Iron in PDB 8ebx: Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap)

All present enzymatic activity of Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap):
3.6.4.12;

The structure of Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap) also contains other interesting chemical elements:

Zinc	(Zn)	6 atoms
Calcium	(Ca)	2 atoms

The binding sites of Iron atom in the Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap) (pdb code 8ebx). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap), PDB code: 8ebx:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:301.3 occ:1.00 FE1 B:SF41000 0.0 301.3 1.0 SG B:CYS116 2.3 244.5 1.0 S2 B:SF41000 2.3 301.3 1.0 S4 B:SF41000 2.3 301.3 1.0 S3 B:SF41000 2.3 301.3 1.0 FE3 B:SF41000 2.7 301.3 1.0 FE4 B:SF41000 2.7 301.3 1.0 FE2 B:SF41000 2.7 301.3 1.0 CB B:CYS116 3.5 244.5 1.0 S1 B:SF41000 3.9 301.3 1.0 CA B:CYS116 4.0 244.5 1.0 N B:ILE117 4.2 246.4 1.0 N B:HIS118 4.6 253.3 1.0 C B:CYS116 4.6 244.5 1.0 CB B:HIS118 4.7 253.3 1.0 CD2 B:HIS118 4.8 253.3 1.0 O B:LEU115 4.8 230.2 1.0 CG B:HIS118 4.8 253.3 1.0 SG B:CYS134 4.8 285.0 1.0 SG B:CYS190 4.9 255.1 1.0 SG B:CYS155 4.9 283.2 1.0

Iron binding site 2 out of 4 in the Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:301.3 occ:1.00 FE2 B:SF41000 0.0 301.3 1.0 SG B:CYS155 2.3 283.2 1.0 S1 B:SF41000 2.3 301.3 1.0 S4 B:SF41000 2.3 301.3 1.0 S3 B:SF41000 2.3 301.3 1.0 FE3 B:SF41000 2.7 301.3 1.0 FE4 B:SF41000 2.7 301.3 1.0 FE1 B:SF41000 2.7 301.3 1.0 CB B:CYS155 3.6 283.2 1.0 S2 B:SF41000 3.9 301.3 1.0 CD2 B:PHE157 4.1 259.4 1.0 CD2 B:HIS118 4.1 253.3 1.0 NE2 B:HIS118 4.3 253.3 1.0 CG2 B:THR138 4.7 291.4 1.0 CB B:PHE157 4.7 259.4 1.0 CG B:HIS118 4.7 253.3 1.0 CG B:PHE157 4.8 259.4 1.0 SG B:CYS134 4.8 285.0 1.0 SG B:CYS190 4.8 255.1 1.0 CE2 B:PHE157 4.8 259.4 1.0 SG B:CYS116 4.8 244.5 1.0 CB B:CYS190 4.8 255.1 1.0 CA B:CYS155 4.9 283.2 1.0 CE1 B:HIS118 5.0 253.3 1.0

Iron binding site 3 out of 4 in the Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:301.3 occ:1.00 FE3 B:SF41000 0.0 301.3 1.0 SG B:CYS134 2.3 285.0 1.0 S1 B:SF41000 2.3 301.3 1.0 S2 B:SF41000 2.3 301.3 1.0 S4 B:SF41000 2.3 301.3 1.0 FE4 B:SF41000 2.7 301.3 1.0 FE1 B:SF41000 2.7 301.3 1.0 FE2 B:SF41000 2.7 301.3 1.0 CB B:CYS134 3.2 285.0 1.0 S3 B:SF41000 3.9 301.3 1.0 CA B:CYS134 3.9 285.0 1.0 O B:CYS134 4.6 285.0 1.0 SG B:CYS190 4.6 255.1 1.0 C B:CYS134 4.6 285.0 1.0 CG2 B:THR138 4.6 291.4 1.0 SG B:CYS155 4.7 283.2 1.0 SG B:CYS116 4.7 244.5 1.0

Iron binding site 4 out of 4 in the Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Xpa Repositioning CORE7 of Tfiih Relative to Xpc-Dna Lesion (Ap) within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:301.3 occ:1.00 FE4 B:SF41000 0.0 301.3 1.0 SG B:CYS190 2.3 255.1 1.0 S2 B:SF41000 2.3 301.3 1.0 S1 B:SF41000 2.3 301.3 1.0 S3 B:SF41000 2.3 301.3 1.0 FE3 B:SF41000 2.7 301.3 1.0 FE1 B:SF41000 2.7 301.3 1.0 FE2 B:SF41000 2.7 301.3 1.0 CB B:CYS190 3.1 255.1 1.0 S4 B:SF41000 3.9 301.3 1.0 CA B:CYS190 4.0 255.1 1.0 SG B:CYS134 4.6 285.0 1.0 SG B:CYS155 4.7 283.2 1.0 CD B:PRO191 4.7 240.8 1.0 SG B:CYS116 4.7 244.5 1.0 C B:CYS190 4.8 255.1 1.0 CE2 B:PHE193 4.8 240.8 1.0 O B:LEU115 4.9 230.2 1.0

J.Kim, C.L.Li, X.Chen, Y.Cui, F.M.Golebiowski, H.Wang, F.Hanaoka, K.Sugasawa, W.Yang. Lesion Recognition By Xpc, Tfiih and Xpa in Dna Excision Repair Nature 2023.
ISSN: ESSN 1476-4687