Iron in PDB 8olt: Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A

All present enzymatic activity of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A:
7.1.1.2;

The structure of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	1 atom
Sodium	(Na)	1 atom

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 28;

Binding sites:

The binding sites of Iron atom in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A (pdb code 8olt). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 28 binding sites of Iron where determined in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A, PDB code: 8olt:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.4 occ:1.00 FE1 B:SF4201 0.0 31.4 1.0 SG B:CYS129 2.2 29.2 1.0 S2 B:SF4201 2.3 31.4 1.0 S4 B:SF4201 2.3 31.4 1.0 S3 B:SF4201 2.3 31.4 1.0 FE4 B:SF4201 2.7 31.4 1.0 FE3 B:SF4201 2.7 31.4 1.0 FE2 B:SF4201 2.7 31.4 1.0 CB B:CYS129 3.1 29.2 1.0 O B:HOH318 3.5 28.1 1.0 S1 B:SF4201 3.9 31.4 1.0 N B:CYS129 3.9 29.2 1.0 O B:HOH320 4.0 28.9 1.0 OG1 B:THR101 4.1 31.2 1.0 CA B:CYS129 4.1 29.2 1.0 CQ2 D:2MR85 4.5 31.5 1.0 CE2 B:TYR136 4.6 29.3 1.0 SG B:CYS159 4.6 29.5 1.0 SG B:CYS64 4.8 31.6 1.0 SG B:CYS65 4.9 31.8 1.0 N B:THR101 4.9 31.2 1.0 NH2 D:2MR85 5.0 31.5 1.0

Iron binding site 2 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.4 occ:1.00 FE2 B:SF4201 0.0 31.4 1.0 S3 B:SF4201 2.3 31.4 1.0 S1 B:SF4201 2.3 31.4 1.0 S4 B:SF4201 2.3 31.4 1.0 SG B:CYS65 2.3 31.8 1.0 FE3 B:SF4201 2.7 31.4 1.0 FE4 B:SF4201 2.7 31.4 1.0 FE1 B:SF4201 2.7 31.4 1.0 CB B:CYS65 3.3 31.8 1.0 O B:HOH320 3.7 28.9 1.0 N B:CYS65 3.7 31.8 1.0 CA B:CYS65 3.9 31.8 1.0 S2 B:SF4201 3.9 31.4 1.0 CA B:PRO160 4.2 31.5 1.0 CB B:PRO160 4.4 31.5 1.0 CA B:GLY127 4.5 29.4 1.0 CA B:CYS159 4.5 29.5 1.0 N B:PRO160 4.6 31.5 1.0 C B:CYS64 4.6 31.6 1.0 SG B:CYS64 4.7 31.6 1.0 SG B:CYS129 4.8 29.2 1.0 SG B:CYS159 4.8 29.5 1.0 C B:CYS159 4.8 29.5 1.0 O B:GLY158 4.8 29.6 1.0 N B:SER128 4.9 28.4 1.0 CB B:CYS64 4.9 31.6 1.0 CB B:CYS129 4.9 29.2 1.0 CA B:GLY100 5.0 30.9 1.0

Iron binding site 3 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.4 occ:1.00 FE3 B:SF4201 0.0 31.4 1.0 SG B:CYS64 2.3 31.6 1.0 S4 B:SF4201 2.3 31.4 1.0 S2 B:SF4201 2.3 31.4 1.0 S1 B:SF4201 2.3 31.4 1.0 FE1 B:SF4201 2.7 31.4 1.0 FE4 B:SF4201 2.7 31.4 1.0 FE2 B:SF4201 2.7 31.4 1.0 CB B:CYS64 3.2 31.6 1.0 CQ2 D:2MR85 3.7 31.5 1.0 NE2 D:HIS190 3.8 31.9 1.0 N B:CYS64 3.9 31.6 1.0 S3 B:SF4201 3.9 31.4 1.0 CA B:CYS64 4.0 31.6 1.0 N B:CYS65 4.0 31.8 1.0 C B:CYS64 4.3 31.6 1.0 CG D:ARG105 4.5 30.3 1.0 CD2 D:HIS190 4.6 31.9 1.0 SG B:CYS129 4.7 29.2 1.0 CB B:ALA63 4.7 32.3 1.0 SG B:CYS65 4.8 31.8 1.0 SG B:CYS159 4.8 29.5 1.0 CE1 D:HIS190 4.9 31.9 1.0 NH2 D:2MR85 4.9 31.5 1.0 CA B:CYS65 5.0 31.8 1.0 C B:ALA63 5.0 32.3 1.0

Iron binding site 4 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:31.4 occ:1.00 FE4 B:SF4201 0.0 31.4 1.0 SG B:CYS159 2.3 29.5 1.0 S3 B:SF4201 2.3 31.4 1.0 S1 B:SF4201 2.3 31.4 1.0 S2 B:SF4201 2.3 31.4 1.0 FE1 B:SF4201 2.7 31.4 1.0 FE3 B:SF4201 2.7 31.4 1.0 FE2 B:SF4201 2.7 31.4 1.0 CB B:CYS159 3.3 29.5 1.0 CA B:CYS159 3.4 29.5 1.0 C B:CYS159 3.7 29.5 1.0 O B:HOH318 3.7 28.1 1.0 S4 B:SF4201 3.9 31.4 1.0 NE D:ARG105 4.1 30.3 1.0 O B:CYS159 4.1 29.5 1.0 N B:PRO160 4.2 31.5 1.0 CD2 D:HIS190 4.2 31.9 1.0 NE2 D:HIS190 4.3 31.9 1.0 NH1 D:ARG105 4.4 30.3 1.0 CA B:PRO160 4.7 31.5 1.0 CZ D:ARG105 4.7 30.3 1.0 SG B:CYS129 4.7 29.2 1.0 SG B:CYS64 4.8 31.6 1.0 N B:CYS159 4.8 29.5 1.0 SG B:CYS65 4.8 31.8 1.0 CD B:PRO160 4.9 31.5 1.0 CD D:ARG105 4.9 30.3 1.0 O B:GLY158 4.9 29.6 1.0 CG D:ARG105 5.0 30.3 1.0

Iron binding site 5 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:49.6 occ:1.00 FE1 E:FES301 0.0 49.6 1.0 SG E:CYS103 2.2 46.3 1.0 S2 E:FES301 2.2 49.6 1.0 S1 E:FES301 2.2 49.6 1.0 SG E:CYS108 2.3 46.5 1.0 FE2 E:FES301 2.7 49.6 1.0 CB E:CYS103 3.2 46.3 1.0 CB E:CYS108 3.3 46.5 1.0 CA E:CYS144 4.1 45.9 1.0 N E:CYS108 4.2 46.5 1.0 CA E:CYS108 4.3 46.5 1.0 N E:LEU145 4.4 47.5 1.0 SG E:CYS144 4.5 45.9 1.0 CA E:CYS103 4.5 46.3 1.0 CB E:CYS144 4.6 45.9 1.0 C E:CYS103 4.7 46.3 1.0 SG E:CYS148 4.7 47.4 1.0 CA E:CYS148 4.8 47.4 1.0 C E:CYS144 4.8 45.9 1.0 CG E:MET153 4.8 50.2 1.0 SD E:MET153 4.8 50.2 1.0 N E:CYS144 4.9 45.9 1.0 N E:THR105 4.9 44.5 1.0 O E:THR105 5.0 44.5 1.0

Iron binding site 6 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ E:Fe301 b:49.6 occ:1.00 FE2 E:FES301 0.0 49.6 1.0 S1 E:FES301 2.2 49.6 1.0 S2 E:FES301 2.2 49.6 1.0 SG E:CYS144 2.3 45.9 1.0 SG E:CYS148 2.3 47.4 1.0 FE1 E:FES301 2.7 49.6 1.0 CB E:CYS144 3.3 45.9 1.0 CB E:CYS148 3.3 47.4 1.0 CA E:CYS148 3.6 47.4 1.0 CA E:CYS144 3.6 45.9 1.0 N E:CYS148 3.8 47.4 1.0 N E:GLY146 4.1 47.8 1.0 N E:LEU145 4.1 47.5 1.0 C E:CYS144 4.2 45.9 1.0 SG E:CYS103 4.2 46.3 1.0 N E:ALA147 4.3 49.0 1.0 N F:GLY103 4.4 47.2 1.0 SG E:CYS108 4.5 46.5 1.0 C E:ALA147 4.6 49.0 1.0 CB E:PRO107 4.6 45.7 1.0 CA E:GLY146 4.6 47.8 1.0 CG E:PRO107 4.8 45.7 1.0 C E:GLY146 4.8 47.8 1.0 N E:CYS144 4.9 45.9 1.0 CA F:PRO102 4.9 45.1 1.0

Iron binding site 7 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:36.0 occ:1.00 FE1 F:SF4501 0.0 36.0 1.0 S4 F:SF4501 2.3 36.0 1.0 S3 F:SF4501 2.3 36.0 1.0 SG F:CYS362 2.3 33.6 1.0 S2 F:SF4501 2.3 36.0 1.0 FE2 F:SF4501 2.7 36.0 1.0 FE4 F:SF4501 2.7 36.0 1.0 FE3 F:SF4501 2.7 36.0 1.0 CB F:CYS362 3.4 33.6 1.0 N F:CYS362 3.8 33.6 1.0 S1 F:SF4501 3.9 36.0 1.0 CB F:CYS365 4.0 34.4 1.0 CA F:CYS362 4.1 33.6 1.0 N F:ILE404 4.2 34.1 1.0 O F:CYS362 4.3 33.6 1.0 CB F:ILE404 4.4 34.1 1.0 CB F:THR403 4.4 34.6 1.0 SG F:CYS365 4.5 34.4 1.0 N F:CYS405 4.5 36.6 1.0 C F:CYS362 4.6 33.6 1.0 SG F:CYS359 4.7 37.1 1.0 CG2 F:THR403 4.8 34.6 1.0 SG F:CYS405 4.8 36.6 1.0 CA F:ILE404 4.8 34.1 1.0 CG1 F:ILE404 4.9 34.1 1.0 N F:GLN361 4.9 35.4 1.0 C F:GLN361 4.9 35.4 1.0 CB F:GLN361 4.9 35.4 1.0

Iron binding site 8 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:36.0 occ:1.00 FE2 F:SF4501 0.0 36.0 1.0 SG F:CYS365 2.2 34.4 1.0 S4 F:SF4501 2.3 36.0 1.0 S3 F:SF4501 2.3 36.0 1.0 S1 F:SF4501 2.3 36.0 1.0 FE1 F:SF4501 2.7 36.0 1.0 FE3 F:SF4501 2.7 36.0 1.0 FE4 F:SF4501 2.7 36.0 1.0 CB F:CYS365 2.9 34.4 1.0 OG F:SER358 3.2 37.6 1.0 S2 F:SF4501 3.9 36.0 1.0 CD2 F:LEU407 4.2 39.0 1.0 CB F:SER358 4.3 37.6 1.0 N F:CYS359 4.3 37.1 1.0 CA F:CYS365 4.4 34.4 1.0 CA F:SER358 4.5 37.6 1.0 CB F:LEU407 4.6 39.0 1.0 SG F:CYS362 4.6 33.6 1.0 N F:GLY408 4.6 38.0 1.0 SG F:CYS405 4.7 36.6 1.0 C F:CYS365 4.8 34.4 1.0 SG F:CYS359 4.8 37.1 1.0 N F:GLY360 4.8 35.7 1.0 C F:SER358 4.8 37.6 1.0 CG F:LEU407 4.9 39.0 1.0

Iron binding site 9 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:36.0 occ:1.00 FE3 F:SF4501 0.0 36.0 1.0 SG F:CYS405 2.2 36.6 1.0 S4 F:SF4501 2.3 36.0 1.0 S1 F:SF4501 2.3 36.0 1.0 S2 F:SF4501 2.3 36.0 1.0 FE4 F:SF4501 2.7 36.0 1.0 FE2 F:SF4501 2.7 36.0 1.0 FE1 F:SF4501 2.7 36.0 1.0 CB F:CYS405 3.3 36.6 1.0 N F:CYS405 3.8 36.6 1.0 S3 F:SF4501 3.9 36.0 1.0 CA F:CYS405 4.0 36.6 1.0 CB F:LEU407 4.2 39.0 1.0 C F:CYS405 4.2 36.6 1.0 CG F:PRO203 4.2 37.6 1.0 O F:CYS405 4.3 36.6 1.0 CD1 F:ILE185 4.4 40.1 1.0 N F:LEU407 4.6 39.0 1.0 CD F:PRO203 4.7 37.6 1.0 SG F:CYS359 4.7 37.1 1.0 SG F:CYS365 4.8 34.4 1.0 N F:GLY408 4.8 38.0 1.0 SG F:CYS362 4.8 33.6 1.0 CA F:LEU407 4.9 39.0 1.0 N F:ALA406 4.9 38.6 1.0 C F:ILE404 5.0 34.1 1.0

Iron binding site 10 out of 28 in the Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Mitochondrial Complex I From Mus Musculus in the Active State Bound with Piericidin A within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe501 b:36.0 occ:1.00 FE4 F:SF4501 0.0 36.0 1.0 SG F:CYS359 2.3 37.1 1.0 S3 F:SF4501 2.3 36.0 1.0 S1 F:SF4501 2.3 36.0 1.0 S2 F:SF4501 2.3 36.0 1.0 FE3 F:SF4501 2.7 36.0 1.0 FE2 F:SF4501 2.7 36.0 1.0 FE1 F:SF4501 2.7 36.0 1.0 CB F:CYS359 3.3 37.1 1.0 N F:CYS359 3.7 37.1 1.0 N F:GLN361 3.9 35.4 1.0 N F:GLY360 3.9 35.7 1.0 S4 F:SF4501 3.9 36.0 1.0 CA F:CYS359 3.9 37.1 1.0 CB F:GLN361 4.1 35.4 1.0 C F:CYS359 4.2 37.1 1.0 CD F:PRO203 4.3 37.6 1.0 N F:CYS362 4.5 33.6 1.0 OG F:SER358 4.6 37.6 1.0 CA F:GLN361 4.6 35.4 1.0 NE2 F:GLN361 4.6 35.4 1.0 SG F:CYS405 4.7 36.6 1.0 CG F:PRO203 4.7 37.6 1.0 C F:GLY360 4.8 35.7 1.0 SG F:CYS365 4.8 34.4 1.0 C F:SER358 4.8 37.6 1.0 CA F:GLY360 4.8 35.7 1.0 SG F:CYS362 4.8 33.6 1.0

D.N.Grba, I.Chung, H.R.Bridges, A.A.Agip, J.Hirst. Investigation of Hydrated Channels and Proton Pathways in A High-Resolution Cryo-Em Structure of Mammalian Complex I. Sci Adv V. 9 I1359 2023.
ISSN: ESSN 2375-2548
PubMed: 37531432
DOI: 10.1126/SCIADV.ADI1359