Ensures Orientational Integration During CAS4-CAS1-CAS2-Mediated Crispr Adaptation. Mol.Cell V. 82 4353 2022.
ISSN: ISSN 1097-2765
PubMed: 36272411
DOI: 10.1016/J.MOLCEL.2022.09.030
Page generated: Wed Apr 5 08:20:55 2023

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