Iron in PDB 8fay: Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
Enzymatic activity of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
All present enzymatic activity of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G):
3.2.2.31;
Protein crystallography data
The structure of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G), PDB code: 8fay
was solved by
C.H.Trasvina-Arenas,
W.J.Lin,
M.Demir,
A.J.Fisher,
S.S.David,
M.P.Horvath,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
60.28 /
1.91
|
|
Space group
|
P 21 21 21
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
87.686,
116.422,
118.378,
90,
90,
90
|
|
R / Rfree (%)
|
18.1 /
20.9
|
Iron Binding Sites:
The binding sites of Iron atom in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
(pdb code 8fay). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the
Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G), PDB code: 8fay:
Jump to Iron binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Iron binding site 1 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 1 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe601
b:33.0
occ:1.00
|
FE1
|
A:SF4601
|
0.0
|
33.0
|
1.0
|
|
SG
|
A:CYS300
|
2.2
|
32.0
|
1.0
|
|
S4
|
A:SF4601
|
2.3
|
36.2
|
1.0
|
|
S2
|
A:SF4601
|
2.3
|
34.5
|
1.0
|
|
S3
|
A:SF4601
|
2.4
|
33.2
|
1.0
|
|
FE3
|
A:SF4601
|
2.7
|
34.5
|
1.0
|
|
FE2
|
A:SF4601
|
2.7
|
33.5
|
1.0
|
|
FE4
|
A:SF4601
|
2.8
|
34.0
|
1.0
|
|
HB2
|
A:CYS300
|
3.1
|
41.7
|
1.0
|
|
CB
|
A:CYS300
|
3.1
|
34.7
|
1.0
|
|
HB3
|
A:CYS300
|
3.2
|
41.7
|
1.0
|
|
HA
|
A:CYS297
|
3.6
|
39.4
|
1.0
|
|
HG23
|
A:VAL302
|
3.6
|
47.9
|
1.0
|
|
HB2
|
A:CYS290
|
3.9
|
43.1
|
1.0
|
|
S1
|
A:SF4601
|
3.9
|
33.1
|
1.0
|
|
HA
|
A:GLU303
|
4.0
|
41.6
|
1.0
|
|
HG22
|
A:VAL302
|
4.0
|
47.9
|
1.0
|
|
HG12
|
A:VAL289
|
4.1
|
38.4
|
1.0
|
|
HD21
|
A:LEU285
|
4.2
|
44.4
|
1.0
|
|
HB2
|
A:CYS306
|
4.3
|
44.2
|
1.0
|
|
CG2
|
A:VAL302
|
4.3
|
39.9
|
1.0
|
|
H
|
A:VAL302
|
4.5
|
39.2
|
1.0
|
|
CA
|
A:CYS297
|
4.5
|
32.8
|
1.0
|
|
HB2
|
A:GLU303
|
4.6
|
47.0
|
1.0
|
|
CA
|
A:CYS300
|
4.6
|
36.3
|
1.0
|
|
HD11
|
A:LEU285
|
4.6
|
45.3
|
1.0
|
|
HB3
|
A:CYS297
|
4.6
|
37.2
|
1.0
|
|
CB
|
A:CYS290
|
4.7
|
35.9
|
1.0
|
|
N
|
A:GLU303
|
4.7
|
37.2
|
1.0
|
|
SG
|
A:CYS290
|
4.7
|
32.2
|
1.0
|
|
CA
|
A:GLU303
|
4.7
|
34.7
|
1.0
|
|
HG21
|
A:VAL302
|
4.7
|
47.9
|
1.0
|
|
HB3
|
A:CYS306
|
4.8
|
44.2
|
1.0
|
|
H
|
A:GLU303
|
4.8
|
44.6
|
1.0
|
|
CB
|
A:CYS306
|
4.8
|
36.8
|
1.0
|
|
SG
|
A:CYS297
|
4.9
|
33.1
|
1.0
|
|
HA
|
A:CYS300
|
4.9
|
43.6
|
1.0
|
|
SG
|
A:CYS306
|
4.9
|
33.2
|
1.0
|
|
HG11
|
A:VAL289
|
4.9
|
38.4
|
1.0
|
|
CB
|
A:CYS297
|
4.9
|
31.0
|
1.0
|
|
CG1
|
A:VAL289
|
4.9
|
32.0
|
1.0
|
|
C
|
A:VAL302
|
4.9
|
34.9
|
1.0
|
|
HA
|
A:CYS290
|
5.0
|
38.3
|
1.0
|
|
Iron binding site 2 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 2 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe601
b:33.5
occ:1.00
|
FE2
|
A:SF4601
|
0.0
|
33.5
|
1.0
|
|
S1
|
A:SF4601
|
2.2
|
33.1
|
1.0
|
|
SG
|
A:CYS290
|
2.3
|
32.2
|
1.0
|
|
S3
|
A:SF4601
|
2.3
|
33.2
|
1.0
|
|
S4
|
A:SF4601
|
2.3
|
36.2
|
1.0
|
|
FE4
|
A:SF4601
|
2.7
|
34.0
|
1.0
|
|
FE3
|
A:SF4601
|
2.7
|
34.5
|
1.0
|
|
FE1
|
A:SF4601
|
2.7
|
33.0
|
1.0
|
|
HB2
|
A:CYS290
|
2.8
|
43.1
|
1.0
|
|
CB
|
A:CYS290
|
3.1
|
35.9
|
1.0
|
|
HD3
|
A:ARG245
|
3.4
|
44.0
|
1.0
|
|
HA
|
A:CYS290
|
3.5
|
38.3
|
1.0
|
|
HH11
|
A:ARG245
|
3.7
|
41.3
|
1.0
|
|
CA
|
A:CYS290
|
3.9
|
31.9
|
1.0
|
|
S2
|
A:SF4601
|
3.9
|
34.5
|
1.0
|
|
HD2
|
A:ARG245
|
3.9
|
44.0
|
1.0
|
|
HB3
|
A:CYS290
|
3.9
|
43.1
|
1.0
|
|
HB2
|
A:ARG245
|
4.0
|
45.4
|
1.0
|
|
CD
|
A:ARG245
|
4.1
|
36.7
|
1.0
|
|
HB3
|
A:ARG245
|
4.2
|
45.4
|
1.0
|
|
HB2
|
A:PRO295
|
4.2
|
44.7
|
1.0
|
|
HA
|
A:VAL242
|
4.4
|
40.2
|
1.0
|
|
NH1
|
A:ARG245
|
4.5
|
34.4
|
1.0
|
|
CB
|
A:ARG245
|
4.5
|
37.8
|
1.0
|
|
HG22
|
A:VAL242
|
4.6
|
43.1
|
1.0
|
|
HB3
|
A:PRO295
|
4.7
|
44.7
|
1.0
|
|
SG
|
A:CYS300
|
4.7
|
32.0
|
1.0
|
|
HG21
|
A:VAL355
|
4.7
|
43.1
|
1.0
|
|
SG
|
A:CYS306
|
4.8
|
33.2
|
1.0
|
|
HG12
|
A:VAL289
|
4.8
|
38.4
|
1.0
|
|
N
|
A:CYS290
|
4.9
|
32.6
|
1.0
|
|
SG
|
A:CYS297
|
4.9
|
33.1
|
1.0
|
|
CB
|
A:PRO295
|
4.9
|
37.2
|
1.0
|
|
C
|
A:CYS290
|
4.9
|
33.4
|
1.0
|
|
HG23
|
A:VAL246
|
4.9
|
47.0
|
1.0
|
|
HH12
|
A:ARG245
|
4.9
|
41.3
|
1.0
|
|
CG
|
A:ARG245
|
5.0
|
37.0
|
1.0
|
|
HG13
|
A:VAL242
|
5.0
|
40.4
|
1.0
|
|
HD21
|
A:LEU285
|
5.0
|
44.4
|
1.0
|
|
Iron binding site 3 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 3 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe601
b:34.5
occ:1.00
|
FE3
|
A:SF4601
|
0.0
|
34.5
|
1.0
|
|
S2
|
A:SF4601
|
2.3
|
34.5
|
1.0
|
|
S4
|
A:SF4601
|
2.3
|
36.2
|
1.0
|
|
S1
|
A:SF4601
|
2.3
|
33.1
|
1.0
|
|
SG
|
A:CYS306
|
2.4
|
33.2
|
1.0
|
|
FE1
|
A:SF4601
|
2.7
|
33.0
|
1.0
|
|
FE2
|
A:SF4601
|
2.7
|
33.5
|
1.0
|
|
FE4
|
A:SF4601
|
2.8
|
34.0
|
1.0
|
|
HB2
|
A:CYS306
|
2.9
|
44.2
|
1.0
|
|
CB
|
A:CYS306
|
3.1
|
36.8
|
1.0
|
|
HB3
|
A:CYS306
|
3.2
|
44.2
|
1.0
|
|
HB2
|
A:ARG309
|
3.4
|
46.6
|
1.0
|
|
S3
|
A:SF4601
|
3.9
|
33.2
|
1.0
|
|
HB3
|
A:ARG245
|
3.9
|
45.4
|
1.0
|
|
H
|
A:ARG309
|
4.0
|
46.6
|
1.0
|
|
HG22
|
A:VAL246
|
4.1
|
47.0
|
1.0
|
|
CB
|
A:ARG309
|
4.2
|
38.8
|
1.0
|
|
HB3
|
A:ARG309
|
4.2
|
46.6
|
1.0
|
|
HA
|
A:GLU303
|
4.3
|
41.6
|
1.0
|
|
HG23
|
A:VAL246
|
4.3
|
47.0
|
1.0
|
|
HB2
|
A:ARG245
|
4.4
|
45.4
|
1.0
|
|
HG11
|
A:VAL355
|
4.4
|
44.9
|
1.0
|
|
HG23
|
A:VAL302
|
4.5
|
47.9
|
1.0
|
|
HB3
|
A:ALA308
|
4.5
|
37.0
|
1.0
|
|
CA
|
A:CYS306
|
4.5
|
38.1
|
1.0
|
|
HA
|
A:VAL246
|
4.6
|
48.0
|
1.0
|
|
CB
|
A:ARG245
|
4.6
|
37.8
|
1.0
|
|
HD3
|
A:ARG245
|
4.7
|
44.0
|
1.0
|
|
N
|
A:ARG309
|
4.7
|
38.9
|
1.0
|
|
CG2
|
A:VAL246
|
4.7
|
39.2
|
1.0
|
|
SG
|
A:CYS300
|
4.7
|
32.0
|
1.0
|
|
HA
|
A:CYS306
|
4.8
|
45.7
|
1.0
|
|
SG
|
A:CYS290
|
4.8
|
32.2
|
1.0
|
|
SG
|
A:CYS297
|
4.8
|
33.1
|
1.0
|
|
HG2
|
A:ARG309
|
4.9
|
46.5
|
1.0
|
|
HB3
|
A:CYS297
|
4.9
|
37.2
|
1.0
|
|
HB
|
A:VAL355
|
5.0
|
46.6
|
1.0
|
|
Iron binding site 4 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 4 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe601
b:34.0
occ:1.00
|
FE4
|
A:SF4601
|
0.0
|
34.0
|
1.0
|
|
S3
|
A:SF4601
|
2.2
|
33.2
|
1.0
|
|
S1
|
A:SF4601
|
2.3
|
33.1
|
1.0
|
|
S2
|
A:SF4601
|
2.3
|
34.5
|
1.0
|
|
SG
|
A:CYS297
|
2.3
|
33.1
|
1.0
|
|
FE2
|
A:SF4601
|
2.7
|
33.5
|
1.0
|
|
FE3
|
A:SF4601
|
2.8
|
34.5
|
1.0
|
|
FE1
|
A:SF4601
|
2.8
|
33.0
|
1.0
|
|
HA
|
A:CYS297
|
3.0
|
39.4
|
1.0
|
|
HB3
|
A:CYS297
|
3.2
|
37.2
|
1.0
|
|
CB
|
A:CYS297
|
3.2
|
31.0
|
1.0
|
|
CA
|
A:CYS297
|
3.5
|
32.8
|
1.0
|
|
HB2
|
A:PRO295
|
3.6
|
44.7
|
1.0
|
|
HG21
|
A:VAL355
|
3.6
|
43.1
|
1.0
|
|
HG11
|
A:VAL355
|
3.9
|
44.9
|
1.0
|
|
HB2
|
A:ARG309
|
3.9
|
46.6
|
1.0
|
|
S4
|
A:SF4601
|
4.0
|
36.2
|
1.0
|
|
H
|
A:CYS297
|
4.0
|
38.0
|
1.0
|
|
HD3
|
A:ARG309
|
4.1
|
45.3
|
1.0
|
|
HB2
|
A:CYS297
|
4.1
|
37.2
|
1.0
|
|
N
|
A:CYS297
|
4.1
|
31.7
|
1.0
|
|
HB2
|
A:CYS300
|
4.4
|
41.7
|
1.0
|
|
CB
|
A:PRO295
|
4.5
|
37.2
|
1.0
|
|
CG2
|
A:VAL355
|
4.5
|
35.9
|
1.0
|
|
HB3
|
A:CYS300
|
4.5
|
41.7
|
1.0
|
|
HG2
|
A:PRO295
|
4.6
|
40.0
|
1.0
|
|
HA
|
A:CYS290
|
4.7
|
38.3
|
1.0
|
|
CG1
|
A:VAL355
|
4.7
|
37.4
|
1.0
|
|
HD3
|
A:ARG245
|
4.8
|
44.0
|
1.0
|
|
SG
|
A:CYS300
|
4.8
|
32.0
|
1.0
|
|
SG
|
A:CYS290
|
4.8
|
32.2
|
1.0
|
|
CB
|
A:CYS300
|
4.8
|
34.7
|
1.0
|
|
HB3
|
A:PRO295
|
4.8
|
44.7
|
1.0
|
|
HG23
|
A:VAL355
|
4.8
|
43.1
|
1.0
|
|
CB
|
A:ARG309
|
4.8
|
38.8
|
1.0
|
|
SG
|
A:CYS306
|
4.8
|
33.2
|
1.0
|
|
HB
|
A:VAL355
|
4.8
|
46.6
|
1.0
|
|
C
|
A:CYS297
|
4.8
|
37.9
|
1.0
|
|
HB2
|
A:CYS290
|
4.9
|
43.1
|
1.0
|
|
HG3
|
A:PRO295
|
4.9
|
40.0
|
1.0
|
|
O
|
D:HOH799
|
4.9
|
40.5
|
1.0
|
|
CG
|
A:PRO295
|
4.9
|
33.3
|
1.0
|
|
CD
|
A:ARG309
|
5.0
|
37.7
|
1.0
|
|
CB
|
A:VAL355
|
5.0
|
38.8
|
1.0
|
|
Iron binding site 5 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 5 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Fe601
b:32.3
occ:1.00
|
FE1
|
D:SF4601
|
0.0
|
32.3
|
1.0
|
|
S4
|
D:SF4601
|
2.2
|
34.3
|
1.0
|
|
SG
|
D:CYS300
|
2.3
|
32.4
|
1.0
|
|
S3
|
D:SF4601
|
2.3
|
32.6
|
1.0
|
|
S2
|
D:SF4601
|
2.3
|
34.1
|
1.0
|
|
FE2
|
D:SF4601
|
2.6
|
32.0
|
1.0
|
|
FE3
|
D:SF4601
|
2.7
|
32.8
|
1.0
|
|
FE4
|
D:SF4601
|
2.8
|
34.0
|
1.0
|
|
HB2
|
D:CYS300
|
3.0
|
46.5
|
1.0
|
|
CB
|
D:CYS300
|
3.1
|
38.7
|
1.0
|
|
HB3
|
D:CYS300
|
3.2
|
46.5
|
1.0
|
|
HA
|
D:CYS297
|
3.7
|
35.8
|
1.0
|
|
HB2
|
D:CYS290
|
3.8
|
34.5
|
1.0
|
|
S1
|
D:SF4601
|
3.9
|
35.6
|
1.0
|
|
HG23
|
D:VAL302
|
3.9
|
41.2
|
1.0
|
|
HA
|
D:GLU303
|
4.0
|
45.7
|
1.0
|
|
HG12
|
D:VAL289
|
4.1
|
39.8
|
1.0
|
|
HG22
|
D:VAL302
|
4.2
|
41.2
|
1.0
|
|
HD21
|
D:LEU285
|
4.2
|
42.9
|
1.0
|
|
HB2
|
D:CYS306
|
4.4
|
36.2
|
1.0
|
|
CG2
|
D:VAL302
|
4.5
|
34.4
|
1.0
|
|
CA
|
D:CYS300
|
4.5
|
32.7
|
1.0
|
|
CB
|
D:CYS290
|
4.6
|
28.8
|
1.0
|
|
H
|
D:VAL302
|
4.6
|
41.9
|
1.0
|
|
CA
|
D:CYS297
|
4.6
|
29.8
|
1.0
|
|
SG
|
D:CYS290
|
4.7
|
31.8
|
1.0
|
|
N
|
D:GLU303
|
4.8
|
41.5
|
1.0
|
|
HA
|
D:CYS300
|
4.8
|
39.2
|
1.0
|
|
CA
|
D:GLU303
|
4.8
|
38.1
|
1.0
|
|
HD11
|
D:LEU285
|
4.8
|
45.9
|
1.0
|
|
HA
|
D:CYS290
|
4.8
|
36.5
|
1.0
|
|
HG11
|
D:VAL289
|
4.9
|
39.8
|
1.0
|
|
CG1
|
D:VAL289
|
4.9
|
33.2
|
1.0
|
|
SG
|
D:CYS306
|
4.9
|
35.8
|
1.0
|
|
HB3
|
D:CYS306
|
4.9
|
36.2
|
1.0
|
|
SG
|
D:CYS297
|
4.9
|
32.2
|
1.0
|
|
HB2
|
D:GLU303
|
4.9
|
42.7
|
1.0
|
|
CB
|
D:CYS306
|
4.9
|
30.1
|
1.0
|
|
H
|
D:GLU303
|
4.9
|
49.9
|
1.0
|
|
HG21
|
D:VAL302
|
5.0
|
41.2
|
1.0
|
|
C
|
D:VAL302
|
5.0
|
34.9
|
1.0
|
|
HB3
|
D:CYS297
|
5.0
|
36.3
|
1.0
|
|
HD2
|
D:PRO301
|
5.0
|
41.0
|
1.0
|
|
Iron binding site 6 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 6 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Fe601
b:32.0
occ:1.00
|
FE2
|
D:SF4601
|
0.0
|
32.0
|
1.0
|
|
S4
|
D:SF4601
|
2.2
|
34.3
|
1.0
|
|
S3
|
D:SF4601
|
2.3
|
32.6
|
1.0
|
|
SG
|
D:CYS290
|
2.3
|
31.8
|
1.0
|
|
S1
|
D:SF4601
|
2.4
|
35.6
|
1.0
|
|
FE1
|
D:SF4601
|
2.6
|
32.3
|
1.0
|
|
FE3
|
D:SF4601
|
2.7
|
32.8
|
1.0
|
|
HB2
|
D:CYS290
|
2.7
|
34.5
|
1.0
|
|
FE4
|
D:SF4601
|
2.8
|
34.0
|
1.0
|
|
CB
|
D:CYS290
|
3.0
|
28.8
|
1.0
|
|
HA
|
D:CYS290
|
3.4
|
36.5
|
1.0
|
|
HD3
|
D:ARG245
|
3.5
|
47.4
|
1.0
|
|
HH11
|
D:ARG245
|
3.7
|
37.4
|
1.0
|
|
CA
|
D:CYS290
|
3.8
|
30.4
|
1.0
|
|
S2
|
D:SF4601
|
3.8
|
34.1
|
1.0
|
|
HB3
|
D:CYS290
|
3.8
|
34.5
|
1.0
|
|
HD2
|
D:ARG245
|
4.0
|
47.4
|
1.0
|
|
HB2
|
D:ARG245
|
4.2
|
37.9
|
1.0
|
|
CD
|
D:ARG245
|
4.2
|
39.5
|
1.0
|
|
HB2
|
D:PRO295
|
4.2
|
44.2
|
1.0
|
|
HB3
|
D:ARG245
|
4.3
|
37.9
|
1.0
|
|
HA
|
D:VAL242
|
4.4
|
37.1
|
1.0
|
|
NH1
|
D:ARG245
|
4.5
|
31.2
|
1.0
|
|
CB
|
D:ARG245
|
4.6
|
31.6
|
1.0
|
|
SG
|
D:CYS300
|
4.6
|
32.4
|
1.0
|
|
HG22
|
D:VAL242
|
4.7
|
38.8
|
1.0
|
|
HG23
|
D:VAL246
|
4.7
|
47.5
|
1.0
|
|
HG12
|
D:VAL289
|
4.7
|
39.8
|
1.0
|
|
HB3
|
D:PRO295
|
4.7
|
44.2
|
1.0
|
|
N
|
D:CYS290
|
4.7
|
33.2
|
1.0
|
|
HG21
|
D:VAL355
|
4.8
|
45.1
|
1.0
|
|
SG
|
D:CYS306
|
4.8
|
35.8
|
1.0
|
|
C
|
D:CYS290
|
4.9
|
32.1
|
1.0
|
|
HD21
|
D:LEU285
|
4.9
|
42.9
|
1.0
|
|
SG
|
D:CYS297
|
4.9
|
32.2
|
1.0
|
|
CB
|
D:PRO295
|
4.9
|
36.8
|
1.0
|
|
HH12
|
D:ARG245
|
4.9
|
37.4
|
1.0
|
|
HG13
|
D:VAL242
|
4.9
|
38.7
|
1.0
|
|
HB2
|
D:CYS300
|
5.0
|
46.5
|
1.0
|
|
HA
|
D:CYS297
|
5.0
|
35.8
|
1.0
|
|
Iron binding site 7 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 7 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 7 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Fe601
b:32.8
occ:1.00
|
FE3
|
D:SF4601
|
0.0
|
32.8
|
1.0
|
|
S2
|
D:SF4601
|
2.2
|
34.1
|
1.0
|
|
S1
|
D:SF4601
|
2.3
|
35.6
|
1.0
|
|
S4
|
D:SF4601
|
2.3
|
34.3
|
1.0
|
|
SG
|
D:CYS306
|
2.4
|
35.8
|
1.0
|
|
FE1
|
D:SF4601
|
2.7
|
32.3
|
1.0
|
|
FE2
|
D:SF4601
|
2.7
|
32.0
|
1.0
|
|
FE4
|
D:SF4601
|
2.7
|
34.0
|
1.0
|
|
HB2
|
D:CYS306
|
3.0
|
36.2
|
1.0
|
|
CB
|
D:CYS306
|
3.2
|
30.1
|
1.0
|
|
HB3
|
D:CYS306
|
3.3
|
36.2
|
1.0
|
|
HB2
|
D:ARG309
|
3.4
|
36.6
|
1.0
|
|
HB3
|
D:ARG245
|
3.8
|
37.9
|
1.0
|
|
S3
|
D:SF4601
|
3.9
|
32.6
|
1.0
|
|
HG22
|
D:VAL246
|
4.0
|
47.5
|
1.0
|
|
HG23
|
D:VAL246
|
4.0
|
47.5
|
1.0
|
|
HB3
|
D:ARG309
|
4.1
|
36.6
|
1.0
|
|
H
|
D:ARG309
|
4.1
|
43.3
|
1.0
|
|
CB
|
D:ARG309
|
4.2
|
30.5
|
1.0
|
|
HG11
|
D:VAL355
|
4.3
|
40.5
|
1.0
|
|
HA
|
D:GLU303
|
4.4
|
45.7
|
1.0
|
|
HB2
|
D:ARG245
|
4.4
|
37.9
|
1.0
|
|
CG2
|
D:VAL246
|
4.5
|
39.5
|
1.0
|
|
HB3
|
D:ALA308
|
4.5
|
46.5
|
1.0
|
|
CB
|
D:ARG245
|
4.6
|
31.6
|
1.0
|
|
HD3
|
D:ARG245
|
4.6
|
47.4
|
1.0
|
|
CA
|
D:CYS306
|
4.6
|
36.3
|
1.0
|
|
HG23
|
D:VAL302
|
4.7
|
41.2
|
1.0
|
|
HA
|
D:VAL246
|
4.7
|
38.3
|
1.0
|
|
SG
|
D:CYS300
|
4.8
|
32.4
|
1.0
|
|
SG
|
D:CYS290
|
4.8
|
31.8
|
1.0
|
|
SG
|
D:CYS297
|
4.8
|
32.2
|
1.0
|
|
N
|
D:ARG309
|
4.8
|
36.1
|
1.0
|
|
HG2
|
D:ARG309
|
4.8
|
41.8
|
1.0
|
|
HA
|
D:CYS306
|
4.9
|
43.6
|
1.0
|
|
HB
|
D:VAL355
|
4.9
|
49.8
|
1.0
|
|
Iron binding site 8 out
of 8 in 8fay
Go back to
Iron Binding Sites List in 8fay
Iron binding site 8 out
of 8 in the Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G)
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 8 of Human Mutyh Adenine Glycosylase Bound to Dna Containing A Transition State Analog (1N) Paired with D(8-Oxo-G) within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Fe601
b:34.0
occ:1.00
|
FE4
|
D:SF4601
|
0.0
|
34.0
|
1.0
|
|
S1
|
D:SF4601
|
2.2
|
35.6
|
1.0
|
|
S2
|
D:SF4601
|
2.3
|
34.1
|
1.0
|
|
SG
|
D:CYS297
|
2.3
|
32.2
|
1.0
|
|
S3
|
D:SF4601
|
2.3
|
32.6
|
1.0
|
|
FE3
|
D:SF4601
|
2.7
|
32.8
|
1.0
|
|
FE2
|
D:SF4601
|
2.8
|
32.0
|
1.0
|
|
FE1
|
D:SF4601
|
2.8
|
32.3
|
1.0
|
|
HA
|
D:CYS297
|
2.9
|
35.8
|
1.0
|
|
CB
|
D:CYS297
|
3.3
|
30.2
|
1.0
|
|
HB3
|
D:CYS297
|
3.3
|
36.3
|
1.0
|
|
CA
|
D:CYS297
|
3.5
|
29.8
|
1.0
|
|
HG21
|
D:VAL355
|
3.6
|
45.1
|
1.0
|
|
HB2
|
D:PRO295
|
3.7
|
44.2
|
1.0
|
|
HG11
|
D:VAL355
|
3.7
|
40.5
|
1.0
|
|
HB2
|
D:ARG309
|
3.8
|
36.6
|
1.0
|
|
S4
|
D:SF4601
|
4.0
|
34.3
|
1.0
|
|
H
|
D:CYS297
|
4.0
|
35.4
|
1.0
|
|
N
|
D:CYS297
|
4.1
|
29.5
|
1.0
|
|
HB2
|
D:CYS297
|
4.1
|
36.3
|
1.0
|
|
HD3
|
D:ARG309
|
4.3
|
45.2
|
1.0
|
|
HB2
|
D:CYS300
|
4.3
|
46.5
|
1.0
|
|
HG2
|
D:PRO295
|
4.5
|
46.1
|
1.0
|
|
CG2
|
D:VAL355
|
4.5
|
37.6
|
1.0
|
|
HB3
|
D:CYS300
|
4.5
|
46.5
|
1.0
|
|
CB
|
D:PRO295
|
4.6
|
36.8
|
1.0
|
|
CG1
|
D:VAL355
|
4.6
|
33.8
|
1.0
|
|
HA
|
D:CYS290
|
4.7
|
36.5
|
1.0
|
|
CB
|
D:ARG309
|
4.7
|
30.5
|
1.0
|
|
HB
|
D:VAL355
|
4.7
|
49.8
|
1.0
|
|
CB
|
D:CYS300
|
4.7
|
38.7
|
1.0
|
|
HD3
|
D:ARG245
|
4.8
|
47.4
|
1.0
|
|
C
|
D:CYS297
|
4.8
|
33.6
|
1.0
|
|
SG
|
D:CYS290
|
4.8
|
31.8
|
1.0
|
|
HG2
|
D:ARG309
|
4.8
|
41.8
|
1.0
|
|
SG
|
D:CYS300
|
4.8
|
32.4
|
1.0
|
|
SG
|
D:CYS306
|
4.8
|
35.8
|
1.0
|
|
HG23
|
D:VAL355
|
4.8
|
45.1
|
1.0
|
|
CG
|
D:PRO295
|
4.9
|
38.4
|
1.0
|
|
HG3
|
D:PRO295
|
4.9
|
46.1
|
1.0
|
|
CB
|
D:VAL355
|
4.9
|
41.5
|
1.0
|
|
HB3
|
D:PRO295
|
4.9
|
44.2
|
1.0
|
|
HB2
|
D:CYS290
|
4.9
|
34.5
|
1.0
|
|
Reference:
C.H.Trasvina-Arenas,
C.H.Trasvina-Arenas,
W.J.Lin,
M.Demir,
A.J.Fisher,
S.S.David,
M.P.Horvath.
N/A N/A.
Page generated: Sat Aug 10 03:35:29 2024
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