Iron in PDB 9g5e: Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F)

The structure of Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F) also contains other interesting chemical elements:

Magnesium	(Mg)	45 atoms
Zinc	(Zn)	1 atom
Potassium	(K)	1 atom

The binding sites of Iron atom in the Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F) (pdb code 9g5e). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F), PDB code: 9g5e:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F) within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe201 b:80.9 occ:1.00 FE1 P:FES201 0.0 80.9 1.0 S2 P:FES201 2.2 80.9 1.0 S1 P:FES201 2.2 80.9 1.0 SG E:CYS105 2.3 87.6 1.0 SG P:CYS68 2.3 60.2 1.0 O E:CYS105 2.6 87.6 1.0 FE2 P:FES201 2.7 80.9 1.0 CB P:CYS68 3.1 60.2 1.0 CB E:CYS105 3.1 87.6 1.0 C E:CYS105 3.4 87.6 1.0 N E:GLY107 3.7 95.6 1.0 CA E:GLY107 3.8 95.6 1.0 CA E:CYS105 3.9 87.6 1.0 O E:GLY107 4.2 95.6 1.0 CA P:CYS68 4.2 60.2 1.0 C E:GLY107 4.2 95.6 1.0 SG P:CYS65 4.2 64.3 1.0 CG P:LYS64 4.3 84.3 1.0 N P:CYS65 4.4 64.3 1.0 C E:GLU106 4.4 101.2 1.0 N E:GLU106 4.5 101.2 1.0 SG P:CYS100 4.5 56.1 1.0 CB P:LYS64 4.6 84.3 1.0 CA P:LYS64 4.7 84.3 1.0 CB P:CYS100 4.7 56.1 1.0 N E:CYS105 4.9 87.6 1.0 CE P:LYS64 4.9 84.3 1.0 CD P:LYS64 4.9 84.3 1.0

Iron binding site 2 out of 4 in the Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F) within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe201 b:80.9 occ:1.00 FE2 P:FES201 0.0 80.9 1.0 S1 P:FES201 2.2 80.9 1.0 S2 P:FES201 2.2 80.9 1.0 SG P:CYS100 2.3 56.1 1.0 SG P:CYS65 2.3 64.3 1.0 CB P:CYS100 2.6 56.1 1.0 FE1 P:FES201 2.7 80.9 1.0 CB P:CYS65 3.3 64.3 1.0 SG E:CYS105 3.4 87.6 1.0 CA P:CYS100 3.8 56.1 1.0 CG P:LYS103 3.8 50.3 1.0 CB P:CYS68 3.8 60.2 1.0 N P:CYS100 3.9 56.1 1.0 N P:CYS65 4.1 64.3 1.0 SG P:CYS68 4.2 60.2 1.0 CA P:CYS65 4.3 64.3 1.0 CB P:LYS103 4.4 50.3 1.0 CA P:CYS68 4.4 60.2 1.0 N P:CYS68 4.7 60.2 1.0 CB E:CYS105 4.7 87.6 1.0 C P:CYS100 4.7 56.1 1.0 O P:CYS65 4.9 64.3 1.0 CG1 E:ILE108 4.9 89.8 1.0 N P:LYS103 5.0 50.3 1.0 C P:CYS65 5.0 64.3 1.0

Iron binding site 3 out of 4 in the Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F) within 5.0Å range: probe atom residue distance (Å) B Occ T:Fe201 b:62.2 occ:1.00 FE1 T:FES201 0.0 62.2 1.0 S2 T:FES201 2.2 62.2 1.0 S1 T:FES201 2.2 62.2 1.0 SG T:CYS149 2.3 50.5 1.0 SG M:CYS26 2.3 39.5 1.0 FE2 T:FES201 2.7 62.2 1.0 CB T:CYS149 3.5 50.5 1.0 CB M:CYS26 3.6 39.5 1.0 N M:CYS26 4.0 39.5 1.0 CA T:CYS149 4.2 50.5 1.0 C M:GLY25 4.3 73.6 1.0 SG T:CYS141 4.3 45.0 1.0 CA M:CYS26 4.4 39.5 1.0 CD T:PRO150 4.5 44.9 1.0 SG T:CYS139 4.6 42.1 1.0 CA M:GLY25 4.6 73.6 1.0 CB T:CYS141 4.8 45.0 1.0 O M:GLY25 4.9 73.6 1.0 CB T:CYS139 4.9 42.1 1.0

Iron binding site 4 out of 4 in the Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Translation-Initiation State of Human Mitochondrial Ribosome Small Subunit (State F) within 5.0Å range: probe atom residue distance (Å) B Occ T:Fe201 b:62.2 occ:1.00 FE2 T:FES201 0.0 62.2 1.0 S2 T:FES201 2.2 62.2 1.0 S1 T:FES201 2.2 62.2 1.0 SG T:CYS141 2.3 45.0 1.0 SG T:CYS139 2.3 42.1 1.0 FE1 T:FES201 2.7 62.2 1.0 CB T:CYS141 2.7 45.0 1.0 CB T:CYS139 2.8 42.1 1.0 N T:CYS141 3.8 45.0 1.0 CA T:CYS141 3.9 45.0 1.0 CB T:CYS149 3.9 50.5 1.0 SG T:CYS149 4.0 50.5 1.0 CA T:CYS139 4.2 42.1 1.0 CA T:CYS149 4.5 50.5 1.0 C T:CYS139 4.6 42.1 1.0 C T:CYS141 4.8 45.0 1.0 N T:ILE140 4.8 42.0 1.0 N T:GLU142 4.8 45.4 1.0 SG M:CYS26 4.9 39.5 1.0 CA M:GLY25 4.9 73.6 1.0 N T:CYS149 5.0 50.5 1.0

M.Heinrichs, A.F.Finke, S.Aibara, H.S.Hillen, R.Richter-Dennerlein. Coupling of Ribosome Biogenesis and Translation Initiation in Human Mitochondria Nat Commun 2025.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-025-58827-X