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Iron in PDB 8q6e: Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide

Enzymatic activity of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide

All present enzymatic activity of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide:
1.14.11.29;

Protein crystallography data

The structure of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide, PDB code: 8q6e was solved by G.Fiorini, W.D.Figg Jr, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.77 / 1.37
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 130.9, 38.12, 42.77, 90, 90, 90
R / Rfree (%) 18 / 20.5

Other elements in 8q6e:

The structure of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms
Magnesium (Mg) 3 atoms

Iron Binding Sites:

The binding sites of Iron atom in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide (pdb code 8q6e). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide, PDB code: 8q6e:

Iron binding site 1 out of 1 in 8q6e

Go back to Iron Binding Sites List in 8q6e
Iron binding site 1 out of 1 in the Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Aerobic Crystal Structure of Hif Prolyl Hydroxylase 2 (PHD2 181-407) in Complex with Fe(III), 2-Oxoglutarate (2OG) and HIF2ALPHA-Codd Peptide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe506

b:16.1
occ:1.00
O1 A:AKG507 2.0 16.4 1.0
O5 A:AKG507 2.1 16.4 1.0
OD1 A:ASP315 2.1 16.9 1.0
NE2 A:HIS374 2.1 16.0 1.0
NE2 A:HIS313 2.2 17.9 1.0
O A:HOH617 2.2 17.6 1.0
C2 A:AKG507 2.7 15.5 1.0
C1 A:AKG507 2.8 14.6 1.0
CE1 A:HIS313 3.0 18.4 1.0
CD2 A:HIS374 3.1 17.3 1.0
CE1 A:HIS374 3.1 16.1 1.0
CG A:ASP315 3.1 16.8 1.0
HE1 A:HIS313 3.1 22.1 1.0
CD2 A:HIS313 3.2 17.6 1.0
HD2 A:HIS374 3.3 20.7 1.0
HE1 A:HIS374 3.3 19.3 1.0
OD2 A:ASP315 3.5 16.7 1.0
HD2 A:HIS313 3.5 21.1 1.0
HG3 B:PRO531 3.5 25.0 1.0
HZ A:PHE366 3.9 19.9 1.0
O2 A:AKG507 4.0 18.4 1.0
HD3 B:PRO531 4.1 25.3 1.0
C3 A:AKG507 4.1 18.0 1.0
ND1 A:HIS374 4.2 16.2 1.0
ND1 A:HIS313 4.2 17.9 1.0
CG A:HIS374 4.2 16.5 1.0
O A:HOH667 4.2 19.2 1.0
HA A:ASP315 4.3 20.0 1.0
HZ2 A:TRP389 4.3 21.1 1.0
CG A:HIS313 4.3 16.9 1.0
CG B:PRO531 4.4 20.9 1.0
H42 A:AKG507 4.4 21.5 1.0
H32 A:AKG507 4.5 21.7 1.0
CB A:ASP315 4.5 16.5 1.0
H41 A:AKG507 4.5 21.5 1.0
C4 A:AKG507 4.6 17.9 1.0
CD B:PRO531 4.7 21.1 1.0
HE2 A:TYR310 4.7 22.0 1.0
H31 A:AKG507 4.7 21.7 1.0
CE2 A:TYR310 4.8 18.3 1.0
CA A:ASP315 4.8 16.6 1.0
CZ A:PHE366 4.8 16.6 1.0
HG21 A:THR325 4.8 20.1 1.0
HD2 B:PRO531 4.9 25.3 1.0
HE1 A:PHE366 4.9 21.1 1.0
HG2 B:PRO531 4.9 25.0 1.0
HB3 B:PRO531 5.0 25.2 1.0
HD1 A:HIS313 5.0 21.5 1.0
HB2 A:ASP315 5.0 19.8 1.0
HB3 A:ASP315 5.0 19.8 1.0
HD1 A:HIS374 5.0 19.5 1.0
HE1 A:TRP389 5.0 22.5 1.0
CD2 A:TYR310 5.0 19.2 1.0
HD2 A:TYR310 5.0 23.1 1.0

Reference:

G.Fiorini, W.D.Figg Jr, C.J.Schofield. Hif Prolyl Hydroxylase 2 in Complex with HIF2ALPHA-Codd To Be Published.
Page generated: Sat Sep 28 21:39:08 2024

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