Iron in PDB 8d4t: Mammalian Civ with Gdn Bound

All present enzymatic activity of Mammalian Civ with Gdn Bound:
7.1.1.9;

The structure of Mammalian Civ with Gdn Bound also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Sodium	(Na)	1 atom
Zinc	(Zn)	1 atom
Copper	(Cu)	3 atoms

The binding sites of Iron atom in the Mammalian Civ with Gdn Bound (pdb code 8d4t). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Mammalian Civ with Gdn Bound, PDB code: 8d4t:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Mammalian Civ with Gdn Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Mammalian Civ with Gdn Bound within 5.0Å range: probe atom residue distance (Å) B Occ N:Fe604 b:19.7 occ:1.00 FE N:HEA604 0.0 19.7 1.0 NE2 N:HIS61 2.0 16.2 1.0 NB N:HEA604 2.0 22.7 1.0 NC N:HEA604 2.0 23.2 1.0 NA N:HEA604 2.0 22.9 1.0 ND N:HEA604 2.0 23.7 1.0 NE2 N:HIS378 2.0 16.4 1.0 CE1 N:HIS378 2.8 18.7 1.0 HE1 N:HIS378 2.8 18.7 1.0 CE1 N:HIS61 2.9 21.6 1.0 C1B N:HEA604 3.0 23.5 1.0 C4A N:HEA604 3.0 23.7 1.0 C4C N:HEA604 3.0 24.9 1.0 C4B N:HEA604 3.0 23.6 1.0 C1C N:HEA604 3.0 24.6 1.0 C4D N:HEA604 3.0 24.9 1.0 C1A N:HEA604 3.1 24.1 1.0 HE1 N:HIS61 3.1 21.6 1.0 CD2 N:HIS61 3.1 21.4 1.0 C1D N:HEA604 3.1 24.1 1.0 CD2 N:HIS378 3.2 17.9 1.0 HD2 N:HIS61 3.3 21.4 1.0 CHB N:HEA604 3.4 21.4 1.0 CHC N:HEA604 3.4 23.5 1.0 CHA N:HEA604 3.4 24.6 1.0 CHD N:HEA604 3.4 22.9 1.0 HD2 N:HIS378 3.5 17.9 1.0 HE2 N:PHE377 3.9 21.8 1.0 ND1 N:HIS378 4.1 17.6 1.0 ND1 N:HIS61 4.1 16.9 1.0 CG N:HIS61 4.1 19.0 1.0 CG N:HIS378 4.2 15.3 1.0 C2B N:HEA604 4.2 24.0 1.0 C2A N:HEA604 4.3 21.3 1.0 C3B N:HEA604 4.3 24.4 1.0 C3A N:HEA604 4.3 23.5 1.0 C3C N:HEA604 4.3 24.0 1.0 C3D N:HEA604 4.3 22.2 1.0 C2C N:HEA604 4.3 25.0 1.0 C2D N:HEA604 4.3 23.6 1.0 HHB N:HEA604 4.4 21.4 1.0 HHC N:HEA604 4.4 23.5 1.0 HHA N:HEA604 4.4 24.6 1.0 HHD N:HEA604 4.4 22.9 1.0 HZ N:PHE425 4.6 23.8 1.0 HE2 N:PHE425 4.7 20.0 1.0 HG3 N:MET65 4.7 26.5 1.0 CE2 N:PHE377 4.8 21.8 1.0 HD1 N:HIS378 4.8 17.6 1.0 HB2 N:SER34 4.8 26.2 1.0 HD1 N:HIS61 4.9 16.9 1.0 HD12 N:ILE37 5.0 22.5 1.0 HB3 N:SER34 5.0 26.2 1.0

Iron binding site 2 out of 2 in the Mammalian Civ with Gdn Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Mammalian Civ with Gdn Bound within 5.0Å range: probe atom residue distance (Å) B Occ N:Fe605 b:19.3 occ:1.00 FE N:HEA605 0.0 19.3 1.0 NA N:HEA605 2.0 19.8 1.0 NC N:HEA605 2.1 19.0 1.0 ND N:HEA605 2.1 18.1 1.0 NB N:HEA605 2.1 18.5 1.0 NE2 N:HIS376 2.3 20.8 1.0 C1A N:HEA605 3.0 18.5 1.0 C4A N:HEA605 3.0 18.8 1.0 C1C N:HEA605 3.1 19.3 1.0 C4C N:HEA605 3.1 20.5 1.0 C4D N:HEA605 3.1 18.4 1.0 C1D N:HEA605 3.1 21.1 1.0 C4B N:HEA605 3.1 22.5 1.0 C1B N:HEA605 3.1 20.7 1.0 CD2 N:HIS376 3.2 20.8 1.0 CE1 N:HIS376 3.3 22.1 1.0 HD2 N:HIS376 3.4 20.8 1.0 HE1 N:HIS376 3.4 22.1 1.0 CHA N:HEA605 3.5 17.6 1.0 CHB N:HEA605 3.5 19.0 1.0 CHC N:HEA605 3.5 20.6 1.0 CHD N:HEA605 3.5 21.2 1.0 C3A N:HEA605 4.2 17.8 1.0 HG21 N:VAL243 4.2 18.2 1.0 C2A N:HEA605 4.2 18.3 1.0 HE1 N:HIS240 4.3 21.7 1.0 HHA N:HEA605 4.4 17.6 1.0 C3C N:HEA605 4.4 21.4 1.0 CG N:HIS376 4.4 20.6 1.0 HHB N:HEA605 4.4 19.0 1.0 C2C N:HEA605 4.4 20.4 1.0 HHC N:HEA605 4.4 20.6 1.0 ND1 N:HIS376 4.4 19.4 1.0 C3D N:HEA605 4.4 17.1 1.0 HHD N:HEA605 4.4 21.2 1.0 C2D N:HEA605 4.5 18.1 1.0 C2B N:HEA605 4.5 18.2 1.0 C3B N:HEA605 4.5 18.9 1.0 HG21 N:VAL380 4.5 22.4 1.0 HA3 N:GLY355 4.5 22.1 1.0 HE1 N:HIS291 4.7 23.9 1.0 HA2 N:GLY355 4.7 22.1 1.0 HB3 N:PHE377 4.7 21.5 1.0 CU N:CU601 4.9 21.0 1.0 HG11 N:VAL243 4.9 17.1 1.0

J.M.Di Trani, A.Moe, D.Riepl, P.Saura, V.R.I.Kaila, P.Brzezinski, J.L.Rubinstein. Structural Basis of Mammalian Complex IV Inhibition By Steroids. Proc.Natl.Acad.Sci.Usa V. 119 28119 2022.
ISSN: ESSN 1091-6490
PubMed: 35858451
DOI: 10.1073/PNAS.2205228119