Iron in PDB 1yci: Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine:
1.14.11.16;

The structure of Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine, PDB code: 1yci was solved by M.A.Mcdonough, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.45 / 2.70
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.853, 86.853, 150.519, 90.00, 90.00, 90.00
R / Rfree (%)	21 / 24.4

The binding sites of Iron atom in the Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine (pdb code 1yci). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine, PDB code: 1yci:

Iron binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with N-(Carboxycarbonyl)-D- Phenylalanine within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1350 b:47.5 occ:1.00 O A:HOH1045 2.0 42.0 1.0 OD2 A:ASP201 2.2 43.1 1.0 O2 A:NDF400 2.2 48.4 1.0 O2' A:NDF400 2.2 48.6 1.0 NE2 A:HIS199 2.3 38.7 1.0 NE2 A:HIS279 2.4 48.0 1.0 C1 A:NDF400 2.9 47.9 1.0 C2 A:NDF400 3.0 48.0 1.0 CE1 A:HIS199 3.1 38.6 1.0 CD2 A:HIS279 3.2 46.5 1.0 CG A:ASP201 3.2 41.8 1.0 CE1 A:HIS279 3.4 47.6 1.0 CD2 A:HIS199 3.4 38.6 1.0 OD1 A:ASP201 3.6 42.4 1.0 O A:HOH1074 4.1 35.6 1.0 O1 A:NDF400 4.1 50.0 1.0 N A:NDF400 4.3 47.1 1.0 ND1 A:HIS199 4.3 37.7 1.0 CZ2 A:TRP296 4.3 59.9 1.0 CG A:HIS279 4.4 45.6 1.0 ND1 A:HIS279 4.5 46.8 1.0 CG A:HIS199 4.5 37.9 1.0 CB A:ASP201 4.6 41.7 1.0 CE2 A:NDF400 5.0 49.9 1.0 CD2 A:NDF400 5.0 48.7 1.0

M.A.Mcdonough, L.A.Mcneill, M.Tilliet, C.A.Papamicael, Q.Y.Chen, B.Banerji, K.S.Hewitson, C.J.Schofield. Selective Inhibition of Factor Inhibiting Hypoxia-Inducible Factor J.Am.Chem.Soc. V. 127 7680 2005.
ISSN: ISSN 0002-7863
PubMed: 15913349
DOI: 10.1021/JA050841B