Iron in PDB 8rmg: Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation)

All present enzymatic activity of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation):
2.8.1.7;

The binding sites of Iron atom in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation) (pdb code 8rmg). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation), PDB code: 8rmg:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe201 b:117.0 occ:1.00 OD2 D:ASP71 2.1 71.2 1.0 NE2 D:HIS137 2.3 86.0 1.0 SG A:CYS381 2.5 102.8 1.0 CG D:ASP71 2.7 67.9 1.0 SG D:CYS95 2.7 59.4 1.0 OD1 D:ASP71 2.8 66.8 1.0 CD2 D:HIS137 3.2 85.8 1.0 CE1 D:HIS137 3.4 84.5 1.0 CB D:CYS95 3.4 50.4 1.0 CB A:CYS381 3.9 99.3 1.0 SG D:CYS138 4.0 74.9 1.0 CB D:ASP71 4.2 62.9 1.0 N D:CYS95 4.3 52.3 1.0 CG D:HIS137 4.3 85.5 1.0 ND1 D:HIS137 4.4 85.3 1.0 CA D:CYS95 4.5 45.8 1.0 CE D:LYS135 4.8 74.2 1.0 NZ D:LYS135 4.9 75.0 1.0 CB D:ALA98 4.9 43.5 1.0 CA A:CYS381 4.9 100.9 1.0

Iron binding site 2 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:100.2 occ:1.00 FE1 I:FES201 0.0 100.2 1.0 S1 I:FES201 2.2 99.9 1.0 S2 I:FES201 2.2 104.8 1.0 SG I:CYS114 2.3 107.8 1.0 SG I:CYS108 2.3 127.0 1.0 FE2 I:FES201 3.1 101.1 1.0 CB I:CYS108 3.3 126.7 1.0 CB I:CYS114 3.5 106.5 1.0 N I:SER115 3.5 99.5 1.0 N I:CYS114 3.6 105.9 1.0 N I:CYS108 3.8 127.7 1.0 CA I:CYS114 3.9 106.4 1.0 CA I:CYS108 4.1 127.9 1.0 SG I:CYS117 4.1 100.9 1.0 C I:CYS114 4.1 107.6 1.0 N I:ALA113 4.2 104.4 1.0 N I:THR116 4.4 96.6 1.0 N I:GLU109 4.5 129.2 1.0 CA I:SER115 4.5 98.3 1.0 N I:LEU112 4.5 97.8 1.0 C I:CYS108 4.5 128.3 1.0 N I:ALA107 4.7 120.3 1.0 C I:ALA113 4.7 104.6 1.0 N I:ALA110 4.7 121.5 1.0 C I:GLY106 4.7 114.5 1.0 CA I:LEU112 4.8 95.9 1.0 CA I:GLY106 4.8 113.3 1.0 N I:CYS117 4.9 98.2 1.0 N I:SER111 5.0 122.4 1.0 C I:LEU112 5.0 96.0 1.0 C I:SER115 5.0 97.2 1.0

Iron binding site 3 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:101.1 occ:1.00 FE2 I:FES201 0.0 101.1 1.0 S2 I:FES201 2.2 104.8 1.0 S1 I:FES201 2.2 99.9 1.0 SG I:CYS154 2.3 100.9 1.0 SG I:CYS117 2.3 100.9 1.0 CB I:CYS154 2.7 100.2 1.0 FE1 I:FES201 3.1 100.2 1.0 CB I:CYS117 3.5 97.9 1.0 CA I:CYS154 3.9 101.2 1.0 N I:CYS154 3.9 102.0 1.0 SG I:CYS108 4.2 127.0 1.0 CA I:ALA110 4.3 122.0 1.0 N I:ALA110 4.3 121.5 1.0 CB I:LEU152 4.7 75.0 1.0 CD1 I:LEU152 4.7 77.3 1.0 CA I:CYS117 4.8 98.9 1.0 N I:CYS117 4.8 98.2 1.0 CD2 I:LEU94 4.8 112.4 1.0 N I:LEU112 4.8 97.8 1.0 C I:CYS154 4.9 102.0 1.0 CD2 I:LEU112 4.9 95.9 1.0

Iron binding site 4 out of 4 in the Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Structure of the Core Isc Complex Under Turnover Conditions (FDX2- Bound in Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ H:Fe201 b:123.3 occ:1.00 OD2 H:ASP71 2.0 72.5 1.0 NE2 H:HIS137 2.1 86.9 1.0 SG H:CYS95 2.3 62.5 1.0 SG E:CYS381 2.4 105.4 1.0 CG H:ASP71 2.9 67.8 1.0 CE1 H:HIS137 3.1 86.3 1.0 OD1 H:ASP71 3.1 65.9 1.0 CD2 H:HIS137 3.2 85.8 1.0 CB H:CYS95 3.5 47.7 1.0 SG H:CYS138 3.8 76.6 1.0 CB E:CYS381 4.0 99.8 1.0 SG H:CYS69 4.0 87.2 1.0 ND1 H:HIS137 4.2 87.6 1.0 CG H:HIS137 4.3 85.9 1.0 N H:CYS95 4.3 51.2 1.0 CB H:ASP71 4.3 64.8 1.0 CA H:CYS95 4.6 45.5 1.0 CB H:ALA98 4.7 44.1 1.0

R.Steinhilper, L.Boss, S.A.Freibert, V.Schulz, N.Krapoth, S.Kaltwasser, R.Lill, B.J.Murphy. Two-Stage Binding of Mitochondrial Ferredoxin-2 to the Core Iron-Sulfur Cluster Assembly Complex. Nat Commun V. 15 10559 2024.
ISSN: ESSN 2041-1723
PubMed: 39632806
DOI: 10.1038/S41467-024-54585-4