Atomistry » Iron » PDB 1zlq-2ai5 » 1zzu
Atomistry »
  Iron »
    PDB 1zlq-2ai5 »
      1zzu »

Iron in PDB 1zzu: Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound

Enzymatic activity of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound

All present enzymatic activity of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound:
1.14.13.39;

Protein crystallography data

The structure of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound, PDB code: 1zzu was solved by H.Li, M.L.Flinspach, J.Igarashi, J.Jamal, W.Yang, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.91 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 52.360, 111.130, 165.160, 90.00, 90.00, 90.00
R / Rfree (%) 20.2 / 22.8

Other elements in 1zzu:

The structure of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Iron Binding Sites:

The binding sites of Iron atom in the Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound (pdb code 1zzu). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound, PDB code: 1zzu:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1zzu

Go back to Iron Binding Sites List in 1zzu
Iron binding site 1 out of 2 in the Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe750

b:14.6
occ:1.00
FE A:HEM750 0.0 14.6 1.0
ND A:HEM750 2.0 17.2 1.0
NC A:HEM750 2.0 16.5 1.0
NB A:HEM750 2.0 17.0 1.0
NA A:HEM750 2.0 16.6 1.0
SG A:CYS415 2.3 15.4 1.0
C1D A:HEM750 3.1 16.9 1.0
C4D A:HEM750 3.1 16.6 1.0
C1C A:HEM750 3.1 17.2 1.0
C1B A:HEM750 3.1 17.3 1.0
C4C A:HEM750 3.1 16.9 1.0
C1A A:HEM750 3.1 16.6 1.0
C4B A:HEM750 3.1 17.3 1.0
C4A A:HEM750 3.1 16.6 1.0
CB A:CYS415 3.3 15.9 1.0
CHD A:HEM750 3.4 16.6 1.0
CHC A:HEM750 3.4 17.5 1.0
CHA A:HEM750 3.5 16.7 1.0
CHB A:HEM750 3.5 17.0 1.0
CA A:CYS415 4.1 15.0 1.0
C3D A:HEM750 4.3 17.7 1.0
C2D A:HEM750 4.3 17.3 1.0
NH1 A:DP1790 4.3 33.0 1.0
C2B A:HEM750 4.3 17.8 1.0
C3C A:HEM750 4.3 17.0 1.0
C2C A:HEM750 4.3 17.3 1.0
C3B A:HEM750 4.3 17.9 1.0
C2A A:HEM750 4.3 16.2 1.0
C3A A:HEM750 4.4 16.8 1.0
NE1 A:TRP409 4.4 15.5 1.0
NO A:DP1790 4.5 33.0 1.0
CZ A:DP1790 4.8 34.4 1.0
O2 A:DP1790 4.8 33.0 1.0
C A:CYS415 4.8 15.3 1.0
N A:GLY417 4.9 15.9 1.0
O3 A:DP1790 4.9 31.8 1.0
N A:VAL416 5.0 15.0 1.0

Iron binding site 2 out of 2 in 1zzu

Go back to Iron Binding Sites List in 1zzu
Iron binding site 2 out of 2 in the Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe750

b:13.2
occ:1.00
FE B:HEM750 0.0 13.2 1.0
NC B:HEM750 2.0 14.6 1.0
NA B:HEM750 2.0 14.5 1.0
ND B:HEM750 2.0 14.2 1.0
NB B:HEM750 2.0 14.8 1.0
SG B:CYS415 2.3 12.9 1.0
C4C B:HEM750 3.1 14.9 1.0
C1D B:HEM750 3.1 14.5 1.0
C1C B:HEM750 3.1 15.1 1.0
C4B B:HEM750 3.1 15.8 1.0
C4D B:HEM750 3.1 14.4 1.0
C1A B:HEM750 3.1 14.4 1.0
C1B B:HEM750 3.1 15.8 1.0
C4A B:HEM750 3.1 15.1 1.0
CB B:CYS415 3.4 12.5 1.0
CHD B:HEM750 3.4 14.8 1.0
CHC B:HEM750 3.4 14.9 1.0
CHA B:HEM750 3.5 14.2 1.0
CHB B:HEM750 3.5 15.2 1.0
CA B:CYS415 4.1 12.1 1.0
C2D B:HEM750 4.3 14.4 1.0
C3C B:HEM750 4.3 15.2 1.0
C3D B:HEM750 4.3 15.3 1.0
C2C B:HEM750 4.3 14.8 1.0
C3B B:HEM750 4.3 16.9 1.0
C2A B:HEM750 4.3 14.9 1.0
C2B B:HEM750 4.3 16.3 1.0
C3A B:HEM750 4.3 14.8 1.0
NE1 B:TRP409 4.4 11.0 1.0
NH1 B:DP1791 4.4 33.8 1.0
NO B:DP1791 4.5 33.6 1.0
O2 B:DP1791 4.7 34.8 1.0
CZ B:DP1791 4.8 34.8 1.0
N B:GLY417 4.8 13.1 1.0
C B:CYS415 4.9 12.5 1.0
O3 B:DP1791 5.0 32.4 1.0
N B:VAL416 5.0 11.9 1.0
NH2 B:DP1791 5.0 33.5 1.0

Reference:

H.Li, M.L.Flinspach, J.Igarashi, J.Jamal, W.Yang, E.A.Litzinger, H.Huang, E.P.Erdal, R.B.Silverman, T.L.Poulos. Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases. Biochemistry V. 44 15222 2005.
ISSN: ISSN 0006-2960
PubMed: 16285725
DOI: 10.1021/BI0513610
Page generated: Sat Aug 3 18:47:31 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy