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Iron in PDB 8d3q: Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer

Enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer

All present enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer:
3.1.12.1;

Other elements in 8d3q:

The structure of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer (pdb code 8d3q). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer, PDB code: 8d3q:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Iron binding site 1 out of 8 in 8d3q

Go back to Iron Binding Sites List in 8d3q
Iron binding site 1 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:83.5
occ:1.00
 FE1 I:SF4301 0.0 83.5 1.0
S2 I:SF4301 2.3 83.5 1.0
S4 I:SF4301 2.3 83.5 1.0
S3 I:SF4301 2.3 83.5 1.0
SG I:CYS21 2.3 80.9 1.0
SG I:CYS199 2.7 81.5 1.0
FE3 I:SF4301 2.7 83.5 1.0
FE2 I:SF4301 2.7 83.5 1.0
FE4 I:SF4301 2.7 83.5 1.0
SG I:CYS193 3.1 74.8 1.0
CB I:GLN24 3.5 72.8 1.0
N I:GLN24 3.6 72.8 1.0
CB I:CYS21 3.6 80.9 1.0
CA I:GLN24 3.7 72.8 1.0
S1 I:SF4301 3.9 83.5 1.0
CB I:CYS199 3.9 81.5 1.0
SG I:CYS190 4.1 75.2 1.0
CG I:GLN24 4.2 72.8 1.0
C I:ARG23 4.4 77.1 1.0
CB I:ARG23 4.6 77.1 1.0
CB I:CYS193 4.9 74.8 1.0
NE2 I:GLN24 4.9 72.8 1.0
CA I:ARG23 5.0 77.1 1.0
CA I:CYS21 5.0 80.9 1.0
O I:ARG23 5.0 77.1 1.0
CD1 I:LEU27 5.0 63.8 1.0

Iron binding site 2 out of 8 in 8d3q

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Iron binding site 2 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:83.5
occ:1.00
 FE2 I:SF4301 0.0 83.5 1.0
SG I:CYS21 2.2 80.9 1.0
S1 I:SF4301 2.3 83.5 1.0
S3 I:SF4301 2.3 83.5 1.0
SG I:CYS190 2.3 75.2 1.0
S4 I:SF4301 2.3 83.5 1.0
SG I:CYS193 2.6 74.8 1.0
FE4 I:SF4301 2.7 83.5 1.0
FE1 I:SF4301 2.7 83.5 1.0
FE3 I:SF4301 2.7 83.5 1.0
CB I:CYS21 2.9 80.9 1.0
CB I:CYS193 3.8 74.8 1.0
S2 I:SF4301 3.9 83.5 1.0
CE2 I:PHE20 4.0 73.8 1.0
CB I:CYS190 4.1 75.2 1.0
CA I:CYS21 4.2 80.9 1.0
SG I:CYS199 4.4 81.5 1.0
CD2 I:PHE20 4.4 73.8 1.0
CA I:CYS190 4.8 75.2 1.0
CB I:GLN24 4.9 72.8 1.0

Iron binding site 3 out of 8 in 8d3q

Go back to Iron Binding Sites List in 8d3q
Iron binding site 3 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:83.5
occ:1.00
 FE3 I:SF4301 0.0 83.5 1.0
S4 I:SF4301 2.3 83.5 1.0
S2 I:SF4301 2.3 83.5 1.0
S1 I:SF4301 2.3 83.5 1.0
SG I:CYS199 2.3 81.5 1.0
FE1 I:SF4301 2.7 83.5 1.0
FE2 I:SF4301 2.7 83.5 1.0
FE4 I:SF4301 2.7 83.5 1.0
SG I:CYS21 2.9 80.9 1.0
CG I:PRO201 3.2 92.6 1.0
SG I:CYS190 3.2 75.2 1.0
S3 I:SF4301 3.9 83.5 1.0
CB I:CYS199 4.0 81.5 1.0
CB I:PRO201 4.1 92.6 1.0
SG I:CYS193 4.3 74.8 1.0
CD I:PRO201 4.3 92.6 1.0
O I:CYS199 4.6 81.5 1.0
CB I:CYS21 4.6 80.9 1.0
CB I:CYS190 4.7 75.2 1.0
CB I:ARG23 4.8 77.1 1.0
CG1 I:VAL184 4.9 96.0 1.0

Iron binding site 4 out of 8 in 8d3q

Go back to Iron Binding Sites List in 8d3q
Iron binding site 4 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:83.5
occ:1.00
 FE4 I:SF4301 0.0 83.5 1.0
SG I:CYS190 2.2 75.2 1.0
S2 I:SF4301 2.3 83.5 1.0
S1 I:SF4301 2.3 83.5 1.0
SG I:CYS193 2.3 74.8 1.0
S3 I:SF4301 2.3 83.5 1.0
FE2 I:SF4301 2.7 83.5 1.0
FE1 I:SF4301 2.7 83.5 1.0
FE3 I:SF4301 2.7 83.5 1.0
SG I:CYS199 3.1 81.5 1.0
CB I:CYS193 3.2 74.8 1.0
CB I:CYS190 3.4 75.2 1.0
S4 I:SF4301 3.9 83.5 1.0
SG I:CYS21 4.0 80.9 1.0
CG I:PRO201 4.1 92.6 1.0
CA I:GLN196 4.2 60.6 1.0
O I:CYS193 4.4 74.8 1.0
CA I:CYS190 4.5 75.2 1.0
CA I:CYS193 4.5 74.8 1.0
N I:GLN196 4.6 60.6 1.0
C I:CYS193 4.7 74.8 1.0
CG I:GLN196 4.7 60.6 1.0
CB I:GLN196 4.8 60.6 1.0
C I:LEU195 4.8 56.0 1.0
CD I:PRO201 4.8 92.6 1.0
CB I:CYS199 4.8 81.5 1.0
O I:LEU195 4.8 56.0 1.0

Iron binding site 5 out of 8 in 8d3q

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Iron binding site 5 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:156.4
occ:1.00
 FE1 J:SF4301 0.0 156.4 1.0
S3 J:SF4301 2.3 156.4 1.0
S4 J:SF4301 2.3 156.4 1.0
S2 J:SF4301 2.3 156.4 1.0
SG J:CYS193 2.3 149.0 1.0
SG J:CYS199 2.3 123.6 1.0
CB J:CYS199 2.4 123.6 1.0
FE2 J:SF4301 2.7 156.4 1.0
FE3 J:SF4301 2.7 156.4 1.0
FE4 J:SF4301 2.7 156.4 1.0
SG J:CYS190 3.7 142.7 1.0
S1 J:SF4301 3.9 156.4 1.0
CA J:CYS199 3.9 123.6 1.0
CB J:CYS193 4.0 149.0 1.0
O J:LEU195 4.1 124.9 1.0
SG J:CYS21 4.2 146.9 1.0
C J:LEU195 4.2 124.9 1.0
CA J:GLN196 4.3 111.4 1.0
N J:GLN196 4.3 111.4 1.0
N J:CYS199 4.6 123.6 1.0
CB J:LEU195 4.6 124.9 1.0
C J:CYS199 4.6 123.6 1.0
CD1 J:LEU27 4.8 115.5 1.0
CA J:LEU195 4.9 124.9 1.0
O J:CYS193 4.9 149.0 1.0
CB J:GLN196 5.0 111.4 1.0
CG J:PRO201 5.0 123.9 1.0

Iron binding site 6 out of 8 in 8d3q

Go back to Iron Binding Sites List in 8d3q
Iron binding site 6 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:156.4
occ:1.00
 FE2 J:SF4301 0.0 156.4 1.0
SG J:CYS21 2.3 146.9 1.0
S4 J:SF4301 2.3 156.4 1.0
S3 J:SF4301 2.3 156.4 1.0
S1 J:SF4301 2.3 156.4 1.0
SG J:CYS193 2.3 149.0 1.0
FE1 J:SF4301 2.7 156.4 1.0
FE3 J:SF4301 2.7 156.4 1.0
FE4 J:SF4301 2.7 156.4 1.0
CB J:CYS193 2.8 149.0 1.0
CB J:CYS21 3.4 146.9 1.0
S2 J:SF4301 3.9 156.4 1.0
OE1 J:GLN24 4.0 129.6 1.0
SG J:CYS199 4.2 123.6 1.0
CA J:CYS193 4.3 149.0 1.0
SG J:CYS190 4.3 142.7 1.0
CD J:GLN24 4.7 129.6 1.0
CA J:CYS21 4.8 146.9 1.0
N J:CYS193 4.8 149.0 1.0
CB J:GLN24 4.8 129.6 1.0
CA J:CYS190 4.9 142.7 1.0
CB J:CYS199 4.9 123.6 1.0
CE2 J:PHE20 5.0 156.3 1.0
CE1 J:PHE189 5.0 139.4 1.0

Iron binding site 7 out of 8 in 8d3q

Go back to Iron Binding Sites List in 8d3q
Iron binding site 7 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:156.4
occ:1.00
 FE3 J:SF4301 0.0 156.4 1.0
SG J:CYS199 2.3 123.6 1.0
S2 J:SF4301 2.3 156.4 1.0
S4 J:SF4301 2.3 156.4 1.0
S1 J:SF4301 2.3 156.4 1.0
SG J:CYS21 2.3 146.9 1.0
FE2 J:SF4301 2.7 156.4 1.0
FE1 J:SF4301 2.7 156.4 1.0
FE4 J:SF4301 2.7 156.4 1.0
CB J:CYS199 3.7 123.6 1.0
S3 J:SF4301 3.9 156.4 1.0
CB J:CYS21 4.1 146.9 1.0
CB J:ARG23 4.2 120.4 1.0
SG J:CYS193 4.2 149.0 1.0
N J:GLN24 4.5 129.6 1.0
CD1 J:LEU27 4.6 115.5 1.0
CD J:ARG23 4.7 120.4 1.0
SG J:CYS190 4.7 142.7 1.0
CA J:CYS21 4.9 146.9 1.0
C J:ARG23 4.9 120.4 1.0
CA J:CYS199 4.9 123.6 1.0
CG2 J:VAL184 5.0 118.4 1.0
CA J:ARG23 5.0 120.4 1.0
O J:CYS21 5.0 146.9 1.0

Iron binding site 8 out of 8 in 8d3q

Go back to Iron Binding Sites List in 8d3q
Iron binding site 8 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Nopam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:156.4
occ:1.00
 FE4 J:SF4301 0.0 156.4 1.0
SG J:CYS190 2.1 142.7 1.0
S2 J:SF4301 2.3 156.4 1.0
S1 J:SF4301 2.3 156.4 1.0
S3 J:SF4301 2.3 156.4 1.0
FE3 J:SF4301 2.7 156.4 1.0
FE2 J:SF4301 2.7 156.4 1.0
FE1 J:SF4301 2.7 156.4 1.0
CB J:CYS190 3.2 142.7 1.0
SG J:CYS199 3.5 123.6 1.0
SG J:CYS193 3.5 149.0 1.0
SG J:CYS21 3.7 146.9 1.0
CA J:CYS190 3.8 142.7 1.0
S4 J:SF4301 3.9 156.4 1.0
O J:THR186 4.3 128.3 1.0
O J:CYS190 4.5 142.7 1.0
CB J:PRO201 4.6 123.9 1.0
CB J:CYS199 4.6 123.6 1.0
CE1 J:PHE189 4.6 139.4 1.0
CG J:PRO201 4.7 123.9 1.0
C J:CYS190 4.7 142.7 1.0
CB J:CYS193 4.8 149.0 1.0
N J:CYS190 4.9 142.7 1.0
CD1 J:PHE189 5.0 139.4 1.0

Reference:

Y.Dhingra, S.K.Suresh, P.Juneja, D.G.Sashital. Pam Binding Ensures Orientational Integration During CAS4-CAS1-CAS2-Mediated Crispr Adaptation. Mol.Cell V. 82 4353 2022.
ISSN: ISSN 1097-2765
PubMed: 36272411
DOI: 10.1016/J.MOLCEL.2022.09.030
Page generated: Fri Aug 9 23:15:06 2024

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