Iron in PDB 8ghb: The Structure of H12-Lox in Monomeric Form

All present enzymatic activity of The Structure of H12-Lox in Monomeric Form:
1.13.11.31; 1.13.11.33;

The binding sites of Iron atom in the The Structure of H12-Lox in Monomeric Form (pdb code 8ghb). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the The Structure of H12-Lox in Monomeric Form, PDB code: 8ghb:

Iron binding site 1 out of 1 in the The Structure of H12-Lox in Monomeric Form


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of The Structure of H12-Lox in Monomeric Form within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe901 b:121.5 occ:1.00 OXT A:ILE663 2.1 113.3 1.0 NE2 A:HIS360 2.2 96.0 1.0 NE2 A:HIS365 2.2 91.4 1.0 O A:ILE663 2.6 122.2 1.0 C A:ILE663 2.7 118.6 1.0 OD1 A:ASN544 2.7 109.0 1.0 NE2 A:HIS540 2.8 86.3 1.0 CE1 A:HIS360 2.9 93.2 1.0 CE1 A:HIS365 3.1 90.0 1.0 CD2 A:HIS365 3.2 89.7 1.0 CD2 A:HIS360 3.3 93.1 1.0 CG A:ASN544 3.4 107.3 1.0 CD2 A:HIS540 3.5 78.0 1.0 CE1 A:HIS540 3.9 93.7 1.0 CB A:ASN544 4.1 100.8 1.0 ND1 A:HIS360 4.1 87.6 1.0 ND2 A:ASN544 4.2 101.3 1.0 CA A:ILE663 4.2 117.0 1.0 ND1 A:HIS365 4.3 84.8 1.0 CG A:HIS360 4.3 85.4 1.0 CG A:HIS365 4.3 91.1 1.0 N A:ILE663 4.7 116.4 1.0 CG2 A:ILE663 4.8 113.0 1.0 CG A:HIS540 4.8 85.9 1.0 CG1 A:VAL661 4.9 94.1 1.0 O A:LEU597 4.9 116.6 1.0 ND1 A:HIS540 5.0 94.4 1.0 OE1 A:GLN547 5.0 109.1 1.0

J.I.Mobbs, K.A.Black, M.Tran, W.A.C.Burger, H.Venugopal, T.R.Holman, M.Holinstat, D.Thal, A.Glukhova. Cryo-Em Structures of Human Arachidonate 12S-Lipoxygenase (12-Lox) Bound to Endogenous and Exogenous Inhibitors. Blood 2023.
ISSN: ESSN 1528-0020
PubMed: 37506345
DOI: 10.1182/BLOOD.2023020441