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Iron in PDB 7a5y: Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Protein crystallography data
The structure of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg, PDB code: 7a5y
was solved by
E.R.Morris,
S.Kunzelmann,
S.J.Caswell,
A.Purkiss,
I.A.Taylor,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 153.15 / 2.29 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 80.193, 181.263, 286.331, 90, 90, 90 |
| R / Rfree (%) | 21 / 24 |
Other elements in 7a5y:
The structure of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg also contains other interesting chemical elements:
| Magnesium | (Mg) | 24 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
(pdb code 7a5y). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg, PDB code: 7a5y:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Iron where determined in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg, PDB code: 7a5y:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Iron binding site 1 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 1 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 2 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 2 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 3 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 3 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 4 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 4 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 5 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 5 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 6 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 6 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 7 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 7 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 7 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Iron binding site 8 out of 8 in 7a5y
Go back to
Iron Binding Sites List in 7a5y
Iron binding site 8 out
of 8 in the Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 8 of Crystal Structure of Tetrameric Human H215A-SAMHD1 (Residues 109-626) with Rp-Dgtp-Alphas (T8T) and Mg within 5.0Å range:
|
Reference:
E.R.Morris,
S.Kunzelmann,
S.J.Caswell,
A.G.Purkiss,
G.Kelly,
I.A.Taylor.
Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R P - and S P -Dntp Alpha S Diastereomers. Biochemistry 2021.
ISSN: ISSN 0006-2960
PubMed: 33988981
DOI: 10.1021/ACS.BIOCHEM.0C00944
Page generated: Wed Aug 6 19:05:57 2025
ISSN: ISSN 0006-2960
PubMed: 33988981
DOI: 10.1021/ACS.BIOCHEM.0C00944
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