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Atomistry » Iron » PDB 8f4g-8fgj » 8fge » |
Iron in PDB 8fge: Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine DihydrochlorideEnzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride
All present enzymatic activity of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride:
1.14.13.39; Protein crystallography data
The structure of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride, PDB code: 8fge
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8fge:
The structure of Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride
(pdb code 8fge). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride, PDB code: 8fge: Iron binding site 1 out of 1 in 8fgeGo back to Iron Binding Sites List in 8fge
Iron binding site 1 out
of 1 in the Structure of Rat Neuronal Nitric Oxide Synthase R349A Mutant Heme Domain in Complex with 4-(Difluoromethyl)-6-(5-(2-(Dimethylamino) Ethyl)-2,3-Difluorophenethyl)Pyridin-2-Amine Dihydrochloride
Mono view Stereo pair view
Reference:
D.Vasu,
H.T.Do,
H.Li,
C.D.Hardy,
A.Awasthi,
T.L.Poulos,
R.B.Silverman.
Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. J.Med.Chem. V. 66 9934 2023.
Page generated: Thu Dec 28 05:57:45 2023
ISSN: ISSN 0022-2623 PubMed: 37433128 DOI: 10.1021/ACS.JMEDCHEM.3C00782 |
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